Search Results - "Wood, Delaney"
-
1
High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia
Published in Nature communications (17-01-2024)“…Unbiased phenotypic screens in patient-relevant disease models offer the potential to detect therapeutic targets for rare diseases. In this study, we developed…”
Get full text
Journal Article -
2
The role of TSC1 and TSC2 proteins in neuronal axons
Published in Molecular psychiatry (01-04-2024)“…Tuberous Sclerosis Complex 1 and 2 proteins, TSC1 and TSC2 respectively, participate in a multiprotein complex with a crucial role for the proper development…”
Get full text
Journal Article -
3
A Hybrid 2D-to-3D in vitro Differentiation Platform Improves Outcomes of Cerebral Cortical Organoid Generation in hiPSCs
Published in Current protocols (01-10-2024)“…Three-dimensional (3D) cerebral cortical organoids are popular in vitro cellular model systems widely used to study human brain development and disease,…”
Get more information
Journal Article -
4
A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells
Published in Current protocols (01-01-2023)“…Disordered cellular development, abnormal neuroanatomical formations, and dysfunction of neuronal circuitry are among the pathological manifestations of…”
Get more information
Journal Article