Search Results - "Wood, Angela M."

Extending the MR‐Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy by Rees, Jessica M. B., Wood, Angela M., Burgess, Stephen

“…Methods have been developed for Mendelian randomization that can obtain consistent causal estimates while relaxing the instrumental variable assumptions. These…”
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Multiple imputation using chained equations: Issues and guidance for practice by White, Ian R., Royston, Patrick, Wood, Angela M.

“…Multiple imputation by chained equations is a flexible and practical approach to handling missing data. We describe the principles of the method and show how…”
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Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates by Rees, Jessica M B, Wood, Angela M, Dudbridge, Frank, Burgess, Stephen

“…Methods have been developed for Mendelian randomization that can obtain consistent causal estimates under weaker assumptions than the standard instrumental…”
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Mendelian Randomization Study of ACLY and Cardiovascular Disease by Ference, Brian A, Ray, Kausik K, Catapano, Alberico L, Ference, Thatcher B, Burgess, Stephen, Neff, David R, Oliver-Williams, Clare, Wood, Angela M, Butterworth, Adam S, Di Angelantonio, Emanuele, Danesh, John, Kastelein, John J.P, Nicholls, Stephen J

“…The effects on lipid profiles of pharmacologic inhibition of ATP citrate lyase, an enzyme in the cholesterol–biosynthesis pathway upstream of HMGCR (the target…”
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Correcting for Optimistic Prediction in Small Data Sets by SMITH, Gordon C. S, SEAMAN, Shaun R, WOOD, Angela M, ROYSTON, Patrick, WHITE, Ian R

“…The C statistic is a commonly reported measure of screening test performance. Optimistic estimation of the C statistic is a frequent problem because of…”
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Association Between Depressive Symptoms and Incident Cardiovascular Diseases by Harshfield, Eric L, Pennells, Lisa, Schwartz, Joseph E, Willeit, Peter, Kaptoge, Stephen, Bell, Steven, Shaffer, Jonathan A, Bolton, Thomas, Spackman, Sarah, Wassertheil-Smoller, Sylvia, Kee, Frank, Amouyel, Philippe, Shea, Steven J, Kuller, Lewis H, Kauhanen, Jussi, van Zutphen, E. M, Blazer, Dan G, Krumholz, Harlan, Nietert, Paul J, Kromhout, Daan, Laughlin, Gail, Berkman, Lisa, Wallace, Robert B, Simons, Leon A, Dennison, Elaine M, Barr, Elizabeth L. M, Meyer, Haakon E, Wood, Angela M, Danesh, John, Di Angelantonio, Emanuele, Davidson, Karina W

“…IMPORTANCE: It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs). OBJECTIVE: To…”
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ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci by Stacey, David, Fauman, Eric B, Ziemek, Daniel, Sun, Benjamin B, Harshfield, Eric L, Wood, Angela M, Butterworth, Adam S, Suhre, Karsten, Paul, Dirk S

“…Abstract Quantitative trait locus (QTL) mapping of molecular phenotypes such as metabolites, lipids and proteins through genome-wide association studies…”
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A cross-platform approach identifies genetic regulators of human metabolism and health by Lotta, Luca A., Pietzner, Maik, Stewart, Isobel D., Wittemans, Laura B. L., Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma K., Oliver-Williams, Clare, Auyeung, Victoria P. W., Luan, Jian’an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory A., Scott, Robert A., Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita G., Khaw, Kay-Tee, Griffin, Julian L., Wood, Angela M., Kastenmüller, Gabi, Danesh, John, Butterworth, Adam S., Gribble, Fiona M., Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas J., Langenberg, Claudia

“…In cross-platform analyses of 174 metabolites, we identify 499 associations ( P  < 4.9 × 10 −10 ) characterized by pleiotropy, allelic heterogeneity, large and…”
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Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis by Fermont, Jilles M, Masconi, Katya L, Jensen, Magnus T, Ferrari, Renata, Di Lorenzo, Valéria A P, Marott, Jacob M, Schuetz, Philipp, Watz, Henrik, Waschki, Benjamin, Müllerova, Hana, Polkey, Michael I, Wilkinson, Ian B, Wood, Angela M

“…Conventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying…”
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Assessing the causal association of glycine with risk of cardio-metabolic diseases by Wittemans, Laura B. L., Lotta, Luca A., Oliver-Williams, Clare, Stewart, Isobel D., Surendran, Praveen, Karthikeyan, Savita, Day, Felix R., Koulman, Albert, Imamura, Fumiaki, Zeng, Lingyao, Erdmann, Jeanette, Schunkert, Heribert, Khaw, Kay-Tee, Griffin, Julian L., Forouhi, Nita G., Scott, Robert A., Wood, Angela M., Burgess, Stephen, Howson, Joanna M. M., Danesh, John, Wareham, Nicholas J., Butterworth, Adam S., Langenberg, Claudia

“…Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains…”
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Effect of interpregnancy weight change on perinatal outcomes: systematic review and meta-analysis by Teulings, Noor E W D, Masconi, Katya L, Ozanne, Susan E, Aiken, Catherine E, Wood, Angela M

“…Although obesity is a well-known risk factor for adverse pregnancy outcomes, evidence is sparse about the effects of interpregnancy weight change on the risk…”
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4-Hydroxyglutamate is a novel predictor of pre-eclampsia by Sovio, Ulla, McBride, Nancy, Wood, Angela M, Masconi, Katya L, Cook, Emma, Gaccioli, Francesca, Charnock-Jones, D Stephen, Lawlor, Debbie A, Smith, Gordon C S

“…Abstract Background Pre-term pre-eclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. A multi-centre randomized–controlled…”
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Prioritising cardiovascular disease risk assessment to high risk individuals based on primary care records by Chung, Ryan, Xu, Zhe, Arnold, Matthew, Stevens, David, Keogh, Ruth, Barrett, Jessica, Harrison, Hannah, Pennells, Lisa, Kim, Lois G, DiAngelantonio, Emanuele, Paige, Ellie, Usher-Smith, Juliet A, Wood, Angela M

“…To provide quantitative evidence for systematically prioritising individuals for full formal cardiovascular disease (CVD) risk assessment using primary care…”
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Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England by Ip, Samantha, North, Teri-Louise, Torabi, Fatemeh, Li, Yangfan, Abbasizanjani, Hoda, Akbari, Ashley, Horne, Elsie, Denholm, Rachel, Keene, Spencer, Denaxas, Spiros, Banerjee, Amitava, Khunti, Kamlesh, Sudlow, Cathie, Whiteley, William N., Sterne, Jonathan A. C., Wood, Angela M., Walker, Venexia

“…The first dose of COVID-19 vaccines led to an overall reduction in cardiovascular events, and in rare cases, cardiovascular complications. There is less…”
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A review of published analyses of case-cohort studies and recommendations for future reporting by Sharp, Stephen J, Poulaliou, Manon, Thompson, Simon G, White, Ian R, Wood, Angela M

“…The case-cohort study design combines the advantages of a cohort study with the efficiency of a nested case-control study. However, unlike more standard…”
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Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease by Fermont, Jilles M, Mohan, Divya, Fisk, Marie, Bolton, Charlotte E, Macnee, William, Cockcroft, John R, McEniery, Carmel, Fuld, Jonathan, Cheriyan, Joseph, Tal-Singer, Ruth, Müllerova, Hana, Wood, Angela M, Wilkinson, Ian B, Polkey, Michael I

“…Abstract Rationale chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and common in older adults. The BODE Index is the most…”
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Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study by Cezard, Genevieve I., Denholm, Rachel E., Knight, Rochelle, Wei, Yinghui, Teece, Lucy, Toms, Renin, Forbes, Harriet J., Walker, Alex J., Fisher, Louis, Massey, Jon, Hopcroft, Lisa E. M., Horne, Elsie M. F., Taylor, Kurt, Palmer, Tom, Arab, Marwa Al, Cuitun Coronado, Jose Ignacio, Ip, Samantha H. Y., Davy, Simon, Dillingham, Iain, Bacon, Sebastian, Mehrkar, Amir, Morton, Caroline E., Greaves, Felix, Hyams, Catherine, Davey Smith, George, Macleod, John, Chaturvedi, Nishi, Goldacre, Ben, Whiteley, William N., Wood, Angela M., Sterne, Jonathan A. C., Walker, Venexia

“…Infection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased…”
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Imputation methods for missing outcome data in meta-analysis of clinical trials by Higgins, Julian PT, White, Ian R, Wood, Angela M

“…Background: Missing outcome data from randomized trials lead to greater uncertainty and possible bias in estimating the effect of an experimental treatment. An…”
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Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci by Harshfield, Eric L, Fauman, Eric B, Stacey, David, Paul, Dirk S, Ziemek, Daniel, Ong, Rachel M Y, Danesh, John, Butterworth, Adam S, Rasheed, Asif, Sattar, Taniya, Zameer-Ul-Asar, Saleem, Imran, Hina, Zoubia, Ishtiaq, Unzila, Qamar, Nadeem, Mallick, Nadeem Hayat, Yaqub, Zia, Saghir, Tahir, Rizvi, Syed Nadeem Hasan, Memon, Anis, Ishaq, Mohammad, Rasheed, Syed Zahed, Memon, Fazal-Ur-Rehman, Jalal, Anjum, Abbas, Shahid, Frossard, Philippe, Saleheen, Danish, Wood, Angela M, Griffin, Julian L, Koulman, Albert

“…Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic…”
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Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study by Fermont, Jilles M, Bolton, Charlotte E, Fisk, Marie, Mohan, Divya, Macnee, William, Cockcroft, John R, McEniery, Carmel, Fuld, Jonathan, Cheriyan, Joseph, Tal-Singer, Ruth, Wilkinson, Ian B, Wood, Angela M, Polkey, Michael I, Müllerova, Hana

“…In chronic obstructive pulmonary disease (COPD), acute exacerbation of COPD requiring hospital admission is associated with mortality and healthcare costs. The…”
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