Search Results - "Woo, Marcel S"

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 by Krasemann, Susanne, Haferkamp, Undine, Pfefferle, Susanne, Woo, Marcel S., Heinrich, Fabian, Schweizer, Michaela, Appelt-Menzel, Antje, Cubukova, Alevtina, Barenberg, Janica, Leu, Jennifer, Hartmann, Kristin, Thies, Edda, Littau, Jessica Lisa, Sepulveda-Falla, Diego, Zhang, Liang, Ton, Kathy, Liang, Yan, Matschke, Jakob, Ricklefs, Franz, Sauvigny, Thomas, Sperhake, Jan, Fitzek, Antonia, Gerhartl, Anna, Brachner, Andreas, Geiger, Nina, König, Eva-Maria, Bodem, Jochen, Franzenburg, Sören, Franke, Andre, Moese, Stefan, Müller, Franz-Josef, Geisslinger, Gerd, Claussen, Carsten, Kannt, Aimo, Zaliani, Andrea, Gribbon, Philip, Ondruschka, Benjamin, Neuhaus, Winfried, Friese, Manuel A., Glatzel, Markus, Pless, Ole

“…Neurological complications are common in COVID-19. Although SARS-CoV-2 has been detected in patients’ brain tissues, its entry routes and resulting…”
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Atraumatic spinal needle indicates correct CSF opening pressure by Woo, Marcel S., Kessner, Simon S., Schlemm, Eckhard, Gerloff, Christian

“…The accurate assessment of cerebrospinal fluid opening pressure during spinal puncture provides important medical information in diagnosis, prognosis and…”
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Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis by Walkenhorst, Mark, Sonner, Jana K., Meurs, Nina, Engler, Jan Broder, Bauer, Simone, Winschel, Ingo, Woo, Marcel S., Raich, Lukas, Winkler, Iris, Vieira, Vanessa, Unger, Lisa, Salinas, Gabriela, Lantz, Olivier, Friese, Manuel A., Willing, Anne

“…Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin…”
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Voltage-Gated Proton Channel Hv1 Controls TLR9 Activation in Plasmacytoid Dendritic Cells by Montes-Cobos, Elena, Huscher, Britta, Engler, Jan Broder, Woo, Marcel S, Binkle, Lars, Bauer, Simone, Kursawe, Nina, Moles, Michael, Friese, Manuel A, Ufer, Friederike

“…The voltage-gated proton channel Hv1 regulates proton fluxes across membranes, thereby influencing pH-dependent processes. Plasmacytoid dendritic cells (pDCs)…”
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Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer's disease pathology by Therriault, Joseph, Woo, Marcel S, Salvadó, Gemma, Gobom, Johan, Karikari, Thomas K, Janelidze, Shorena, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Ashton, Nicholas J, Benedet, Andréa Lessa, Montoliu-Gaya, Laia, Macedo, Arthur C, Lussier, Firoza Z, Stevenson, Jenna, Vitali, Paolo, Friese, Manuel A, Massarweh, Gassan, Soucy, Jean-Paul, Pascoal, Tharick A, Stomrud, Erik, Palmqvist, Sebastian, Mattsson-Carlgren, Niklas, Gauthier, Serge, Zetterberg, Henrik, Hansson, Oskar, Blennow, Kaj, Rosa-Neto, Pedro

“…Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF),…”
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Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis by Winschel, Ingo, Willing, Anne, Engler, Jan Broder, Walkenhorst, Mark, Meurs, Nina, Binkle-Ladisch, Lars, Woo, Marcel S, Pfeffer, Lena Kristina, Sonner, Jana K, Borgmeyer, Uwe, Hagen, Sven Hendrik, Grünhagel, Benjamin, Claussen, Janna M, Altfeld, Marcus, Friese, Manuel A

“…Differences in immune responses between women and men are leading to a strong sex bias in the incidence of autoimmune diseases that predominantly affect women,…”
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Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study by Woo, Marcel S, Brehm, Thomas Theo, Fischer, Marlene, Heyer, Andreas, Wichmann, Dominic, Jordan, Sabine, Nörz, Dominik, Lütgehetmann, Marc, Addo, Marylyn M, Lohse, Ansgar W, Schmiedel, Stefan, Kluge, Stefan, Schulze Zur Wiesch, Julian

“…data suggest the monoclonal antibody sotrovimab may have lost inhibitory capability against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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The relation of synaptic biomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer's disease by Wang, Yi-Ting, Ashton, Nicholas J, Servaes, Stijn, Nilsson, Johanna, Woo, Marcel S, Pascoal, Tharick A, Tissot, Cécile, Rahmouni, Nesrine, Therriault, Joseph, Lussier, Firoza, Chamoun, Mira, Gauthier, Serge, Brinkmalm, Ann, Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro, Benedet, Andréa L

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Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 – A retrospective single-center cohort study by Brehm, Thomas Theo, Heyer, Andreas, Woo, Marcel S., Fischer, Marlene, van der Meirschen, Marc, Wichmann, Dominic, Jarczak, Dominik, Roedl, Kevin, Schmiedel, Stefan, Addo, Marylyn M., Lütgehetmann, Marc, Christner, Martin, Huber, Samuel, Lohse, Ansgar W., Kluge, Stefan, Schulze zur Wiesch, Julian

“…Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, the roll-out of vaccines and therapeutic agents, as well as the emergence of novel…”
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The neuropathobiology of multiple sclerosis by Woo, Marcel S., Engler, Jan Broder, Friese, Manuel A.

“…Chronic low-grade inflammation and neuronal deregulation are two components of a smoldering disease activity that drives the progression of disability in…”
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Multi-dimensional and longitudinal systems profiling reveals predictive pattern of severe COVID-19 by Woo, Marcel S., Haag, Friedrich, Nierhaus, Axel, Jarczak, Dominik, Roedl, Kevin, Mayer, Christina, Brehm, Thomas T., van der Meirschen, Marc, Hennigs, Annette, Christopeit, Maximilian, Fiedler, Walter, Karagiannis, Panagiotis, Burdelski, Christoph, Schultze, Alexander, Huber, Samuel, Addo, Marylyn M., Schmiedel, Stefan, Friese, Manuel A., Kluge, Stefan, Schulze zur Wiesch, Julian

“…COVID-19 is a respiratory tract infection that can affect multiple organ systems. Predicting the severity and clinical outcome of individual patients is a…”
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Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons by Hermann, Julia, Bender, Melanie, Schumacher, Dagmar, Woo, Marcel S., Shaposhnykov, Artem, Rosenkranz, Sina C., Kuryshev, Vladimir, Meier, Chris, Guse, Andreas H., Friese, Manuel A., Freichel, Marc, Tsvilovskyy, Volodymyr

“…Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of…”
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Frequent neurocognitive deficits after recovery from mild COVID-19 by Woo, Marcel S, Malsy, Jakob, Pöttgen, Jana, Seddiq Zai, Susan, Ufer, Friederike, Hadjilaou, Alexandros, Schmiedel, Stefan, Addo, Marylyn M, Gerloff, Christian, Heesen, Christoph, Schulze Zur Wiesch, Julian, Friese, Manuel A

“…Abstract Neuropsychiatric complications associated with coronavirus disease 2019 caused by the Coronavirus SARS-CoV-2 (COVID-19) are increasingly appreciated…”
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Vagus nerve inflammation contributes to dysautonomia in COVID-19 by Woo, Marcel S., Shafiq, Mohsin, Fitzek, Antonia, Dottermusch, Matthias, Altmeppen, Hermann, Mohammadi, Behnam, Mayer, Christina, Bal, Lukas C., Raich, Lukas, Matschke, Jakob, Krasemann, Susanne, Pfefferle, Susanne, Brehm, Thomas Theo, Lütgehetmann, Marc, Schädler, Julia, Addo, Marylyn M., Schulze zur Wiesch, Julian, Ondruschka, Benjamin, Friese, Manuel A., Glatzel, Markus

“…Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom burden after recovery from COVID-19 (long COVID), yet the underlying causes…”
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Astrocytic uptake of posttranslationally modified amyloid‐β leads to endolysosomal system disruption and induction of pro‐inflammatory signaling by Wirth, Sarah, Schlößer, Annika, Beiersdorfer, Antonia, Schweizer, Michaela, Woo, Marcel S., Friese, Manuel A., Lohr, Christian, Grochowska, Katarzyna M.

“…The disruption of astrocytic catabolic processes contributes to the impairment of amyloid‐β (Aβ) clearance, neuroinflammatory signaling, and the loss of…”
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Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation by Woo, Marcel S, Ufer, Friederike, Rothammer, Nicola, Di Liberto, Giovanni, Binkle, Lars, Haferkamp, Undine, Sonner, Jana K, Engler, Jan Broder, Hornig, Sönke, Bauer, Simone, Wagner, Ingrid, Egervari, Kristof, Raber, Jacob, Duvoisin, Robert M, Pless, Ole, Merkler, Doron, Friese, Manuel A

“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with continuous neuronal loss. Treatment of clinical progression…”
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis by Woo, Marcel S, Mayer, Christina, Binkle-Ladisch, Lars, Sonner, Jana K, Rosenkranz, Sina C, Shaposhnykov, Artem, Rothammer, Nicola, Tsvilovskyy, Volodymyr, Lorenz, Svenja M, Raich, Lukas, Bal, Lukas C, Vieira, Vanessa, Wagner, Ingrid, Bauer, Simone, Glatzel, Markus, Conrad, Marcus, Merkler, Doron, Freichel, Marc, Friese, Manuel A

“…Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet the underlying mechanisms remain unclear. By dissecting the…”
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Bassoon proteinopathy drives neurodegeneration in multiple sclerosis by Schattling, Benjamin, Engler, Jan Broder, Volkmann, Constantin, Rothammer, Nicola, Woo, Marcel S., Petersen, Meike, Winkler, Iris, Kaufmann, Max, Rosenkranz, Sina C., Fejtova, Anna, Thomas, Ulrich, Bose, Aparajita, Bauer, Simone, Träger, Simone, Miller, Katharine K., Brück, Wolfgang, Duncan, Kent E., Salinas, Gabriela, Soba, Peter, Gundelfinger, Eckart D., Merkler, Doron, Friese, Manuel A.

“…Multiple sclerosis (MS) is characterized by inflammatory insults that drive neuroaxonal injury. However, knowledge about neuron-intrinsic responses to…”
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The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis by Woo, Marcel S, Bal, Lukas C, Winschel, Ingo, Manca, Elias, Walkenhorst, Mark, Sevgili, Bachar, Sonner, Jana K, Di Liberto, Giovanni, Mayer, Christina, Binkle-Ladisch, Lars, Rothammer, Nicola, Unger, Lisa, Raich, Lukas, Hadjilaou, Alexandros, Noli, Barbara, Manai, Antonio L, Vieira, Vanessa, Meurs, Nina, Wagner, Ingrid, Pless, Ole, Cocco, Cristina, Stephens, Samuel B, Glatzel, Markus, Merkler, Doron, Friese, Manuel A

“…A disturbed balance between excitation and inhibition (E/I balance) is increasingly recognized as a key driver of neurodegeneration in multiple sclerosis (MS),…”
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Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease by Grochowska, Katarzyna M, Gomes, Guilherme M, Raman, Rajeev, Kaushik, Rahul, Sosulina, Liudmila, Kaneko, Hiroshi, Oelschlegel, Anja M, Yuanxiang, PingAn, Reyes‐Resina, Irene, Bayraktar, Gonca, Samer, Sebastian, Spilker, Christina, Woo, Marcel S, Morawski, Markus, Goldschmidt, Jürgen, Friese, Manuel A, Rossner, Steffen, Navarro, Gemma, Remy, Stefan, Reissner, Carsten, Karpova, Anna, Kreutz, Michael R

“…Synaptic dysfunction caused by soluble β‐amyloid peptide (Aβ) is a hallmark of early‐stage Alzheimer's disease (AD), and is tightly linked to cognitive…”
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