Search Results - "Woo, Andrew J."

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs by Kim, Jonghwan, Woo, Andrew J., Chu, Jianlin, Snow, Jonathan W., Fujiwara, Yuko, Kim, Chul Geun, Cantor, Alan B., Orkin, Stuart H.

“…c-Myc (Myc) is an important transcriptional regulator in embryonic stem (ES) cells, somatic cell reprogramming, and cancer. Here, we identify a Myc-centered…”
Get full text

Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors by Yu, Ming, Mazor, Tali, Huang, Hui, Huang, Hsuan-Ting, Kathrein, Katie L., Woo, Andrew J., Chouinard, Candace R., Labadorf, Adam, Akie, Thomas E., Moran, Tyler B., Xie, Huafeng, Zacharek, Sima, Taniuchi, Ichiro, Roeder, Robert G., Kim, Carla F., Zon, Leonard I., Fraenkel, Ernest, Cantor, Alan B.

“…Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian…”
Get full text

The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer by Beveridge, Dianne J., Richardson, Kirsty L., Epis, Michael R., Brown, Rikki A. M., Stuart, Lisa M., Woo, Andrew J., Leedman, Peter J.

“…RNA-based therapeutics are emerging as innovative options for cancer treatment, with microRNAs being attractive targets for therapy development. We previously…”
Get full text

miR-101 suppresses the development of MLL -rearranged acute myeloid leukemia by Gonzales-Aloy, Estrella, Connerty, Patrick, Salik, Basit, Liu, Bing, Woo, Andrew J, Haber, Michelle, Norris, Murray D, Wang, Jianlong, Wang, Jenny Y

Get full text

A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer by Kim, Mijeong, Singh, Manjot, Lee, Bum-Kyu, Hibbs, Moira, Richardson, Kirsty, Ellies, Lesley, Wintle, Larissa, Stuart, Lisa M., Wang, Jenny Y., Voon, Dominic C., Blancafort, Pilar, Wang, Jianlong, Kim, Jonghwan, Leedman, Peter J., Woo, Andrew J.

“…The MYC proto-oncogene ( MYC ) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in…”
Get full text

Differentiation-Dependent Interactions between RUNX-1 and FLI-1 during Megakaryocyte Development by Huang, Hui, Yu, Ming, Akie, Thomas E., Moran, Tyler B., Woo, Andrew J., Tu, Nathan, Waldon, Zachary, Lin, Yin Yin, Steen, Hanno, Cantor, Alan B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans by McGrath, Francesca M, Francis, Abbie, Fatovich, Daniel M, Macdonald, Stephen PJ, Arendts, Glenn, Woo, Andrew J, Bosio, Erika

“…Objective Mechanisms underlying the anaphylactic reaction in humans are not fully understood. Here, we aimed at improving our understanding of anaphylaxis by…”
Get full text

Identification of ZBP-89 as a Novel GATA-1-Associated Transcription Factor Involved in Megakaryocytic and Erythroid Development by Woo, Andrew J., Moran, Tyler B., Schindler, Yocheved L., Choe, Seong-Kyu, Langer, Nathaniel B., Sullivan, Matthew R., Fujiwara, Yuko, Paw, Barry H., Cantor, Alan B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development by Woo, Andrew J., Patry, Chelsea-Ann A., Ghamari, Alireza, Pregernig, Gabriela, Yuan, Daniel, Zheng, Kangni, Piers, Taylor, Hibbs, Moira, Li, Ji, Fidalgo, Miguel, Wang, Jenny Y., Lee, Joo-Hyeon, Leedman, Peter J., Wang, Jianlong, Fraenkel, Ernest, Cantor, Alan B.

“…Erythroid maturation requires the concerted action of a core set of transcription factors. We previously identified the Krüppel-type zinc finger transcription…”
Get full text

Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers by Wang, Edina, Sorolla, Anabel, Cunningham, Paula T., Bogdawa, Heique M., Beck, Samuel, Golden, Emily, Dewhurst, Robert E., Florez, Laura, Cruickshank, Mark N., Hoffmann, Katrin, Hopkins, Richard M., Kim, Jonghwan, Woo, Andrew J., Watt, Paul M., Blancafort, Pilar

“…Overexpression of MYC oncogene is highly prevalent in many malignancies such as aggressive triple-negative breast cancers (TNBCs) and it is associated with…”
Get full text

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis by Lynch, Jennifer R., Salik, Basit, Connerty, Patrick, Vick, Binje, Leung, Halina, Pijning, Aster, Jeremias, Irmela, Spiekermann, Karsten, Trahair, Toby, Liu, Tao, Haber, Michelle, Norris, Murray D., Woo, Andrew J., Hogg, Philip, Wang, Jianlong, Wang, Jenny Y.

“…Abnormal metabolism is a fundamental hallmark of cancer and represents a therapeutic opportunity, yet its regulation by oncogenes remains poorly understood…”
Get full text

CpG island-mediated global gene regulatory modes in mouse embryonic stem cells by Beck, Samuel, Lee, Bum-Kyu, Rhee, Catherine, Song, Jawon, Woo, Andrew J., Kim, Jonghwan

“…Both transcriptional and epigenetic regulations are fundamental for the control of eukaryotic gene expression. Here we perform a compendium analysis of >200…”
Get full text

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer by Golden, Emily, Rashwan, Rabab, Woodward, Eleanor A., Sgro, Agustin, Wang, Edina, Sorolla, Anabel, Waryah, Charlene, Tie, Wan Jun, Cuyàs, Elisabet, Ratajska, Magdalena, Kardaś, Iwona, Kozlowski, Piotr, Johnstone, Elizabeth K. M., See, Heng B., Duffy, Ciara, Parry, Jeremy, Lagerborg, Kim A., Czapiewski, Piotr, Menendez, Javier A., Gorczyński, Adam, Wasag, Bartosz, Pfleger, Kevin D. G., Curtis, Christina, Lee, Bum-Kyu, Kim, Jonghwan, Cursons, Joseph, Pavlos, Nathan J., Biernat, Wojciech, Jain, Mohit, Woo, Andrew J., Redfern, Andrew, Blancafort, Pilar

“…Adipogenesis associated Mth938 domain containing (AAMDC) represents an uncharacterized oncogene amplified in aggressive estrogen receptor-positive breast…”
Get full text

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation by Huang, Hui, Woo, Andrew J, Waldon, Zachary, Schindler, Yocheved, Moran, Tyler B, Zhu, Helen H, Feng, Gen-Sheng, Steen, Hanno, Cantor, Alan B

“…Hematopoietic development occurs in complex microenvironments and is influenced by key signaling events. Yet how these pathways communicate with master…”
Get full text

Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation by Woo, Andrew J, Wieland, Karen, Huang, Hui, Akie, Thomas E, Piers, Taylor, Kim, Jonghwan, Cantor, Alan B

“…About 10% of Down syndrome (DS) infants are born with a transient myeloproliferative disorder (DS-TMD) that spontaneously resolves within the first few months…”
Get full text

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia by Salik, Basit, Yi, Hangyu, Hassan, Nunki, Santiappillai, Nancy, Vick, Binje, Connerty, Patrick, Duly, Alastair, Trahair, Toby, Woo, Andrew J., Beck, Dominik, Liu, Tao, Spiekermann, Karsten, Jeremias, Irmela, Wang, Jianlong, Kavallaris, Maria, Haber, Michelle, Norris, Murray D., Liebermann, Dan A., D'Andrea, Richard J., Murriel, Christopher, Wang, Jenny Y.

“…Signals driving aberrant self-renewal in the heterogeneous leukemia stem cell (LSC) pool determine aggressiveness of acute myeloid leukemia (AML). We report…”
Get full text

A Proteomics Approach for the Identification of DNA Binding Activities Observed in the Electrophoretic Mobility Shift Assay by Woo, Andrew J, Dods, James S, Susanto, Evelyn, Ulgiati, Daniela, Abraham, Lawrence J

“…Transcription factors lie at the center of gene regulation, and their identification is crucial to the understanding of transcription and gene expression…”
Get full text

Role of ZBP-89 in human globin gene regulation and erythroid differentiation by Woo, Andrew J., Kim, Jonghwan, Xu, Jian, Huang, Hui, Cantor, Alan B.

“…The molecular mechanisms underlying erythroid-specific gene regulation remain incompletely understood. Closely spaced binding sites for GATA, NF-E2/maf, and…”
Get full text

Abstract 2379: microRNA-7 replacement therapy: a promising approach for hepatocellular carcinoma by Beveridge, Dianne J., Kabir, Tasnuva, Woo, Andrew J., Richardson, Kirsty L., Stuart, Lisa M., Leedman, Peter J.

“…Abstract Hepatocellular carcinoma (HCC) is increasing in incidence, has a very poor prognosis and presents massive global unmet clinical need. Current…”
Get full text

Essential Role of the Transcription Factor ZBP-89 in Lymphopoiesis by Woo, Andrew J., Huang, Hui, Piers, Taylor, Cantor, Alan B

“…Abstract 277 We previously identified the Krüppel-type zinc finger transcription factor ZBP-89 (also called zfp148) as a novel GATA1 associated protein in…”
Get full text