Search Results - "Wonodi, Ikwunga"

Nicotine Effect on Prepulse Inhibition and Prepulse Facilitation in Schizophrenia Patients by ELLIOT HONG, L, WONODI, Ikwunga, LEWIS, Jada, THAKER, Gunvant K

“…Acoustic prepulse inhibition (PPI) is considered an important biomarker in animal studies of psychosis and a number of psychiatric conditions. Nicotine has…”
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Evidence of Missense Mutations on the Neuregulin 1 Gene Affecting Function of Prepulse Inhibition by Hong, L. Elliot, Wonodi, Ikwunga, Stine, O. Colin, Mitchell, Braxton D, Thaker, Gunvant K

“…Background Neuregulin 1 ( NRG1 ) is one of the leading candidate genes in schizophrenia. Rodents with NRG1 knock-out showed significantly impaired prepulse…”
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Specific motion processing pathway deficit during eye tracking in schizophrenia: A performance-matched functional magnetic resonance imaging study by Hong, L. Elliot, Tagamets, Malle, Avila, Matthew, Wonodi, Ikwunga, Holcomb, Henry, Thaker, Gunvant K.

“…The neural mechanisms underlying smooth pursuit eye movement (SPEM) abnormalities in schizophrenia are not well understood. Previous evidence suggests that a…”
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Independent Domains of Inhibitory Gating in Schizophrenia and the Effect of Stimulus Interval by Hong, L. Elliot, Summerfelt, Ann, Wonodi, Ikwunga, Adami, Helene, Buchanan, Robert W., Thaker, Gunvant K.

“…Objective: Patients with schizophrenia are known to have inhibitory gating deficits in the suppression of evoked potential P50 response to repeated stimuli and…”
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Cortical Kynurenine Pathway Metabolism: A Novel Target for Cognitive Enhancement in Schizophrenia by WONODI, Ikwunga, SCHWARCZ, Robert

“…The brain concentration of kynurenic acid (KYNA), a metabolite of the kynurenine pathway of tryptophan degradation and antagonist at both the glycine coagonist…”
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Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia by Sathyasaikumar, Korrapati V., Stachowski, Erin K., Wonodi, Ikwunga, Roberts, Rosalinda C., Rassoulpour, Arash, McMahon, Robert P., Schwarcz, Robert

“…The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan degradation and antagonist of α7…”
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Lack of association between COMT gene and deficit/nondeficit schizophrenia by Wonodi, Ikwunga, Mitchell, Braxton D, Stine, O Colin, Hong, L Elliot, Elliott, Amie, Kirkpatrick, Brian, Carpenter, Jr, William T, Thaker, Gunvant K, Buchanan, Robert W

“…The dopamine dysregulation hypothesis of schizophrenia posits that positive, negative and cognitive symptoms correlate with cortical/subcortical imbalances in…”
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Association between Val108/158 met polymorphism of the COMT gene and schizophrenia by Wonodi, Ikwunga, Stine, O. Colin, Mitchell, Braxton D., Buchanan, Robert W., Thaker, Gunvant K.

“…Schizophrenia is a complex disorder with a multifactorial polygenic inheritance with several genes conferring susceptibility at many genetic locations, each…”
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Clozapine and neutrophil response in patients of African descent: A six-month, multinational, prospective, open-label clinical trial by Kelly, Deanna L., Glassman, Matthew, Wonodi, Ikwunga, Vyas, Gopal, Richardson, Charles M., Nwulia, Evaristus, Wehring, Heidi J., Oduguwa, Taiwo, Mackowick, Marie, Hipolito, Maria Mananita S., Peters, Olawunmi, Rai, Narayan, Park, Jaeboon, Adebayo, Adeola O., Gorelick, David A., Weiner, Elaine, Liu, Fang, Kearns, Ann Marie, Adams, Heather A., Love, Raymond C., Chen, Shuo, Olaniyan, Ayodeji, Ambulos, Nicholas, McKoy, Darius, Nallani, Madhulika C., Lanzkron, Sophie, Mengistab, Mulu, Barr, Brian, Davis, Erica, Lawal, Rahman, Buchanan, Robert W., Adebayo, Richard

“…Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, but it is markedly underutilized, particularly in the US Black population,…”
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Influence of kynurenine 3-monooxygenase ( KMO ) gene polymorphism on cognitive function in schizophrenia by Wonodi, Ikwunga, McMahon, Robert P, Krishna, Nithin, Mitchell, Braxton D, Liu, Judy, Glassman, Matthew, Elliot Hong, L, Gold, James M

“…Abstract Background Cognitive deficits compromise quality of life and productivity for individuals with schizophrenia and have no effective treatments…”
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120. Benign Ethnic Neutropenia in a Sample of Nigerian Healthy Controls and Clozapine-Treated Schizophrenia Patients With DARC Null Variant by Wonodi, Ikwunga, Oduguwa, Taiwo, Amoo, Isiaka, Adebayo, Adeola, Adebimpe, Titilope, Kalejaiye, Olufunto, Adebayo, Richard, Lawal, Rahmaan, Peters, Olawunmi, Olaniyan, Ayodeji, Vyas, Gopal, Richardson, Charles, Glassman, Matthew, Kelly, Deanna

“…Background: Benign ethnic neutropenia (BEN) is the occurrence of absolute neutrophil counts (ANC) of less than 1500 cells/mm 3 observed in 10% to 30% of…”
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F56PRELIMINARY GENETIC ASSOCIATION ANALYSIS OF AN EYETRACKING ENDOPHENOTYPE IN A NIGERIAN FIRST-EPISODE SCHIZOPHRENIA SAMPLE by Adegbohun, Abosede, Oduguwa, Taiwo, Adebayo, Richard, Amoo, Isiaka, Liu, Judy, Glassman, Matthew, Summerfelt, Ann, Adebayo, Adeola, Olaniyan, Ayodeji, Adebimpe, Titilope, Kalejaiye, Olufunto, Peters, Olawunmi, Lawal, Rahmaan, Iyegbe, Conrad, Wonodi, Ikwunga

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Clozapine in Reducing Aggression and Violence in Forensic Populations by Patchan, Kathleen, Vyas, Gopal, Hackman, Ann L., Mackowick, Marie, Richardson, Charles M., Love, Raymond C., Wonodi, Ikwunga, Sayer, MacKenzie A., Glassman, Matthew, Feldman, Stephanie, Kelly, Deanna L.

“…Popular media often portray people with a mental illness as being aggressive, violent, and incarcerated as a result of their behavior. Despite exaggeration in…”
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Nicotine Enhances but Does Not Normalize Visual Sustained Attention and the Associated Brain Network in Schizophrenia by ELLIOT HONG, L, SCHROEDER, Matthew, ROSS, Thomas J, BUCHHOLZ, Brittany, JO SALMERON, Betty, WONODI, Ikwunga, THAKER, Gunvant K, STEIN, Elliot A

“…Sustained attention abnormality in schizophrenia is usually refractory to available treatment. Nicotine can transiently improve sustained attention in…”
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Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia by Hong, L. Elliot, Wonodi, Ikwunga, Avila, Matthew T., Buchanan, Robert W., McMahon, Robert P., Mitchell, Braxton D., Stine, O. Colin, Carpenter Jr, William T., Thaker, Gunvant K.

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Adjunctive Risperidone for Partially Responsive People with Schizophrenia Treated with Clozapine by WEINER, Elaine, CONLEY, Robert R, PATRICIA BALL, M, FELDMAN, Stephanie, GOLD, James M, KELLY, Deanna L, WONODI, Ikwunga, MCMAHON, Robert P, BUCHANAN, Robert W

“…The large numbers of partial clozapine responders represent a major therapeutic challenge. Unfortunately, there are no clear data to support how best to treat…”
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Dipyridamole monotherapy in schizophrenia: Pilot of a novel treatment approach by modulation of purinergic signaling by Wonodi, Ikwunga, Gopinath, Hirekatur V., Liu, Judy, Adami, Helene, Hong, L. Elliot, Allen-Emerson, Robert, McMahon, Robert P., Thaker, Gunvant K.

“…Background Emerging data indicate the neuromodulator adenosine may play a role in the therapeutics of schizophrenia. Adenosine A 2A receptor stimulation exerts…”
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A CHRNA5 allele related to nicotine addiction and schizophrenia by Hong, L. E., Yang, X., Wonodi, I., Hodgkinson, C. A., Goldman, D., Stine, O. C., Stein, E. S., Thaker, G. K.

“…Schizophrenia and nicotine addiction are both highly heritable phenotypes. Because individuals with schizophrenia have a higher rate of smoking than those in…”
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Refining the Predictive Pursuit Endophenotype in Schizophrenia by Hong, L. Elliot, Turano, Kathleen A, O’Neill, Hugh, Hao, Lei, Wonodi, Ikwunga, McMahon, Robert P, Elliott, Amie, Thaker, Gunvant K

“…Background To utilize fully a schizophrenia endophenotype in gene search and subsequent neurobiological studies, it is critical that the precise underlying…”
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Tardive dyskinesia in children treated with atypical antipsychotic medications by Wonodi, Ikwunga, Reeves, Gloria, Carmichael, Dana, Verovsky, Ilene, Avila, Matthew T., Elliott, Amie, Hong, L. Elliot, Adami, Helene M., Thaker, Gunvant K.

“…Recent years have witnessed increased antipsychotic treatment of children despite limited long‐term safety data in children. In this study, motor side effects…”
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