Search Results - "Wong, William G"

Modulation of Glucose Metabolism in Hippocampal Neurons by Adiponectin and Resistin by Cisternas, Pedro, Martinez, Milka, Ahima, Rexford S., William Wong, G., Inestrosa, Nibaldo C.

“…Obese individuals exhibit altered circulating levels of adipokines, the proteins secreted by adipose tissue to mediate tissue cross-talk and regulate appetite…”
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Metabolic function of the CTRP family of hormones by Seldin, Marcus M., Tan, Stefanie Y., Wong, G. William

“…Maintaining proper energy balance in mammals entails intimate crosstalk between various tissues and organs. These inter-organ communications are mediated, to a…”
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Myonectin deletion promotes adipose fat storage and reduces liver steatosis by Little, Hannah C., Rodriguez, Susana, Lei, Xia, Tan, Stefanie Y., Stewart, Ashley N., Sahagun, Ageline, Sarver, Dylan C., William Wong, G.

“…ABSTRACT We recently described myonectin (also known as erythroferrone) as a novel skeletal muscle‐derived myokine with metabolic functions. Here, we use a…”
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CTRP1 Protein Enhances Fatty Acid Oxidation via AMP-activated Protein Kinase (AMPK) Activation and Acetyl-CoA Carboxylase (ACC) Inhibition by Peterson, Jonathan M., Aja, Susan, Wei, Zhikui, Wong, G. William

“…We previously described the adipokine CTRP1, which has up-regulated expression following exposure to the anti-diabetic drug rosiglitazone and increased…”
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Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions by Wong, G William, Krawczyk, Sarah A, Kitidis-Mitrokostas, Claire, Revett, Tracy, Gimeno, Ruth, Lodish, Harvey F

“…The insulin-sensitizing hormone, adiponectin, belongs to the expanding C1q/TNF (tumour necrosis factor) family of proteins. We recently identified a family of…”
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PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains by Gao, Xinxin, Lowry, Pamela R, Zhou, Xin, Depry, Charlene, Wei, Zhikui, Wong, G. William, Zhang, Jin

“…Spatial compartmentalization of signaling pathway components generally defines the specificity and enhances the efficiency of signal transduction. The…”
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Dynamic Visualization of mTORC1 Activity in Living Cells by Zhou, Xin, Clister, Terri L., Lowry, Pamela R., Seldin, Marcus M., Wong, G. William, Zhang, Jin

“…The mechanistic target of rapamycin complex 1 (mTORC1) senses diverse signals to regulate cell growth and metabolism. It has become increasingly clear that…”
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CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism by Peterson, Jonathan M, Seldin, Marcus M, Wei, Zhikui, Aja, Susan, Wong, G William

“…CTRP3 is a secreted plasma protein of the C1q family that helps regulate hepatic gluconeogenesis and is downregulated in a diet-induced obese state. However,…”
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Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice by Wei, Zhikui, Lei, Xia, Petersen, Pia S, Aja, Susan, Wong, G William

“…Transgenic overexpression of CTRP9, a secreted hormone downregulated in obesity, confers striking protection against diet-induced obesity and type 2 diabetes…”
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Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes by Yang, Haojun, Ralle, Martina, Wolfgang, Michael J, Dhawan, Neha, Burkhead, Jason L, Rodriguez, Susana, Kaplan, Jack H, Wong, G William, Haughey, Norman, Lutsenko, Svetlana

“…Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown…”
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Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes by Multhaup, Michael L., Seldin, Marcus M., Jaffe, Andrew E., Lei, Xia, Kirchner, Henriette, Mondal, Prosenjit, Li, Yuanyuan, Rodriguez, Varenka, Drong, Alexander, Hussain, Mehboob, Lindgren, Cecilia, McCarthy, Mark, Näslund, Erik, Zierath, Juleen R., Wong, G. William, Feinberg, Andrew P.

“…Using a functional approach to investigate the epigenetics of type 2 diabetes (T2D), we combine three lines of evidence—diet-induced epigenetic dysregulation…”
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Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition by Sarver, Dylan C, Garcia-Diaz, Jean, Saqib, Muzna, Riddle, Ryan C, Wong, G William

“…Genome-wide association studies (GWAS) have identified a large number of candidate genes believed to affect longitudinal bone growth and bone mass. One of…”
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C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure by Appari, Mahesh, Breitbart, Astrid, Brandes, Florian, Szaroszyk, Malgorzata, Froese, Natali, Korf-Klingebiel, Mortimer, Mohammadi, Mona Malek, Grund, Andrea, Scharf, Gesine M, Wang, Honghui, Zwadlo, Carolin, Fraccarollo, Daniela, Schrameck, Ulrike, Nemer, Mona, Wong, G William, Katus, Hugo A, Wollert, Kai C, Müller, Oliver J, Bauersachs, Johann, Heineke, Joerg

“…RATIONALE:Myocardial endothelial cells promote cardiomyocyte hypertrophy, possibly through the release of growth factors. The identity of these factors,…”
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C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway by Zheng, Qijun, Yuan, Yuexing, Yi, Wei, Lau, Wayne Bond, Wang, Yajing, Wang, Xiaoliang, Sun, Yang, Lopez, Bernard L, Christopher, Theodore A, Peterson, Jonathan M, Wong, G William, Yu, Shiqiang, Yi, Dinghua, Ma, Xin-Liang

“…OBJECTIVE—Reduced plasma adiponectin (APN) in diabetic patients is associated with endothelial dysfunction. However, APN knockout animals manifest modest…”
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Loss of CTRP1 disrupts glucose and lipid homeostasis by Rodriguez, Susana, Lei, Xia, Petersen, Pia S, Tan, Stefanie Y, Little, Hannah C, Wong, G William

“…C1q/TNF-related protein 1 (CTRP1) is a conserved plasma protein of the C1q family with notable metabolic and cardiovascular functions. We have previously shown…”
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CTRP3 deficiency reduces liver size and alters IL-6 and TGFβ levels in obese mice by Wolf, Risa M, Lei, Xia, Yang, Zhi-Chun, Nyandjo, Maeva, Tan, Stefanie Y, Wong, G William

“…C1q/TNF-related protein 3 (CTRP3) is a secreted metabolic regulator whose circulating levels are reduced in human and rodent models of obesity and diabetes…”
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Skeletal Muscle-derived Myonectin Activates the Mammalian Target of Rapamycin (mTOR) Pathway to Suppress Autophagy in Liver by Seldin, Marcus M., Lei, Xia, Tan, Stefanie Y., Stanson, Kevin P., Wei, Zhikui, Wong, G. William

“…Cells turn on autophagy, an intracellular recycling pathway, when deprived of nutrients. How autophagy is regulated by hormonal signals in response to major…”
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CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction by Peterson, Jonathan M, Wei, Zhikui, Seldin, Marcus M, Byerly, Mardi S, Aja, Susan, Wong, G William

“…CTRP9 is a secreted multimeric protein of the C1q family and the closest paralog of the insulin-sensitizing adipokine, adiponectin. The metabolic function of…”
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Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity: A Cross-Sectional Study by Wolf, Risa M, Steele, Kimberley E, Peterson, Leigh A, Magnuson, Thomas H, Schweitzer, Michael A, Wong, G William

“…C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that lowers blood glucose levels, reduces liver triglyceride synthesis, and is protective against…”
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Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion by Hamoud, Noumeira, Tran, Viviane, Aimi, Takahiro, Kakegawa, Wataru, Lahaie, Sylvie, Thibault, Marie-Pier, Pelletier, Ariane, Wong, G. William, Kim, In-San, Kania, Artur, Yuzaki, Michisuke, Bouvier, Michel, Côté, Jean-François

“…Myoblast fusion is tightly regulated during development and regeneration of muscle fibers. BAI3 is a receptor that orchestrates myoblast fusion via Elmo/Dock1…”
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