Search Results - "Wong, W. L."

Linear ubiquitination prevents inflammation and regulates immune signalling by Gerlach, Björn, Cordier, Stefanie M., Schmukle, Anna C., Emmerich, Christoph H., Rieser, Eva, Haas, Tobias L., Webb, Andrew I., Rickard, James A., Anderton, Holly, Wong, Wendy W.-L., Nachbur, Ueli, Gangoda, Lahiru, Warnken, Uwe, Purcell, Anthony W., Silke, John, Walczak, Henning

“…Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in immunity and inflammation. Recently linear ubiquitin chains…”
Get full text

Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food by Dearden, Laura, Furigo, Isadora C, Pantaleão, Lucas C, Wong, L W P, Fernandez-Twinn, Denise S, de Almeida-Faria, Juliana, Kentistou, Katherine A, Carreira, Maria V, Bidault, Guillaume, Vidal-Puig, Antonio, Ong, Ken K, Perry, John R B, Donato, Jr, Jose, Ozanne, Susan E

“…In utero exposure to maternal obesity programs increased obesity risk. Animal models show that programmed offspring obesity is preceded by hyperphagia, but the…”
Get full text

A province-by-province cost-effectiveness analysis and budget impact analysis of one-time birth cohort screening of hepatitis C virus (HCV) infection in Canada by Wong, William W. L., Haines, Alex, Wong, Josephine, Hamadeh, Abdullah, Krahn, Murray D.

“…Managing chronic hepatitis C is challenging, as the majority of those infected are asymptomatic. Therefore, to ensure treatments are administered before the…”
Get full text

Synthesis and Preclinical Evaluation of Three Novel 68Ga-Labeled Bispecific PSMA/FAP-Targeting Tracers for Prostate Cancer Imaging by Verena, Arsyangela, Zhang, Zhengxing, Kuo, Hsiou-Ting, Merkens, Helen, Zeisler, Jutta, Wilson, Ryan, Bendre, Shreya, Wong, Antonio A. W. L., Bénard, François, Lin, Kuo-Shyan

“…Tumor heterogeneity limits the efficacy and reliability of monospecific radiopharmaceuticals in prostate cancer diagnosis and therapy. To overcome this…”
Get full text

MicroRNA-223 Is Commonly Repressed in Hepatocellular Carcinoma and Potentiates Expression of Stathmin1 by Wong, Queenie W.–L, Lung, Raymond W.–M, Law, Priscilla T.–Y, Lai, Paul B.–S, Chan, Kathy Y.–Y, To, Ka–Fai, Wong, Nathalie

“…Background & Aims: Recent studies have emphasized causative links between microRNA (miRNA) deregulations and cancer development. In hepatocellular carcinoma…”
Get full text

HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis by WONG, W. W.-L, DIMITROULAKOS, J, MINDEN, M. D, PENN, L. Z

“…The statin family of drugs target HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway, and have been used successfully in the treatment of…”
Get full text

Early predictors of dyslexia in Chinese children: familial history of dyslexia, language delay, and cognitive profiles by McBride-Chang, Catherine, Lam, Fanny, Lam, Catherine, Chan, Becky, Fong, Cathy Y.-C., Wong, Terry T.-Y., Wong, Simpson W.-L.

“…Background:  This work tested the rates at which Chinese children with either language delay or familial history of dyslexia at age 5 manifested dyslexia at…”
Get full text

Synthesis and Preclinical Evaluation of Two Novel 68Ga-Labeled Bispecific PSMA/FAP-Targeted Tracers with 2-Nal-Containing PSMA-Targeted Pharmacophore and Pyridine-Based FAP-Targeted Pharmacophore by Verena, Arsyangela, Merkens, Helen, Chen, Chao-Cheng, Chapple, Devon E., Wang, Lei, Bendre, Shreya, Wong, Antonio A. W. L., Bénard, François, Lin, Kuo-Shyan

“…Some bispecific radiotracers have been developed to overcome the limitations of monospecific tracers and improve detection sensitivity for heterogeneous tumor…”
Get full text

Effects and safety of vagus nerve stimulation on upper limb function in patients with stroke: a systematic review and meta-analysis by Abdullahi, Auwal, Wong, Thomson W. L., Ng, Shamay S. M.

“…Vagus nerve stimulation (VNS) is used to deliver electric current to stimulate the vagus nerve. The aim of this study is to carry out a systematic review and…”
Get full text

Semiautomated pipeline for quantitative analysis of heart histopathology by Droste, Patrick, Wong, Dickson W. L, Hohl, Mathias, von Stillfried, Saskia, Klinkhammer, Barbara M, Boor, Peter

“…Abstract Background Heart diseases are among the leading causes of death worldwide, many of which lead to pathological cardiomyocyte hypertrophy and capillary…”
Get full text

Assessing the level of perceived social support among community-dwelling stroke survivors using the Multidimensional Scale of Perceived Social Support by Ng, Shamay S. M., Liu, Tai Wa, Ho, Lily Y. W., Chan, Nga Huen, Wong, Thomson W. L., Tsoh, Joshua

“…Social support has an important role in stroke rehabilitation. The Multidimensional Scale of Perceived Social Support (MSPSS) is an instrument examining the…”
Get full text

Development of Mg/Cu nanocomposites using microwave assisted rapid sintering by Wong, W.L.E., Gupta, M.

“…In the present study, magnesium composites containing different amounts of nano-size Cu particulates were successfully synthesized using powder metallurgy (PM)…”
Get full text

A model-based framework for chronic hepatitis C prevalence estimation by Hamadeh, Abdullah, Feng, Zeny, Krahn, Murray, Wong, William W L

“…Chronic hepatitis C (CHC) continues to be a highly burdensome disease worldwide. The often-asymptomatic nature of early-stage CHC means that the disease often…”
Get full text

Synthesis and Evaluation of 68Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging by Bendre, Shreya, Zhang, Zhengxing, Colpo, Nadine, Zeisler, Jutta, Wong, Antonio A. W. L., Bénard, François, Lin, Kuo-Shyan

“…Fibroblast activation protein α (FAP-α) is a cell-surface protein overexpressed on cancer-associated fibroblasts that constitute a substantial component of…”
Get full text

To PET or not to PET? That is the question. Staging in anal cancer by Bhuva, N.J., Glynne-Jones, R., Sonoda, L., Wong, W.-L., Harrison, M.K.

“…Anal cancer is a rare tumour accounting for ∼2% of all colorectal cancers between 1997 and 2000 in the UK. Staging is still dominated by DRE (digital rectal…”
Get full text

Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer by Kang, Wei, Tong, Joanna H M, Chan, Anthony W H, Lung, Raymond W M, Chau, Shuk Ling, Wong, Queenie W L, Wong, Nathalie, Yu, Jun, Cheng, Alfred S L, To, Ka Fai

“…Stathmin1 (STMN1) is a candidate oncoprotein and prognosis marker in several kinds of cancers. This study was aimed to analyze its expression and biological…”
Get full text

Effect of digital ocular massage on intraocular pressure and Schlemm’s canal dimensions by Wu, Tiffany H. Y., Lau, Henry K. C., Lai, Carmelo H. Y., Wong, Ruby W. L., Wong, Antonia K. W., Lam, Andrew Kwok-cheung

“…Digital ocular massage has been reported to temporarily lower intraocular pressure (IOP). This could be related to an enhanced aqueous humor outflow; however,…”
Get full text

Fine Tuning the Performance of Multiorbital Radical Conductors by Substituent Effects by Mailman, Aaron, Wong, Joanne W. L, Winter, Stephen M, Claridge, Robert C. M, Robertson, Craig M, Assoud, Abdeljalil, Yong, Wenjun, Steven, Eden, Dube, Paul A, Tse, John S, Desgreniers, Serge, Secco, Richard A, Oakley, Richard T

“…A critical feature of the electronic structure of oxobenzene-bridged bisdithiazolyl radicals 2 is the presence of a low-lying LUMO which, in the solid state,…”
Get full text

MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma by LAW, Priscilla T.-Y, CHING, Arthur K.-K, CHAN, Anthony W.-H, WONG, Queenie W.-L, WONG, Chun-Kwok, TO, Ka-Fai, WONG, Nathalie

“…Profiling of microRNA expression in human cancers has highlighted downregulation of miR-145 as a common event in epithelial malignancies. Here, we describe…”
Get full text

The impact of the early COVID-19 pandemic on healthcare system resource use and costs in two provinces in Canada: An interrupted time series analysis by Zeitouny, Seraphine, Cheung, Douglas C, Bremner, Karen E, Pataky, Reka E, Pequeno, Priscila, Matelski, John, Peacock, Stuart, Del Giudice, M. Elisabeth, Lapointe-Shaw, Lauren, Tomlinson, George, Mendlowitz, Andrew B, Mulder, Carol, Tsui, Teresa C. O, Perlis, Nathan, Walker, Jennifer D, Sander, Beate, Wong, William W. L, Krahn, Murray D, Kulkarni, Girish S

“…Introduction The aim of our study was to assess the initial impact of COVID-19 on total publicly-funded direct healthcare costs and health services use in two…”
Get full text