Search Results - "Wong, W S Fred"

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD by Footitt, Joseph, PhD, Mallia, Patrick, PhD, Durham, Andrew L., PhD, Ho, W. Eugene, PhD, Trujillo-Torralbo, Maria-Belen, BSc, Telcian, Aurica G., PhD, Del Rosario, Ajerico, BSc, Chang, Cheng, PhD, Peh, Hong-Yong, MSc, Kebadze, Tatiana, MD, Aniscenko, Julia, Stanciu, Luminita, PhD, Essilfie-Quaye, Sarah, PhD, Ito, Kazuhiro, PhD, Barnes, Peter J., FCCP, Elkin, Sarah L., PhD, Kon, Onn M., MD, Wong, W. S. Fred, PhD, Adcock, Ian M., PhD, Johnston, Sebastian L., PhD

“…Background Respiratory virus infections are commonly associated with COPD exacerbations, but little is known about the mechanisms linking virus infection to…”
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Receptor-interacting protein 2 gene silencing attenuates allergic airway inflammation by Goh, Fera Y, Cook, Katrina L T P, Upton, Nadine, Tao, Lin, Lah, Lin Chin, Leung, Bernard P, Wong, W S Fred

“…Persistent activation of NF-κB has been associated with the development of asthma. Receptor-interacting protein 2 (Rip2) is a transcriptional product of NF-κB…”
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Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol by Peh, Hong Yong, Tan, W S Daniel, Liao, Wupeng, Wong, W S Fred

“…The discovery of vitamin E (α-tocopherol) began in 1922 as a vital component required in reproduction. Today, there are eight naturally occurring vitamin E…”
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Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases by Gan, Phyllis X.L., Zhang, Shanshan, Fred Wong, W.S.

“…[Display omitted] Metabolic reprogramming underlies the etiology and pathophysiology of respiratory diseases such as asthma, idiopathic pulmonary fibrosis…”
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Transcription factor E3, a major regulator of mast cell–mediated allergic response by Yagil, Zohar, PhD, Hadad Erlich, Tal, MSc, Ofir-Birin, Yifat, MSc, Tshori, Sagi, MD, PhD, Kay, Gillian, PhD, Yekhtin, Zanna, BSc, Fisher, David E., MD, PhD, Cheng, Chang, PhD, Wong, W. S. Fred, PhD, Hartmann, Karin, MD, Razin, Ehud, PhD, Nechushtan, Hovav, MD, PhD

“…Background Microphthalmia transcription factor, an MiT transcription family member closely related to transcription factor E3 (TFE3), is essential for mast…”
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ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice by Nguyen, Ngan, Xu, Simin, Lam, Terence Yin Weng, Liao, Wupeng, Wong, W. S. Fred, Ge, Ruowen

“…Abstract Background Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are clinical syndromes characterized by acute lung inflammation, pulmonary…”
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ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis by Lam, Terence Y W, Nguyen, Ngan, Peh, Hong Yong, Shanmugasundaram, Mahalakshmi, Chandna, Ritu, Tee, Jong Huat, Ong, Chee Bing, Hossain, Md Zakir, Venugopal, Shruthi, Zhang, Tianyi, Xu, Simin, Qiu, Tao, Kong, Wan Ting, Chakarov, Svetoslav, Srivastava, Supriya, Liao, Wupeng, Kim, Jin-Soo, Teh, Ming, Ginhoux, Florent, Fred Wong, W S, Ge, Ruowen

“…Alveolar macrophages (AMs) are critical for lung immune defense and homeostasis. They are orchestrators of chronic obstructive pulmonary disease (COPD), with…”
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Active p38α causes macrovesicular fatty liver in mice by Darlyuk-Saadon, Ilona, Bai, Chen, Heng, Chew Kiat Matthew, Gilad, Nechama, Yu, Wei-Ping, Lim, Pei Yen, Cazenave-Gassiot, Amaury, Zhang, Yongliang, Wong, W. S. Fred, Engelberg, David

“…One third of the western population suffers from nonalcoholic fatty liver disease (NAFLD), which may ultimately develop into hepatocellular carcinoma (HCC)…”
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Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells by Chan, Tze Khee, Tan, W S Daniel, Peh, Hong Yong, Wong, W S Fred

“…Exposure to environmental allergens is a major risk factor for asthma development. Allergens possess proteolytic activity that is capable of disrupting the…”
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Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage by Aswani, Andrew, Manson, Joanna, Itagaki, Kiyoshi, Chiazza, Fausto, Collino, Massimo, Wupeng, Winston Liao, Chan, Tze Khee, Wong, W S Fred, Hauser, Carl J, Thiemermann, Chris, Brohi, Karim

“…Trauma is a leading cause of death worldwide with 5.8 million deaths occurring yearly. Almost 40% of trauma deaths are due to bleeding and occur in the first…”
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Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-γ-Induced IL-27 and Airway Hyperresponsiveness in Mice by Liao, Wupeng, Tan, W S Daniel, Wong, W S Fred

“…LPS and IFN-γ alone or in combination have been implicated in the development of steroid resistance. Combined LPS/IFN-γ strongly upregulates IL-27 production,…”
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Metabolomics reveals altered metabolic pathways in experimental asthma by Ho, Wanxing Eugene, Xu, Yong-Jiang, Xu, Fengguo, Cheng, Chang, Peh, Hong Yong, Tannenbaum, Steven R, Wong, W S Fred, Ong, Choon Nam

“…Metabolomics refers to the comprehensive analysis of metabolites in biological systems, and has been employed to study patients with asthma based on their…”
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Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer by Lim, Jonathan Chee Woei, Chan, Tze Khee, Ng, David SW, Sagineedu, Sreenivasa R, Stanslas, Johnson, Wong, WS Fred

“…Summary 1. Andrographis paniculata (Burm. f) Nees, commonly known as ‘king of bitters’, is a herbaceous plant belonging to the Family Acanthaceae. It has been…”
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Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice by Tee, Jong Huat, Vijayakumar, Udhaya, Shanmugasundaram, Mahalakshmi, Lam, Terence Y. W, Liao, Wupeng, Yang, Yuansheng, Wong, W. S. Fred, Ge, Ruowen

“…Abstract Background Allergic asthma is a common respiratory disease that significantly impacts human health. Through in silico analysis of human lung RNASeq,…”
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Vitamin E Isoform γ-Tocotrienol Downregulates House Dust Mite-Induced Asthma by Peh, Hong Yong, Ho, Wanxing Eugene, Cheng, Chang, Chan, Tze Khee, Seow, Ann Ching Genevieve, Lim, Albert Y H, Fong, Chee Wai, Seng, Kok Yong, Ong, Choon Nam, Wong, W S Fred

“…Inflammation and oxidative damage contribute to the pathogenesis of asthma. Although corticosteroid is the first-line treatment for asthma, a subset of…”
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House dust mite–induced asthma causes oxidative damage and DNA double-strand breaks in the lungs by Chan, Tze Khee, BSc, Loh, Xin Yi, BSc, Peh, Hong Yong, BSc, Tan, W.N. Felicia, BSc, Tan, W.S. Daniel, BSc, Li, Na, PhD, Tay, Ian J.J., BEng, Wong, W.S. Fred, PhD, Engelward, Bevin P., ScD

“…Background Asthma is related to airway inflammation and oxidative stress. High levels of reactive oxygen and nitrogen species can induce cytotoxic DNA damage…”
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Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway by Cheng, Chang, Ho, W Eugene, Goh, Fera Y, Guan, Shou Ping, Kong, Li Ren, Lai, Wen-Qi, Leung, Bernard P, Wong, W S Fred

“…Phosphoinositide 3-kinase (PI3K)/Akt pathway is linked to the development of asthma. Anti-malarial drug artesunate is a semi-synthetic derivative of…”
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Expression of a constitutively active p38α mutant in mice causes early death, anemia, and accumulation of immunosuppressive cells by Darlyuk‐Saadon, Ilona, Heng, Chew Kiat Matthew, Bai, Chen, Gilad, Nechama, Yu, Wei‐Ping, Meng Huang Mok, Michelle, Wong, W.S. Fred, Engelberg, David

“…The MAP kinase p38α is associated with numerous processes in eukaryotes, and its elevated activity is a prominent feature of inflammatory diseases, allergies,…”
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Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia by Chan, Su Jing, Wong, WS Fred, Wong, Peter TH, Bian, Jin‐Song

“…BACKGROUND AND PURPOSE Andrographolide is a diterpenoid lactone isolated from a traditional medicinal herb, Andrographis paniculata. It possesses potent…”
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Anti-Inflammatory Effects of Mitogen-Activated Protein Kinase Kinase Inhibitor U0126 in an Asthma Mouse Model by Duan, Wei, Chan, Jasmine H. P, Wong, Chui Hong, Leung, Bernard P, Wong, W. S. Fred

“…Mitogen-activated protein kinase (MAPK) signaling cascade plays a pivotal role in the activation of inflammatory cells. Recent findings revealed that the…”
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