Search Results - "Wong, Tzutshin"

Serendipitous discovery of an unexpected rearrangement leads to two new classes of potential protease inhibitors by Zhong, Jiaying, Lai, Zhong, Groutas, Christopher S., Wong, Tzutshin, Gan, Xiangdong, Alliston, Kevin R., Eichhorn, David, Hoidal, John R., Groutas, William C.

“…[Display omitted] The pathogenesis of a range of human diseases arises from the aberrant activity of proteolytic enzymes. Agents capable of selectively…”
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1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase by Wong, Tzutshin, Groutas, Christopher S., Mohan, Swathi, Lai, Zhong, Alliston, Kevin R., Vu, Nga, Schechter, Norman M., Groutas, William C.

“…We describe herein the design, synthesis, and in vitro biochemical evaluation of a series of potent, time-dependent inhibitors of the mast cell-derived serine…”
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Potential Protease Inhibitors Based on a Functionalized Cyclic Sulfamide Scaffold by Zhong, Jiaying, Gan, Xiangdong, Alliston, Kevin R, Lai, Zhong, Yu, Hongyi, Groutas, Christopher S, Wong, Tzutshin, Groutas, William C

“…Exploratory studies related to the design and synthesis of functionalized cyclic sulfamides (I) as potential inhibitors of proteolytic enzymes were carried…”
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