Search Results - "Wong, Ting Y"

Longitudinal temperature measurement can determine humane endpoints in BALB/c mouse models of ESKAPEE infection by Dudis, Randal Scott, Wong, Ting Y., Escatte, Mariel G., Alamneh, Yonas A., Abu-Taleb, Rania, Su, Wanwen, Czintos, Christine, Fitzgerald, Timothy A., Le Breton, Yoann, Zurawski, Daniel V.

“…Antimicrobial resistance (AMR) is a worldwide problem, which is driving more preclinical research to find new treatments and countermeasures for drug-resistant…”
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Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge by Weaver, Kelly L, Bitzer, Graham J, Wolf, M Allison, Pyles, Gage M, DeJong, Megan A, Dublin, Spencer R, Huckaby, Annalisa B, Gutierrez, Maria de la Paz, Hall, Jesse M, Wong, Ting Y, Warden, Matthew, Petty, Jonathan E, Witt, William T, Cunningham, Casey, Sen-Kilic, Emel, Damron, F Heath, Barbier, Mariette

“…The murine Bordetella pertussis challenge model has been utilized in preclinical research for decades. Currently, inconsistent methodologies are employed by…”
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Intranasal Peptide-Based FpvA-KLH Conjugate Vaccine Protects Mice From Pseudomonas aeruginosa Acute Murine Pneumonia by Sen-Kilic, Emel, Blackwood, Catherine B, Boehm, Dylan T, Witt, William T, Malkowski, Aaron C, Bevere, Justin R, Wong, Ting Y, Hall, Jesse M, Bradford, Shelby D, Varney, Melinda E, Damron, Fredrick Heath, Barbier, Mariette

“…is an opportunistic pathogen causing acute and chronic respiratory infections associated with morbidity and mortality, especially in patients with cystic…”
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Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection by Diallo, Béré K., Ní Chasaide, Caitlín, Wong, Ting Y., Schmitt, Pauline, Lee, Katherine S., Weaver, Kelly, Miller, Olivia, Cooper, Melissa, Jazayeri, Seyed D., Damron, F. Heath, Mills, Kingston H. G.

“…Current COVID-19 vaccines prevent severe disease, but do not induce mucosal immunity or prevent infection with SARS-CoV-2, especially with recent variants…”
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Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2 by Barbier, Mariette, Lee, Katherine S., Vikharankar, Mayur S., Rajpathak, Shriram N., Kadam, Nandkumar, Wong, Ting Y., Russ, Brynnan P., Cyphert, Holly A., Miller, Olivia A., Rader, Nathaniel A., Cooper, Melissa, Kang, Jason, Sen-Kilic, Emel, Wong, Zeriel Y., Winters, Michael T., Bevere, Justin R., Martinez, Ivan, Devarumath, Rachayya, Shaligram, Umesh S., Damron, F. Heath

“…Emergence of variants of concern (VOC) during the COVID-19 pandemic has contributed to the decreased efficacy of therapeutic monoclonal antibody treatments for…”
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Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge by Wong, Ting Y., Lee, Katherine S., Russ, Brynnan P., Horspool, Alexander M., Kang, Jason, Winters, Michael T., Allison Wolf, M., Rader, Nathaniel A., Miller, Olivia A., Shiflett, Morgane, Izac, Jerilyn, Varisco, David, Sen-Kilic, Emel, Cunningham, Casey, Cooper, Melissa, Cyphert, Holly A., Barbier, Mariette, Martinez, Ivan, Bevere, Justin R., Ernst, Robert K., Damron, F. Heath

“…SARS-CoV-2 is a viral respiratory pathogen responsible for the current global pandemic and the disease that causes COVID-19. All current WHO approved COVID-19…”
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Influenza virus strains expressing SARS-CoV-2 receptor binding domain protein confer immunity in K18-hACE2 mice by Rader, Nathaniel A., Lee, Katherine S., Loes, Andrea N., Miller-Stump, Olivia A., Cooper, Melissa, Wong, Ting Y., Boehm, Dylan T., Barbier, Mariette, Bevere, Justin R., Heath Damron, F.

“…•ΔNA(RBD) is an influenza virus-based vaccine for SARS-CoV-2.•ΔNA(RBD) is genetically engineered to express RBD in the NA gene locus.•Infected mice vaccinated…”
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Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2 by Lee, Katherine S., Russ, Brynnan P., Wong, Ting Y., Horspool, Alexander M., Winters, Michael T., Barbier, Mariette, Bevere, Justin R., Martinez, Ivan, Damron, F. Heath, Cyphert, Holly A.

“…Severe outcomes from SARS-CoV-2 infection are highly associated with preexisting comorbid conditions like hypertension, diabetes, and obesity. We utilized the…”
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Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice by Wolf, M. Allison, O’Hara, Joanne M., Bitzer, Graham J., Narayanan, Elisabeth, Boehm, Dylan T., Bevere, Justin R., DeJong, Megan A., Hall, Jesse M., Wong, Ting Y., Falcone, Samantha, Deal, Cailin E., Richards, Angelene, Green, Shannon, Nguyen, Brenda, King, Emily, Ogega, Clinton, Russo, Lisa, Sen-Kilic, Emel, Plante, Obadiah, Himansu, Sunny, Barbier, Mariette, Carfi, Andrea, Damron, F. Heath

“…Acellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease and infant mortality, but immunity to Bordetella pertussis infection…”
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Bordetella pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naïve Infection by Driving Hematopoietic Stem and Progenitor Cell Expansion in Mice by Varney, Melinda E, Boehm, Dylan T, DeRoos, Katherine, Nowak, Evan S, Wong, Ting Y, Sen-Kilic, Emel, Bradford, Shebly D, Elkins, Cody, Epperly, Matthew S, Witt, William T, Barbier, Mariette, Damron, F Heath

“…Hematopoietic stem and progenitor cell (HSPC) compartments are altered to direct immune responses to infection. Their roles during immunization are not…”
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Innate and Adaptive Immune Responses against Bordetella pertussis and Pseudomonas aeruginosa in a Murine Model of Mucosal Vaccination against Respiratory Infection by Blackwood, Catherine B, Sen-Kilic, Emel, Boehm, Dylan T, Hall, Jesse M, Varney, Melinda E, Wong, Ting Y, Bradford, Shelby D, Bevere, Justin R, Witt, William T, Damron, F Heath, Barbier, Mariette

“…Whole cell vaccines are frequently the first generation of vaccines tested for pathogens and can inform the design of subsequent acellular or subunit vaccines…”
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Cyclic di-GMP Regulates the Type III Secretion System and Virulence in Bordetella bronchiseptica by Gutierrez, María de la Paz, Wong, Ting Y, Damron, Fredrick Heath, Fernández, Julieta, Sisti, Federico

“…The second messenger cyclic di-GMP (c-di-GMP) is a ubiquitous molecule in bacteria that regulates diverse phenotypes. Among them, motility and biofilm…”
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Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice by Lee, Katherine S., Rader, Nathaniel A., Miller-Stump, Olivia A., Cooper, Melissa, Wong, Ting Y., Shahrier Amin, Md, Barbier, Mariette, Bevere, Justin R., Ernst, Robert K., Heath Damron, F.

“…As the COVID-19 pandemic transitions into endemicity, seasonal boosters are a plausible reality across the globe. We hypothesize that intranasal vaccines can…”
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CpG 1018® adjuvant enhances Tdap immune responses against Bordetella pertussis in mice by DeJong, Megan A., Wolf, M. Allison, Bitzer, Graham J., Hall, Jesse M., Sen-Kilic, Emel, Blake, Jeanna M., Petty, Jonathan E., Wong, Ting Y., Barbier, Mariette, Campbell, John D., Bevere, Justin R., Damron, F. Heath

“…Bordetella pertussis is the causative agent of whooping cough (pertussis), a severe respiratory disease that can be fatal, particularly in infants. Despite…”
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Mucosal Immunization with DTaP Confers Protection against Bordetella pertussis Infection and Cough in Sprague-Dawley Rats by Hall, Jesse M, Bitzer, Graham J, DeJong, Megan A, Kang, Jason, Wong, Ting Y, Wolf, M Allison, Bevere, Justin R, Barbier, Mariette, Damron, F Heath

“…Pertussis is a respiratory disease caused by the Gram-negative pathogen, Bordetella pertussis. The transition from a whole-cell pertussis vaccine (wP and DTP)…”
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Intranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice by Wolf, M Allison, Boehm, Dylan T, DeJong, Megan A, Wong, Ting Y, Sen-Kilic, Emel, Hall, Jesse M, Blackwood, Catherine B, Weaver, Kelly L, Kelly, Claire O, Kisamore, Caleb A, Bitzer, Graham J, Bevere, Justin R, Barbier, Mariette, Damron, F Heath

“…colonizes the respiratory mucosa of humans, inducing an immune response seeded in the respiratory tract. An individual, once convalescent, exhibits long-term…”
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Reinvestigating the Coughing Rat Model of Pertussis To Understand Bordetella pertussis Pathogenesis by Hall, Jesse M, Kang, Jason, Kenney, Sophia M, Wong, Ting Y, Bitzer, Graham J, Kelly, Claire O, Kisamore, Caleb A, Boehm, Dylan T, DeJong, Megan A, Wolf, M Allison, Sen-Kilic, Emel, Horspool, Alexander M, Bevere, Justin R, Barbier, Mariette, Damron, F Heath

“…Bordetella pertussis is a highly contagious bacterium that is the causative agent of whooping cough (pertussis). Currently, acellular pertussis vaccines (aP,…”
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SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice by Lee, Katherine S, Wong, Ting Y, Russ, Brynnan P, Horspool, Alexander M, Miller, Olivia A, Rader, Nathaniel A, Givi, Jerome P, Winters, Michael T, Wong, Zeriel Y A, Cyphert, Holly A, Denvir, James, Stoilov, Peter, Barbier, Mariette, Roan, Nadia R, Amin, Md Shahrier, Martinez, Ivan, Bevere, Justin R, Damron, F Heath

“…The COVID-19 pandemic has been fueled by SARS-CoV-2 novel variants of concern (VOC) that have increased transmissibility, receptor binding affinity, and other…”
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Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice by Boehm, Dylan T, Hall, Jesse M, Wong, Ting Y, DiVenere, Andrea M, Sen-Kilic, Emel, Bevere, Justin R, Bradford, Shelby D, Blackwood, Catherine B, Elkins, Cody M, DeRoos, Katherine A, Gray, Mary C, Cooper, C Garret, Varney, Melinda E, Maynard, Jennifer A, Hewlett, Erik L, Barbier, Mariette, Damron, F Heath

“…is the primary causative agent of pertussis (whooping cough), which is a respiratory infection that leads to a violent cough and can be fatal in infants. There…”
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Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice by Wong, Ting Y, Horspool, Alexander M, Russ, Brynnan P, Ye, Chengjin, Lee, Katherine S, Winters, Michael T, Bevere, Justin R, Miller, Olivia A, Rader, Nathaniel A, Cooper, Melissa, Kieffer, Theodore, Sourimant, Julien, Greninger, Alexander L, Plemper, Richard K, Denvir, James, Cyphert, Holly A, Barbier, Mariette, Torrelles, Jordi B, Martinez, Ivan, Martinez-Sobrido, Luis, Damron, F Heath

“…SARS-CoV-2 variants of concern (VoC) are impacting responses to the COVID-19 pandemic. Here, we utilized passive immunization using human convalescent plasma…”
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