Search Results - "Wong, Sunny Y."

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches by Peterson, Shelby C., Eberl, Markus, Vagnozzi, Alicia N., Belkadi, Abdelmadjid, Veniaminova, Natalia A., Verhaegen, Monique E., Bichakjian, Christopher K., Ward, Nicole L., Dlugosz, Andrzej A., Wong, Sunny Y.

“…Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for…”
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The fate of early perichondrial cells in developing bones by Matsushita, Yuki, Chu, Angel Ka Yan, Tsutsumi-Arai, Chiaki, Orikasa, Shion, Nagata, Mizuki, Wong, Sunny Y., Welch, Joshua D., Ono, Wanida, Ono, Noriaki

“…In endochondral bone development, bone-forming osteoblasts and bone marrow stromal cells have dual origins in the fetal cartilage and its surrounding…”
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Cilia-Associated Oxysterols Activate Smoothened by Raleigh, David R., Sever, Navdar, Choksi, Pervinder K., Sigg, Monika Abedin, Hines, Kelly M., Thompson, Bonne M., Elnatan, Daniel, Jaishankar, Priyadarshini, Bisignano, Paola, Garcia-Gonzalo, Francesc R., Krup, Alexis Leigh, Eberl, Markus, Byrne, Eamon F.X., Siebold, Christian, Wong, Sunny Y., Renslo, Adam R., Grabe, Michael, McDonald, Jeffrey G., Xu, Libin, Beachy, Philip A., Reiter, Jeremy F.

“…Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely…”
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Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration by Vagnozzi, Alicia N, Reiter, Jeremy F, Wong, Sunny Y

“…Upon wounding, multiple stem cell populations in the hair follicle (HF) and interfollicular epidermis (IFE) converge at the site of injury. Although these…”
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Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis by Reiter, Jeremy F, Wong, Sunny Y, Seol, Allen D, So, Po-Lin, Ermilov, Alexandre N, Bichakjian, Christopher K, Epstein, Ervin H, Dlugosz, Andrzej A

“…Primary cilia are present on most mammalian cells and are implicated in transducing Hedgehog (Hh) signals during development; however, the prevalence of cilia…”
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Wounding mobilizes hair follicle stem cells to form tumors by Wong, Sunny Y, Reiter, Jeremy F

“…A wide variety of human cancers are associated with injury. Although stem cells participate in tissue regeneration after wounding, it is unclear whether these…”
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Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations by Zouboulis, Christos C, Coenye, Tom, He, Li, Kabashima, Kenji, Kobayashi, Tetsuro, Niemann, Catherin, Nomura, Takashi, Oláh, Attila, Picardo, Mauro, Quist, Sven R, Sasano, Hironobu, Schneider, Marlon R, Törőcsik, Daniel, Wong, Sunny Y

“…This review presents several aspects of the innovative concept of sebaceous immunobiology, which summarizes the numerous activities of the sebaceous gland…”
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Hair Follicle Terminal Differentiation Is Orchestrated by Distinct Early and Late Matrix Progenitors by Mesler, Arlee L., Veniaminova, Natalia A., Lull, Madison V., Wong, Sunny Y.

“…During development and regeneration, matrix progenitors undergo terminal differentiation to form the concentric layers of the hair follicle. These…”
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Lymphatic or Hematogenous Dissemination: How Does a Metastatic Tumor Cell Decide? by Wong, Sunny Y., Hynes, Richard O.

“…The formation of distant metastases is the deadliest phase of cancer progression. Although numerous studies have identified genes and mechanisms that affect…”
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Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin by Veniaminova, Natalia A., Grachtchouk, Marina, Doane, Owen J., Peterson, Jamie K., Quigley, David A., Lull, Madison V., Pyrozhenko, Daryna V., Nair, Raji R., Patrick, Matthew T., Balmain, Allan, Dlugosz, Andrzej A., Tsoi, Lam C., Wong, Sunny Y.

“…Oil-secreting sebaceous glands (SGs) are critical for proper skin function; however, it remains unclear how different factors act together to modulate SG stem…”
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Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury by Veniaminova, Natalia A., Jia, Yunlong Y., Hartigan, Adrien M., Huyge, Thomas J., Tsai, Shih-Ying, Grachtchouk, Marina, Nakagawa, Seitaro, Dlugosz, Andrzej A., Atwood, Scott X., Wong, Sunny Y.

“…Sebaceous glands (SGs) release oils that protect our skin, but how these glands respond to injury has not been previously examined. Here, we report that SGs…”
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Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice by Verhaegen, Monique E, Harms, Paul W, Van Goor, Julia J, Arche, Jacob, Patrick, Matthew T, Wilbert, Dawn, Zabawa, Haley, Grachtchouk, Marina, Liu, Chia-Jen, Hu, Kevin, Kelly, Michael C, Chen, Ping, Saunders, Thomas L, Weidinger, Stephan, Syu, Li-Jyun, Runge, John S, Gudjonsson, Johann E, Wong, Sunny Y, Brownell, Isaac, Cieslik, Marcin, Udager, Aaron M, Chinnaiyan, Arul M, Tsoi, Lam C, Dlugosz, Andrzej A

“…Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and…”
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Hair follicles modulate skin barrier function by Ford, Noah C., Benedeck, Rachel E., Mattoon, Matthew T., Peterson, Jamie K., Mesler, Arlee L., Veniaminova, Natalia A., Gardon, Danielle J., Tsai, Shih-Ying, Uchida, Yoshikazu, Wong, Sunny Y.

“…Our skin provides a protective barrier that shields us from our environment. Barrier function is typically associated with the interfollicular epidermis;…”
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Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct by Swanson, Jacob B., Vagnozzi, Alicia N., Veniaminova, Natalia A., Wong, Sunny Y.

“…The uppermost aspect of the hair follicle, known as the infundibulum or hair canal, provides a passageway for hair shaft egress and sebum secretion. Recent…”
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A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development by Xiao, Ying, Thoresen, Daniel T, Miao, Lingling, Williams, Jonathan S, Wang, Chaochen, Atit, Radhika P, Wong, Sunny Y, Brownell, Isaac

“…The Sonic hedgehog (Shh) signaling pathway regulates developmental, homeostatic, and repair processes throughout the body. In the skin, touch domes develop in…”
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Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease by Trieu, Kenneth G., Tsai, Shih-Ying, Eberl, Markus, Ju, Virginia, Ford, Noah C., Doane, Owen J., Peterson, Jamie K., Veniaminova, Natalia A., Grachtchouk, Marina, Harms, Paul W., Swartling, Fredrik J., Dlugosz, Andrzej A., Wong, Sunny Y.

“…Basal cell carcinomas (BCCs) frequently possess immense mutational burdens; however, the functional significance of most of these mutations remains unclear…”
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Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis by WONG, Sunny Y, HAACK, Herbert, CROWLEY, Denise, BARRY, Marc, BRONSON, Roderick T, HYNES, Richard O

“…Dissemination to draining lymph nodes is a frequent first step in prostate cancer metastasis. Although tumors metastasize to lymph nodes via the lymphatics,…”
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Role of epidermal primary cilia in the homeostasis of skin and hair follicles by Croyle, Mandy J, Lehman, Jonathan M, O'Connor, Amber K, Wong, Sunny Y, Malarkey, Erik B, Iribarne, Daniela, Dowdle, William E, Schoeb, Trenton R, Verney, Zoe M, Athar, Mohammad, Michaud, Edward J, Reiter, Jeremy F, Yoder, Bradley K

“…Skin and hair follicle morphogenesis and homeostasis require the integration of multiple signaling pathways, including Hedgehog (Hh) and Wingless (Wnt), and…”
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Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells by SPASSOV, Danislav S, WONG, Ching Hang, WONG, Sunny Y, REITER, Jeremy F, MOASSER, Mark M

“…The cell surface glycoprotein Trask/CDCP1 is phosphorylated during anchorage loss in epithelial cells in which it inhibits integrin clustering, outside-in…”
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Use of Singapore’s “Standard Details of Road Elements” for distance estimation in traffic crash reconstruction: A comparison with onsite measurements and Google Earth Pro by Lee, Rui Lin, Wong, Grace M.E., Wong, Sunny Y.S., Koh, Alaric C.W.

“…We report the use of the geometric design standard for road markings published in the “Standard Details of Road Elements” (‘SDRE’) by the Land Transport…”
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