Search Results - "Wong, Stephen T C"

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription by Chahrour, Maria, Jung, Sung Yun, Shaw, Chad, Zhou, Xiaobo, Wong, Stephen T.C, Qin, Jun, Zoghbi, Huda Y

“…Mutations in the gene encoding the transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome. Loss of…”
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Combining deep learning and coherent anti-Stokes Raman scattering imaging for automated differential diagnosis of lung cancer by Weng, Sheng, Xu, Xiaoyun, Li, Jiasong, Wong, Stephen T. C

“…Lung cancer is the most prevalent type of cancer and the leading cause of cancer-related deaths worldwide. Coherent anti-Stokes Raman scattering (CARS) is…”
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Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis by Yeung, Tsz-Lun, Leung, Cecilia S, Yip, Kay-Pong, Au Yeung, Chi Lam, Wong, Stephen T C, Mok, Samuel C

“…Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late stage, with a 5-yr survival rate of <30%. The majority of ovarian…”
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Targeting ribosome biogenesis as a novel therapeutic approach to overcome EMT-related chemoresistance in breast cancer by Ban, Yi, Zou, Yue, Liu, Yingzhuo, Lee, Sharrel, Bednarczyk, Robert B, Sheng, Jianting, Cao, Yuliang, Wong, Stephen T C, Gao, Dingcheng

“…Epithelial-to-mesenchymal transition (EMT) contributes significantly to chemotherapy resistance and remains a critical challenge in treating advanced breast…”
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Old Drug New Use―Amoxapine and Its Metabolites as Potent Bacterial β-Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity by REN KONG, LIU, Timothy, XIAOPING ZHU, AHMAD, Syed, WILLIAMS, Alfred L, PHAN, Alexandria T, HONG ZHAO, SCOTT, John E, YEH, Li-An, WONG, Stephen T. C

“…Irinotecan (CPT-11) induced diarrhea occurs frequently in patients with cancer and limits its usage. Bacteria β-glucuronidase (GUS) enzymes in intestines…”
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An AI-driven clinical care pathway to reduce 30-day readmission for chronic obstructive pulmonary disease (COPD) patients by Wang, Lin, Li, Guihua, Ezeana, Chika F., Ogunti, Richard, Puppala, Mamta, He, Tiancheng, Yu, Xiaohui, Wong, Solomon S. Y., Yin, Zheng, Roberts, Aaron W., Nezamabadi, Aryan, Xu, Pingyi, Frost, Adaani, Jackson, Robert E., Wong, Stephen T. C.

“…Healthcare regulatory agencies have mandated a reduction in 30-day hospital readmission rates and have targeted COPD as a major contributor to 30-day…”
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Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces by Xia, Zheng, Wu, Ling-Yun, Zhou, Xiaobo, Wong, Stephen T C

“…Predicting drug-protein interactions from heterogeneous biological data sources is a key step for in silico drug discovery. The difficulty of this prediction…”
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Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease by Faridar, Alireza, Vasquez, Matthew, Thome, Aaron D, Yin, Zheng, Xuan, Hui, Wang, Jing Hong, Wen, Shixiang, Li, Xuping, Thonhoff, Jason R, Zhao, Weihua, Zhao, Hong, Beers, David R, Wong, Stephen T C, Masdeu, Joseph C, Appel, Stanley H

“…Regulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating adaptive immune reactions…”
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A Novel Method of Transcriptional Response Analysis to Facilitate Drug Repositioning for Cancer Therapy by GUANGXU JIN, CHANGHE FU, HONG ZHAO, KEMI CUI, JENNY CHANG, WONG, Stephen T. C

“…Little research has been done to address the huge opportunities that may exist to reposition existing approved or generic drugs for alternate uses in cancer…”
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Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome by Cheng, Robert Y. S., Ridnour, Lisa A., Wink, Adelaide L., Gonzalez, Ana L., Femino, Elise L., Rittscher, Helene, Somasundaram, Veena, Heinz, William F., Coutinho, Leandro, Rangel, M. Cristina, Edmondson, Elijah F., Butcher, Donna, Kinders, Robert J., Li, Xiaoxian, Wong, Stephen T. C., McVicar, Daniel W., Anderson, Stephen K., Pore, Milind, Hewitt, Stephen M., Billiar, Timothy R., Glynn, Sharon A., Chang, Jenny C., Lockett, Stephen J., Ambs, Stefan, Wink, David A.

“…A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of…”
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Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders by Li, Hai, Xue, Zhong, Ellmore, Timothy M., Frye, Richard E., Wong, Stephen T.C.

“…Neuroimaging has uncovered both long‐range and short‐range connectivity abnormalities in the brains of individuals with autism spectrum disorders (ASD)…”
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Multiple Nuclei Tracking Using Integer Programming for Quantitative Cancer Cell Cycle Analysis by Fuhai Li, Xiaobo Zhou, Jinwen Ma, Wong, S.

“…Automated cell segmentation and tracking are critical for quantitative analysis of cell cycle behavior using time-lapse fluorescence microscopy. However, the…”
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Involvement of epidermal growth factor receptor overexpression in the promotion of breast cancer brain metastasis by Nie, Fang, Yang, Jian, Wen, Song, An, Yan‐Li, Ding, Jie, Ju, Sheng‐Hong, Zhao, Zhen, Chen, Hua‐Jun, Peng, Xin‐Gui, Wong, Stephen T. C., Zhao, Hong, Teng, Gao‐Jun

“…BACKGROUND: Brain‐metastatic breast cancer (BMBC) is increasing and poses a severe clinical problem because of the lack of effective treatments and because the…”
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Novel Modeling of Cancer Cell Signaling Pathways Enables Systematic Drug Repositioning for Distinct Breast Cancer Metastases by HONG ZHAO, GUANGXU JIN, CHANG, Jenny, WONG, Stephen T. C, KEMI CUI, DING REN, TIMOTHY LIU, PEIKAI CHEN, SOLOMON WONG, FUHAI LI, YUBO FAN, RODRIGUEZ, Angel

“…A new type of signaling network element, called cancer signaling bridges (CSB), has been shown to have the potential for systematic and fast-tracked drug…”
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Novel cell segmentation and online SVM for cell cycle phase identification in automated microscopy by Wang, Meng, Zhou, Xiaobo, Li, Fuhai, Huckins, Jeremy, King, Randall W., Wong, Stephen T.C.

“…Motivation: Automated identification of cell cycle phases captured via fluorescent microscopy is very important for understanding cell cycle and for drug…”
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The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models by Zhao, Hong, Cui, Kemi, Nie, Fang, Wang, Lulu, Brandl, Miriam B., Jin, Guangxu, Li, Fuhai, Mao, Yong, Xue, Zhong, Rodriguez, Angel, Chang, Jenny, Wong, Stephen T. C.

“…mTOR inhibitor rapamycin and its analogs are lipophilic, demonstrate blood–brain barrier penetration, and have shown promising antitumor effects in several…”
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The radiomic-clinical model using the SHAP method for assessing the treatment response of whole-brain radiotherapy: a multicentric study by Wang, Yixin, Lang, Jinwei, Zuo, Joey Zhaoyu, Dong, Yaqin, Hu, Zongtao, Xu, Xiuli, Zhang, Yongkang, Wang, Qinjie, Yang, Lizhuang, Wong, Stephen T. C., Wang, Hongzhi, Li, Hai

“…Objective To develop and validate a pretreatment magnetic resonance imaging (MRI)–based radiomic-clinical model to assess the treatment response of whole-brain…”
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Beyond Primary HER2 Expression: Trastuzumab Deruxtecan's Efficacy in Brain Metastasis by Das, Glori, Wong, Stephen T C, Zhao, Hong

“…This commentary focuses on the DESTINY-Breast12 study, published in Nature Medicine on 13 September 2024, which evaluates the efficacy of Trastuzumab…”
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Big Data for Health by Andreu-Perez, Javier, Poon, Carmen C. Y., Merrifield, Robert D., Wong, Stephen T. C., Yang, Guang-Zhong

“…This paper provides an overview of recent developments in big data in the context of biomedical and health informatics. It outlines the key characteristics of…”
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An Automatic and Robust Algorithm of Reestablishment of Digital Dental Occlusion by Yu-Bing Chang, Xia, J J, Gateno, J, Zixiang Xiong, Xiaobo Zhou, Wong, S T C

“…In the field of craniomaxillofacial (CMF) surgery, surgical planning can be performed on composite 3-D models that are generated by merging a computerized…”
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