Search Results - "Wong, So"

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes by Rozema, David B, Lewis, David L, Wakefield, Darren H, Wong, So C, Klein, Jason J, Roesch, Paula L, Bertin, Stephanie L, Reppen, Tom W, Chu, Qili, Blokhin, Andrei V, Hagstrom, James E, Wolff, Jon A

“…Achieving efficient in vivo delivery of siRNA to the appropriate target cell would be a major advance in the use of RNAi in gene function studies and as a…”
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Immune checkpoint inhibitor–associated capillary leak syndrome: A systematic review and a worldwide pharmacovigilance study by Wong So, Jonathan, Bouibede, Fatma, Jonville‐Béra, Annie‐Pierre, Maillot, François, Barbier, François, Largeau, Bérenger

“…Background Although a few case reports have shown that immune checkpoint inhibitors (ICIs) are potential inducers of capillary leak syndrome (CLS), an…”
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HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans by Ma, Yuanqing, Joyce, Allison, Brandenburg, Olivia, Saatchi, Faeze, Stevens, Christina, Toffessi Tcheuyap, Vanina, Christie, Alana, Do, Quyen N, Fatunde, Oluwatomilade, Macchiaroli, Alyssa, Wong, So C, Woolford, Layton, Yousuf, Qurratulain, Miyata, Jeffrey, Carrillo, Deyssy, Onabolu, Oreoluwa, McKenzie, Tiffani, Mishra, Akhilesh, Hardy, Tanner, He, Wei, Li, Daniel, Ivanishev, Alexander, Zhang, Qing, Pedrosa, Ivan, Kapur, Payal, Schluep, Thomas, Kanner, Steven B, Hamilton, James, Brugarolas, James

“…HIF2α is a key driver of kidney cancer. Using a belzutifan analogue (PT2399), we previously showed in tumorgrafts (TG) that ∼50% of clear cell renal cell…”
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Unexpected discovery of Trypanosoma brucei gambiense on CSF in a western country: About a case by Francois, Lou-Ann, Bret, Laurent, Wong So, Jonathan, Gubavu, Camelia, Touafek, Feriel, Vinsonneau, Morgane, Kochbati, Khaoula, Avettand-Fenoel, Véronique, Guillaume, Clemence, Carbonnelle, Etienne, Guinard, Jérôme, Mchantaf, Gilbert

“…[...]she reported a weight loss of 20 Kg, asthenia, and psychiatric symptoms such as uncommon severe anxiety, personality changes with irritability, and…”
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Targeted in vivo delivery of siRNA and an endosome-releasing agent to hepatocytes by Sebestyén, Magdolna G, Wong, So C, Trubetskoy, Vladimir, Lewis, David L, Wooddell, Christine I

“…The discoveries of RNA interference (RNAi) and short interfering RNAs (siRNAs) have provided the opportunity to treat diseases in a fundamentally new way: by…”
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Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi[S] by Butler, Andrew A., Graham, James L., Stanhope, Kimber L., Wong, So, King, Sarah, Bremer, Andrew A., Krauss, Ronald M., Hamilton, James, Havel, Peter J.

“…Angiopoietin-like protein 3 (ANGPTL3) inhibits lipid clearance and is a promising target for managing cardiovascular disease. Here we investigated the effects…”
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Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or ApoC3 RNA interference[S] by Butler, Andrew A., Price, Candice A., Graham, James L., Stanhope, Kimber L., King, Sarah, Hung, Yu-Han, Sethupathy, Praveen, Wong, So, Hamilton, James, Krauss, Ronald M., Bremer, Andrew A., Havel, Peter J.

“…Dyslipidemia and insulin resistance are significant adverse outcomes of consuming high-sugar diets. Conversely, dietary fish oil (FO) reduces plasma lipids…”
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Effects of healthcare system transformations spurred by the COVID-19 pandemic on management of stroke and STEMI: a registry-based cohort study in France by Lesaine, Emilie, Francis-Oliviero, Florence, Domecq, Sandrine, Bijon, Marine, Cetran, Laura, Coste, Pierre, Lhuaire, Quentin, Miganeh-Hadi, Sahal, Pradeau, Catherine, Rouanet, François, Sevin, Floriane, Sibon, Igor, Saillour-Glenisson, Florence, Faucheux, JM, Leca Radu, E, Seignolles, G, Chazalon, C, Dan, M, Lucas, L, Péron, J, Wong So, L, Martinez, M, Nocon, C, Hostyn, V, Papin, J, Bordier, P, Casenave, P, Maillard, L, Ondze, B, Argacha, I, Tidahy, E, Ferraton, L, Mostefai, Y, Demasles, S, Hubrecht, R, Bakpa, D, Bartou, C, Bannier, S, Bernady, P, Ellie, E, Higue, D, Marnat, G, Berge, J, Goze-Dupuy, C, Lavocat, H, Senis, F, Delonglee, V, Darraillans, D, Mokni, T, Bataille, B, Lorendeau, JP, Eclancher, A, Trogoff, B, Chartroule, V, Touchard, P, Leyral, H, Ngounou Fogue, C, Scouarnec, C, Orcival, F, Goulois, N, Wong-So, L, Heydel, V, Tahon, B, Py, E, Bidian, S, Fabre, J, Cherhabil, N, Baha, L, Fort, PA, Maisonnave, V, Verhoeven, L, Claveries, P, Ansart, E, Lefevre, B, Liepa, MP, Lacrouts, M, Coustere, JB, Fournier, P, Jarnier, P, Delarche, N, Banos, JL, Marque, N, Karsenty, B, Perron, JM, Leymarie, JL, Hassan, A, Casteigt, F, Larnaudie, B, Combes, X, Laplace, G

“…ObjectiveTo assess the impact of changes in use of care and implementation of hospital reorganisations spurred by the COVID-19 pandemic (first wave) on the…”
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HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma by Wong, So C, Cheng, Weijun, Hamilton, Holly, Nicholas, Anthony L, Wakefield, Darren H, Almeida, Aaron, Blokhin, Andrei V, Carlson, Jeffrey, Neal, Zane C, Subbotin, Vladimir, Zhang, Guofeng, Hegge, Julia, Bertin, Stephanie, Trubetskoy, Vladimir S, Rozema, David B, Lewis, David L, Kanner, Steven B

“…Targeted therapy against VEGF and mTOR pathways has been established as the standard-of-care for metastatic clear cell renal cell carcinoma (ccRCC); however,…”
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Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association? by Wong So, Jonathan, Largeau, Bérenger, Beau-Salinas, Frédérique, Ehrmann, Stephan, Magni, Christophe, Meunier, Jérôme

“…Introduction: Pazopanib is an oral protein kinase inhibitor (PKI) that targets vascular endothelial growth factor (VEGF) receptors, fibroblastic growth factor…”
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Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo by Wong, So C, Klein, Jason J, Hamilton, Holly L, Chu, Qili, Frey, Christina L, Trubetskoy, Vladimir S, Hegge, Julia, Wakefield, Darren, Rozema, David B, Lewis, David L

“…Effective in vivo delivery of small interfering (siRNA) has been a major obstacle in the development of RNA interference therapeutics. One of the first…”
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Protease-triggered siRNA delivery vehicles by Rozema, David B, Blokhin, Andrei V, Wakefield, Darren H, Benson, Jonathan D, Carlson, Jeffrey C, Klein, Jason J, Almeida, Lauren J, Nicholas, Anthony L, Hamilton, Holly L, Chu, Qili, Hegge, Julia O, Wong, So C, Trubetskoy, Vladimir S, Hagen, Collin M, Kitas, Eric, Wolff, Jon A, Lewis, David L

“…The safe and efficacious delivery of membrane impermeable therapeutics requires cytoplasmic access without the toxicity of nonspecific cytoplasmic membrane…”
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Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules by Sebestyén, Magdolna G., Budker, Vladimir G., Budker, Tatiana, Subbotin, Vladimir M., Zhang, Guofeng, Monahan, Sean D., Lewis, David L., Wong, So C., Hagstrom, James E., Wolff, Jon A.

“…Background The hydrodynamic tail vein (HTV) injection of naked plasmid DNA is a simple yet effective in vivo gene delivery method into hepatocytes. It is…”
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Abstract 4775: Optimizing the potency and dosing design for ARO-HIF2: An RNAi therapeutic for clear cell renal cell carcinoma by Wong, So C., Nicholas, Anthony, Carlson, Jeff, Shu, Dongxu, Liu, Che, Chu, Rui, Frankiewicz, Amanda, Hamilton, Holly, Schienebeck, Casi, Andersen, Aaron, Fowler-Watters, Matthew, Bertin, Stephanie, Li, Xiaokai, Chen, Bo, Schumacher, Josh, Hegge, Julia, Given, Bruce, Li, Zhen

“…Abstract Background: Clear cell renal cell carcinoma (ccRCC) frequently involves the inactivation of the von Hippel-Lindau (VHL) tumor suppressor. Loss of VHL…”
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Hydration and nutritional status in patients on home‐dialysis—A single centre study by Li, Janet S.C., Chan, John Y.H., Tai, Mandy M.Y., Wong, So M., Pang, S.M., Lam, Fanny Y.F., Chu, Carmen H.M., Ching, Chris S.Y., Wong, Joseph H.S., Chak, W.L.

“…SUMMARY Background Over‐hydration (OH) and malnutrition are prevalent among patients on dialysis therapy. The prevalence of OH and malnutrition as well as the…”
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Isolation of Human cDNAs That Restore Methotrexate Sensitivity and Reduced Folate Carrier Activity in Methotrexate Transport-defective Chinese Hamster Ovary Cells by Wong, So C., Proefke, Susan A., Bhushan, Alok, Matherly, Larry H.

“…This report describes the isolation, nucleotide sequencing, and functional expression of human cDNAs that restore reduced folate carrier activity in…”
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Critical Literacy Practices Within Problem-Based Learning Projects in Science by Wong, Suzanna So Har, Kim, Mijung, Jin, Qingna

“…Digital technologies are part of many children’s everyday lives. They use them for entertainment, information seeking and connecting with friends on social…”
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In vivo selection and validation of liver-specific ligands using a new T7 phage peptide display system by Ludtke, James J, Sololoff, Alex V, Wong, So C, Zhang, Guofeng, Wolff, Jon A

“…In vivo phage display is a powerful source of new peptide ligands for specific organ targeting by drugs and gene therapy vectors. Since the introduction of…”
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Hepatocyte Targeting of Nucleic Acid Complexes and Liposomes by a T7 Phage p17 Peptide by Wong, So C, Wakefield, Darren, Klein, Jason, Monahan, Sean D, Rozema, David B, Lewis, David L, Higgs, Lori, Ludtke, James, Sokoloff, Alex V, Wolff, Jon A

“…A critical step for liver-directed gene therapy is the selective targeting of nucleic acids to hepatocytes. We have previously discovered that the proximal…”
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Mobile Digital Devices and Preschoolers’ Home Multiliteracy Practices by Wong, Suzanna So-har

“…The increased use of digital devices such as touchscreen tablets in the home for work, communication, entertainment, and information searching makes them…”
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