Search Results - "Wong, S. M."

Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung by Gawronski, Jeffrey D, Wong, Sandy M.S, Giannoukos, Georgia, Ward, Doyle V, Akerley, Brian J

“…Rapid genome-wide identification of genes required for infection would expedite studies of bacterial pathogens. We developed genome-scale "negative selection"…”
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High Morbidity and Mortality in Adults Hospitalized for Respiratory Syncytial Virus Infections by Lee, N., Lui, G. C. Y., Wong, K. T., Li, T. C. M., Tse, E. C. M., Chan, J. Y. C., Yu, J., Wong, S. S. M., Choi, K. W., Wong, R. Y. K., Ngai, K. L. K., Hui, D. S. C., Chan, P. K. S.

“…Background. Better understanding of complications and outcomes of adults hospitalized with respiratory syncytial virus (RSV) infection is necessary. Methods. A…”
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Impact of land surface heterogeneity on urban heat island circulation and sea‐land breeze circulation in Hong Kong by Wang, Y., Di Sabatino, S., Martilli, A., Li, Y., Wong, M. S., Gutiérrez, E., Chan, P. W.

“…Hong Kong is one of the most high‐rise and highly compact cities in the world. The urban land surface is highly heterogeneous, which creates low‐level…”
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Meta‐analysis on night shift work and risk of metabolic syndrome by Wang, F, Zhang, L, Zhang, Y, Zhang, B, He, Y, Xie, S, Li, M, Miao, X, Chan, E. Y. Y, Tang, J. L, Wong, M. C. S, Li, Z, Yu, I. T. S, Tse, L. A

“…This study aims to quantitatively summarize the association between night shift work and the risk of metabolic syndrome (MetS), with special reference to the…”
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Reliability and Validity Study of Clinical Ultrasound Imaging on Lateral Curvature of Adolescent Idiopathic Scoliosis by Wang, Q, Li, M, Lou, Edmond H M, Wong, M S

“…Non-ionizing radiation imaging assessment has been advocated for the patients with adolescent idiopathic scoliosis (AIS). As one of the radiation-free methods,…”
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A novel electronic health record-based, machine-learning model to predict severe hypoglycemia leading to hospitalizations in older adults with diabetes: A territory-wide cohort and modeling study by Shi, Mai, Yang, Aimin, Lau, Eric S H, Luk, Andrea O Y, Ma, Ronald C W, Kong, Alice P S, Wong, Raymond S M, Chan, Jones C M, Chan, Juliana C N, Chow, Elaine

“…Older adults with diabetes are at high risk of severe hypoglycemia (SH). Many machine-learning (ML) models predict short-term hypoglycemia are not specific for…”
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Uncovering the magnitude of African pangolin poaching with extensive nanopore DNA genotyping of seized scales by Yeo, Darren, Chan, Amy H. J., Hiong, Kum Chew, Ong, Jasmine, Ng, Jun Yuan, Lim, Jie Min, Zhang, Wendy, Lim, Sara R., Fernandez, Charlene J., Wong, Anna M‐S., Lee, Benjamin P. Y‐H., Khoo, Max D. Y., Cheng, Thaddaeus X. W., Lim, Bryan T. M., Yeo, Hazelina H. T., Tan, Maxine M. Q., Sng, Wendy B. G., Adam, Shaun S., Ang, Wee Foong, How, Choon Beng, Xie, Renhui, Wasser, Samuel K., Finch, Kristen N., Loo, Adrian H. B., Yap, Him Hoo, Leong, Chee Chiew, Er, Kenneth B. H.

“…Trade in pangolins is illegal, and yet tons of their scales and products are seized at various ports. These large seizures are challenging to process and…”
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Renin inhibitor aliskiren exerts beneficial effect on trabecular bone by regulating skeletal renin-angiotensin system and kallikrein-kinin system in ovariectomized mice by Zhang, Y., Wang, L., Song, Y., Zhao, X., Wong, M. S., Zhang, W.

“…Summary The skeletal renin-angiotensin system contributes to the development of osteoporosis. The renin inhibitor aliskiren exhibited beneficial effects on…”
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PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK–ERK signaling by Mzoughi, Slim, Zhang, Jingxian, Hequet, Delphine, Teo, Shun Xie, Fang, Haitong, Xing, Qiao Rui, Bezzi, Marco, Seah, Michelle Kay Yi, Ong, Sheena L M, Shin, Eun Myoung, Wollmann, Heike, Wong, Esther S M, Al-Haddawi, Muthafar, Stewart, Colin L, Tergaonkar, Vinay, Loh, Yuin-Han, Dunn, N Ray, Messerschmidt, Daniel M, Guccione, Ernesto

“…Ernesto Guccione and colleagues report that the transcription factor PRDM15 regulates naive pluripotency in mouse embryos and embryonic stem cells and in…”
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Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria by Chojnowski, Alexandre, Ong, Peh Fern, Wong, Esther S M, Lim, John S Y, Mutalif, Rafidah A, Navasankari, Raju, Dutta, Bamaprasad, Yang, Henry, Liow, Yi Y, Sze, Siu K, Boudier, Thomas, Wright, Graham D, Colman, Alan, Burke, Brian, Stewart, Colin L, Dreesen, Oliver

“…Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin…”
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Palliative Liver Radiotherapy (RT) for Symptomatic Hepatocellular Carcinoma (HCC) by Yeung, Cynthia S. Y., Chiang, C. L., Wong, Natalie S. M., Ha, S. K., Tsang, K. S., Ho, Connie H. M., Wang, B., Lee, Venus W. Y., Chan, Mark K. H., Lee, Francis A. S.

“…This study aims at evaluating the symptom response, response duration, and toxicity of single dose palliative liver radiotherapy (RT) for symptomatic HCC…”
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Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis by Thelen, Melanie, Damme, Markus, Daμμe, Markus, Schweizer, Michaela, Hagel, Christian, Wong, Andrew M S, Cooper, Jonathan D, Braulke, Thomas, Galliciotti, Giovanna

“…Variant late-infantile neuronal ceroid lipofuscinosis, a fatal lysosomal storage disorder accompanied by regional atrophy and pronounced neuron loss in the…”
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SPINK2 Protein Expression Is an Independent Adverse Prognostic Marker in AML and Is Potentially Implicated in the Regulation of Ferroptosis and Immune Response by Pitts, Herbert Augustus, Cheng, Chi-Keung, Cheung, Joyce Sin, Sun, Murphy Ka-Hei, Yung, Yuk-Lin, Chan, Hoi-Yun, Wong, Raymond S M, Yip, Sze-Fai, Lau, Ka-Ngai, Wong, Wai Shan, Raghupathy, Radha, Chan, Natalie P H, Ng, Margaret H L

“…There is an urgent need for the identification as well as clinicopathological and functional characterization of potent prognostic biomarkers and therapeutic…”
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Scaling Pharmacodynamics from Rats to Humans to Support Erythropoietin and Romiplostim Combination Therapy to Treat Erythropoietin-Resistant Anemia by Fan, Xiaoqing, Krzyzanski, Wojciech, Liu, Dongyang, Wong, Raymond S M, Yan, Xiaoyu

“…Recombinant human erythropoietin (rHuEPO) is one of the most effective drugs for the treatment of anemia in patients with chronic kidney disease. However,…”
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Cost-effectiveness of dabigatran versus genotype-guided management of warfarin therapy for stroke prevention in patients with atrial fibrillation by You, Joyce H S, Tsui, Kia K N, Wong, Raymond S M, Cheng, Gergory

“…Dabigatran is associated with lower rate of stroke comparing to warfarin when anticoagulation control is sub-optimal. Genotype-guided warfarin dosing and…”
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Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles by Wong, S.M., Kellaway, I.W., Murdan, S.

“…The slow dissolution rate exhibited by poorly water-soluble drugs is a major challenge in the drug development process. Following oral administration, drugs…”
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Predicting probable Alzheimer's disease using linguistic deficits and biomarkers by Orimaye, Sylvester O, Wong, Jojo S-M, Golden, Karen J, Wong, Chee P, Soyiri, Ireneous N

“…The manual diagnosis of neurodegenerative disorders such as Alzheimer's disease (AD) and related Dementias has been a challenge. Currently, these disorders are…”
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Detection of a novel Babesia sp. in Amblyomma javanense, an ectoparasite of Sunda pangolins by Chong, Stacy Q. Y, Yeo, Darren, Aidil, Nur Insyirah, Ong, Jasmine L. Y, Chan, Amy H. J, Fernandez, Charlene Judith, Lim, Bryan T. M, Khoo, Max D. Y, Wong, Anna M. S, Chang, Siow Foong, Yap, Him Hoo

“…Babesia is a protozoal, tick-borne parasite that can cause life-threatening disease in humans, wildlife and domestic animals worldwide. However, in Southeast…”
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A Domino Diels–Alder Approach toward the Tetracyclic Nicandrenone Framework by Mackay, Emily G, Nörret, Marck, Wong, Leon S.-M, Louis, Ignace, Lawrence, Andrew L, Willis, Anthony C, Sherburn, Michael S

“…The tetracarbocyclic framework of the nicandrenone natural products is formed in one step from a linear precursor via a domino intramolecular…”
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Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments by Sun, Kun, Jiang, Peiyong, Chan, K. C. Allen, Wong, John, Cheng, Yvonne K. Y., Liang, Raymond H. S., Chan, Wai-kong, Ma, Edmond S. K., Chan, Stephen L., Cheng, Suk Hang, Chan, Rebecca W. Y., Tong, Yu K., Ng, Simon S. M., Wong, Raymond S. M., Hui, David S. C., Leung, Tse Ngong, Leung, Tak Y., Lai, Paul B. S., Chiu, Rossa W. K., Lo, Yuk Ming Dennis

“…Plasma consists of DNA released from multiple tissues within the body. Using genome-wide bisulfite sequencing of plasma DNA and deconvolution of the sequencing…”
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