Search Results - "Wong, S. L."

High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies by Cao, Jicong, Novoa, Eva Maria, Zhang, Zhizhuo, Chen, William C. W., Liu, Dianbo, Choi, Gigi C. G., Wong, Alan S. L., Wehrspaun, Claudia, Kellis, Manolis, Lu, Timothy K.

“…Despite significant clinical progress in cell and gene therapies, maximizing protein expression in order to enhance potency remains a major technical…”
Get full text

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM by Wong, Alan S. L., Choi, Gigi C. G., Cui, Cheryl H., Pregernig, Gabriela, Milani, Pamela, Adam, Miriam, Perli, Samuel D., Kazer, Samuel W., Gaillard, Aleth, Hermann, Mario, Shalek, Alex K., Fraenkel, Ernest, Lu, Timothy K.

“…The orchestrated action of genes controls complex biological phenotypes, yet the systematic discovery of gene and drug combinations that modulate these…”
Get full text

Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy by HOLMES, L. B, BALDWIN, E. J, SMITH, C. R, HABECKER, E, GLASSMAN, L, WONG, S. L, WYSZYNSKI, D. F

“…Pregnancy registries for women taking anticonvulsant drugs have been developed to determine more efficiently the fetal risks of each drug. A total of 722…”
Get full text

Nanozymes for Environmental Pollutant Monitoring and Remediation by Wong, Elicia L S, Vuong, Khuong Q, Chow, Edith

“…Nanozymes are advanced nanomaterials which mimic natural enzymes by exhibiting enzyme-like properties. As nanozymes offer better structural stability over…”
Get full text

Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities by Thean, Dawn G. L., Chu, Hoi Yee, Fong, John H. C., Chan, Becky K. C., Zhou, Peng, Kwok, Cynthia C. S., Chan, Yee Man, Mak, Silvia Y. L., Choi, Gigi C. G., Ho, Joshua W. K., Zheng, Zongli, Wong, Alan S. L.

“…The genome-editing Cas9 protein uses multiple amino-acid residues to bind the target DNA. Considering only the residues in proximity to the target DNA as…”
Get full text

Influence of exfoliated graphite nanoplatelets on the flammability and thermal properties of polyethylene terephthalate/polypropylene nanocomposites by INUWA, I. M, HASSAN, Azman, WANG, De-Yi, SAMSUDIN, S. A, MOHAMAD HAAFIZ, M. K, WONG, S. L, JAWAID, M

“…Nanocomposites based polyethylene terephthalate (PET)/polypropylene (PP) (70/30 wt%) blends and exfoliated graphite nanoplatelets (GNP) as reinforcing fillers…”
Get full text

Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease by Wong, Alan S. L., Lee, Rebecca H. K., Cheung, Anthony Y., Yeung, Patrick K., Chung, Sookja K., Cheung, Zelda H., Ip, Nancy Y.

“…Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is increasingly implicated in various neurodegenerative diseases. Deregulated Cdk5 activity…”
Get full text

Charge Transfer through DNA: A Selective Electrochemical DNA Biosensor by Wong, Elicia L. S, Gooding, J. Justin

“…The charge-transfer properties of DNA duplexes are exploited to produce a fast, simple, sensitive, and selective DNA biosensor by exposing the DNA recognition…”
Get full text

DNA Recognition Interfaces:  The Influence of Interfacial Design on the Efficiency and Kinetics of Hybridization by Wong, Elicia L. S, Chow, Edith, Gooding, J. Justin

“…The effect of the surface chemistry of DNA recognition interfaces on DNA hybridization at a gold surface was investigated using both electrochemistry and the…”
Get full text

Fine particulate matter from urban ambient and wildfire sources from California’s San Joaquin Valley initiate differential inflammatory, oxidative stress, and xenobiotic responses in human bronchial epithelial cells by Nakayama Wong, L.S., Aung, H.H., Lamé, M.W., Wegesser, T.C., Wilson, D.W.

“…► APM induce CCL20. ► APM more proinflammatory than WF. ► WF elicit PAH and ROS responses. Environmental particulate matter (PM) exposure has been correlated…”
Get full text

Retrospective Planning Study of Patients with Superior Sulcus Tumours Comparing Pencil Beam Scanning Protons to Volumetric-Modulated Arc Therapy by Wong, S.-L., Alshaikhi, J., Grimes, H., Amos, R.A., Poynter, A., Rompokos, V., Gulliford, S., Royle, G., Liao, Z., Sharma, R.A., Mendes, R.

“…Twenty per cent of patients with non-small cell lung cancer present with stage III locally advanced disease. Precision radiotherapy with pencil beam scanning…”
Get full text

Telomere length loss due to smoking and metabolic traits by Huzen, J., Wong, L. S. M., Veldhuisen, D. J., Samani, N. J., Zwinderman, A. H., Codd, V., Cawthon, R. M., Benus, G. F. J. D., Horst, I. C.C., Navis, G., Bakker, S. J. L., Gansevoort, R. T., Jong, P. E., Hillege, H. L., Gilst, W. H., Boer, R. A., Harst, P.

“…Objectives Human age‐dependent telomere attrition and telomere shortening are associated with several age‐associated diseases and poorer overall survival. The…”
Get full text

Healthcare professionals' and policy makers' views on implementing a clinical practice guideline of hypertension management: a qualitative study by Lee, Ping Yein, Liew, Su May, Abdullah, Adina, Abdullah, Nurdiana, Ng, Chirk Jenn, Hanafi, Nik Sherina, Chia, Yook Chin, Lai, Pauline S M, Wong, Stalia S L, Khoo, Ee Ming

“…Most studies have reported barriers to guideline usage mainly from doctors' perspective; few have reported the perspective of other stakeholders. This study…”
Get full text

Daylighting and energy implications due to shading effects from nearby buildings by Li, Danny H.W., Wong, S.L.

“…Daylighting has long been recognized as a potential energy-efficient design strategy for buildings. Natural light can help reduce the electrical demand and the…”
Get full text

Lighting and energy performance for an office using high frequency dimming controls by Li, Danny H.W., Lam, Tony N.T., Wong, S.L.

“…Artificial lighting is one of the major electricity consuming items in many non-domestic buildings. Recently, there has been an increasing interest in…”
Get full text

Photosynthetic Microorganisms Consortium as Bioindicators for Heavy Metals by Khishamuddin, N. A., Wong, L. S., Chai, M. K., Subramaniam, G.

“…Heavy metals that are discharged through industrial and agricultural activities cause contamination, especially to the water sources, and bring about negative…”
Get full text

An analysis of future building energy use in subtropical Hong Kong by Lam, Joseph C., Wan, Kevin K.W., Lam, Tony N.T., Wong, S.L.

“…Principal component analysis of prevailing weather conditions in subtropical Hong Kong was conducted, and a new climatic index Z (as a function of the dry-bulb…”
Get full text

Impact of climate change on residential building envelope cooling loads in subtropical climates by Wong, S.L., Wan, Kevin K.W., Li, Danny H.W., Lam, Joseph C.

“…Future trends of cooling load due to heat gain through the building envelopes in the residential sector in subtropical Hong Kong under different emissions…”
Get full text

Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document by Lygidakis, N. A., Garot, E., Somani, C., Taylor, G. D., Rouas, P., Wong, F. S. L.

“…Aim To update the existing European Academy of Paediatric Dentistry (EAPD) 2010 policy document on the ‘Best Clinical Practice guidance for clinicians dealing…”
Get full text

Mortality and Neurological Outcomes in Out-of-Hospital Cardiac Arrest Patients With and Without Targeted Temperature Management in a Multiethnic Asian Population by Tay, Wan Jing, Li, Huihua, Ho, Andrew Fw, Sia, Ching Hui, Kwek, Georgina Gj, Pothiawala, Sohil, Shahidah, Nur, Tan, Kenneth Bk, Wong, Aaron Sl, Sewa, Duu Wen, Lim, Eric Ts, Chin, Chee Tang, Ong, Marcus Eh

“…The use of targeted temperature management (TTM) is increasing although adoption is still variable. We describe our 6-year experience and compare the mortality…”
Get more information