Search Results - "Wong, Nelson K. Y"

Nontransformed and Cancer Cells Can Utilize Different Endocytic Pathways To Internalize Dendritic Nanoparticle Variants: Implications on Nanocarrier Design by Wong, Nelson K. Y, Shenoi, Rajesh A, Abbina, Srinivas, Chafeeva, Irina, Kizhakkedathu, Jayachandran N, Khan, Mohamed K

“…Three hyperbranched polyglycerol nanoparticle (HPG NP) variants were synthesized and fluorescently labeled for the study of their cellular interactions. The…”
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Ovarian carcinosarcomas: p53 status defines two distinct patterns of oncogenesis and outcomes by Dhillon, Gurdial, Llaurado-Fernandez, Marta, Tessier-Cloutier, Basile, Sy, Keiyan, Bassiouny, Dina, Han, Guangming, Wong, Nelson K Y, McRae, Kathryn, Kinloch, Mary, Pors, Jennifer, Hopkins, Laura, Covens, Allan, Köbel, Martin, Lee, Cheng-Han, Carey, Mark S

“…Ovarian carcinosarcoma (OCS) is a rare and lethal type of ovarian cancer. Despite its incredibly poor prognosis, it has received little research attention. In…”
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Framework of Intrinsic Immune Landscape of Dormant Prostate Cancer by Wong, Nelson K Y, Dong, Xin, Lin, Yen-Yi, Xue, Hui, Wu, Rebecca, Lin, Dong, Collins, Colin, Wang, Yuzhuo

“…Androgen deprivation therapy (ADT) is the standard therapy for men with advanced prostate cancer (PCa). PCa often responds to ADT and enters a dormancy period,…”
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Design Considerations for Developing Hyperbranched Polyglycerol Nanoparticles as Systemic Drug Carriers by Wong, Nelson K Y, Misri, Ripen, Shenoi, Rajesh A, Chafeeva, Irina, Kizhakkedathu, Jayachandran N, Khan, Mohamed K

“…PEGylation is commonly used to increase the plasma residence time of anticancer drug nanocarriers. However, PEGylation may trigger antibody production and lead…”
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CD45 Down-Regulates Lck-Mediated CD44 Signaling and Modulates Actin Rearrangement in T Cells by Wong, Nelson K. Y, Lai, Jacqueline C. Y, Birkenhead, Darlene, Shaw, Andrey S, Johnson, Pauline

“…The tyrosine phosphatase CD45 dephosphorylates the negative regulatory tyrosine of the Src family kinase Lck and plays a positive role in TCR signaling. In…”
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Phenotype prediction from single-cell RNA-seq data using attention-based neural networks by Mao, Yuzhen, Lin, Yen-Yi, Wong, Nelson K Y, Volik, Stanislav, Sar, Funda, Collins, Colin, Ester, Martin

“…Abstract Motivation A patient’s disease phenotype can be driven and determined by specific groups of cells whose marker genes are either unknown or can only be…”
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CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and phosphatidylinositol-3 kinase by Wong, Nelson K.Y., Lai, Jacqueline C.Y., Maeshima, Nina, Johnson, Pauline

“…The proline-rich tyrosine kinase 2, Pyk2, is a focal adhesion related kinase expressed in T cells that is tyrosine phosphorylated and activated by integrin,…”
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Multiomics Characterization of Low-Grade Serous Ovarian Carcinoma Identifies Potential Biomarkers of MEK Inhibitor Sensitivity and Therapeutic Vulnerability by Shrestha, Raunak, Llaurado Fernandez, Marta, Dawson, Amy, Hoenisch, Joshua, Volik, Stanislav, Lin, Yen-Yi, Anderson, Shawn, Kim, Hannah, Haegert, Anne M, Colborne, Shane, Wong, Nelson K Y, McConeghy, Brian, Bell, Robert H, Brahmbhatt, Sonal, Lee, Cheng-Han, DiMattia, Gabriel E, Le Bihan, Stephane, Morin, Gregg B, Collins, Colin C, Carey, Mark S

“…Low-grade serous ovarian carcinoma (LGSOC) is a rare tumor subtype with high case fatality rates in patients with metastatic disease. There is a pressing need…”
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Preclinical 3D model screening reveals digoxin as an effective therapy for a rare and aggressive type of endometrial cancer by Kumar, Pooja Praveen, Smith, DuPreez, Key, James, Dong, He, Ganapathysamy, Ashtalakshmi, Maranda, Vincent, Wong, Nelson K.Y., Fernandez, Marta Llaurado, Kim, Hannah, Zhang, Guihua, Ewanowich, Carol, Hopkins, Laura, Freywald, Andrew, Postovit, Lynne M., Köbel, Martin, Fu, Yangxin, Vizeacoumar, Frederick S., Vizeacoumar, Franco J., Carey, Mark S., Lee, Cheng-Han

“…Dedifferentiated endometrial carcinoma (DDEC) characterized by SWItch/Sucrose Non-Fermentable (SWI/SNF) complex inactivation is a highly aggressive type of…”
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NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition by Llaurado Fernandez, Marta, Hijmans, E Marielle, Gennissen, Annemiek M C, Wong, Nelson K Y, Li, Shang, Wisman, G Bea A, Hamilton, Aleksandra, Hoenisch, Joshua, Dawson, Amy, Lee, Cheng-Han, Bittner, Madison, Kim, Hannah, DiMattia, Gabriel E, Lok, Christianne A R, Lieftink, Cor, Beijersbergen, Roderick L, de Jong, Steven, Carey, Mark S, Bernards, René, Berns, Katrien

“…Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fatality rates in advanced stages due to its chemoresistant…”
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Establishment and validation of preclinical models of SMARCA4-inactivated and ARID1A/ARID1B co-inactivated dedifferentiated endometrial carcinoma by Wong, Nelson K.Y., Fernandez, Marta Llaurado, Kommoss, Felix K.F., Kumar, Pooja Preveen, Kim, Hannah, Liu, Jiahui, Zhang, Guihua, Coatham, Mackenzie, Lin, Yen-Yi, Haegert, Anne M., Volik, Stanislav, Le Bihan, Stephane, Collins, Colin C., Fu, Yangxin, Postovit, Lynne, von Deimling, Andreas, Wu, Rebecca, Xue, Hui, Wang, Yuzhuo, Köbel, Martin, Carey, Mark S., Lee, Cheng-Han

“…Dedifferentiated endometrial cancer (DDEC) is an uncommon and clinically highly aggressive subtype of endometrial cancer characterized by genomic inactivation…”
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Investigation of hydrophobically derivatized hyperbranched polyglycerol with PEGylated shell as a nanocarrier for systemic delivery of chemotherapeutics by Misri, Ripen, PhD, Wong, Nelson K.Y., PhD, Shenoi, Rajesh A., PhD, Lum, Christine M.W., BSc, Chafeeva, Irina, MSc, Toth, Karoly, MD, PhD, Rustum, Youcef, PhD, Kizhakkedathu, Jayachandran N., PhD, Khan, Mohamed K., MD, PhD

“…Abstract We report the synthesis and characterization of a polymeric nanoparticle (NP) based on hyperbranched polyglycerol (HPG) containing a hydrophobic core…”
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Heterogeneity of breast cancer stem cells as evidenced with Notch‐dependent and Notch‐independent populations by Wong, Nelson K. Y., Fuller, Megan, Sung, Sandy, Wong, Fred, Karsan, Aly

“…Studies have suggested the potential importance of Notch signaling to the cancer stem cell population in some tumors, but it is not known whether all cells in…”
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Characterization of Neuronal Intermediate Filament Protein Expression in Cervical Spinal Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis (ALS) by WONG, NELSON K.Y, HE, BEI PING, STRONG, MICHAEL J

“…Because transgenic mice expressing an altered stoichiometry of neurofilament proteins develop a motor neuron degeneration associated with neurofilamentous…”
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Heterogeneity of breast cancer stem cells as evidenced with N otch‐dependent and N otch‐independent populations by Wong, Nelson K. Y., Fuller, Megan, Sung, Sandy, Wong, Fred, Karsan, Aly

“…Abstract Studies have suggested the potential importance of Notch signaling to the cancer stem cell population in some tumors, but it is not known whether all…”
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Differential Function of PTPα and PTPα Y789F in T Cells and Regulation of PTPα Phosphorylation at Tyr-789 by CD45 by Maksumova, Lola, Wang, Yanni, Wong, Nelson K.Y., Le, Hoa T., Pallen, Catherine J., Johnson, Pauline

“…CD45 is a major membrane protein tyrosine phosphatase (PTP) expressed in T cells where it regulates the activity of Lck, a Src family kinase important for T…”
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Abstract 303: Compensatory up-regulation of NEK9 contributes to resistance to PLK1 inhibition in triple-negative breast cancer cells by Wong, Nelson K. Y., Mitchell, Devon, Khan, Mohamed K.

“…Abstract Patients with triple-negative breast cancers (TNBCs) have very poor prognosis in terms of relapse and overall survival. There is currently no targeted…”
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Modeling Androgen Deprivation Therapy-Induced Prostate Cancer Dormancy and Its Clinical Implications by Dong, Xin, Xue, Hui, Mo, Fan, Lin, Yen-Yi, Lin, Dong, Wong, Nelson K Y, Sun, Yingqiang, Wilkinson, Scott, Ku, Anson T, Hao, Jun, Ci, Xinpei, Wu, Rebecca, Haegert, Anne, Silver, Rebecca, Taplin, Mary-Ellen, Balk, Steven P, Alumkal, Joshi J, Sowalsky, Adam G, Gleave, Martin, Collins, Colin, Wang, Yuzhuo

“…Treatment-induced tumor dormancy is a state in cancer progression where residual disease is present but remains asymptomatic. Dormant cancer cells are…”
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Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45 by Maksumova, Lola, Wang, Yanni, Wong, Nelson K Y, Le, Hoa T, Pallen, Catherine J, Johnson, Pauline

“…CD45 is a major membrane protein tyrosine phosphatase (PTP) expressed in T cells where it regulates the activity of Lck, a Src family kinase important for T…”
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Differential Function of PTPα and PTPα Y789F in T Cells and Regulation of PTPα Phosphorylation at Tyr-789 by CD45 by Lola Maksumova, Yanni Wang, Nelson K. Y. Wong, Hoa T. Le, Catherine J. Pallen, Pauline Johnson

“…CD45 is a major membrane protein tyrosine phosphatase (PTP) expressed in T cells where it regulates the activity of Lck, a Src family kinase important for T…”
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