Search Results - "Wong, Lu Min"

Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold by Herberich, Brad, Cao, Guo-Qiang, Chakrabarti, Partha P, Falsey, James R, Pettus, Liping, Rzasa, Robert M, Reed, Anthony B, Reichelt, Andreas, Sham, Kelvin, Thaman, Maya, Wurz, Ryan P, Xu, Shimin, Zhang, Dawei, Hsieh, Faye, Lee, Matthew R, Syed, Rashid, Li, Vivian, Grosfeld, David, Plant, Matthew H, Henkle, Bradley, Sherman, Lisa, Middleton, Scot, Wong, Lu Min, Tasker, Andrew S

“…Investigations into the structure−activity relationships (SAR) of a series of phthalazine-based inhibitors of p38 are described. These efforts originated from…”
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Reversible inhibition of tomato fruit senescence by antisense RNA by Oeller, P.W. (University of California at Berkeley, CA), Min-Wong, L, Taylor, L.P, Pike, D.A, Theologis, A

“…Ethylene controls fruit ripening. Expression of antisense RNA to the rate-limiting enzyme in the biosynthetic pathway of ethylene,…”
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Identification of the auxin-responsive element, AuxRE, in the primary indoleacetic acid-inducible gene, PS-IAA4/5, of pea (Pisum sativum) by Ballas, N, Wong, L M, Theologis, A

“…The plant hormone auxin transcriptionally activates early genes in pea. We have developed a transient assay system using protoplasts of auxin-responsive pea…”
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Signal Transduction and Ligand Specificity of the Human Monocyte Chemoattractant Protein-1 Receptor in Transfected Embryonic Kidney Cells (∗) by Myers, Scott J., Wong, Lu Min, Charo, Israel F.

“…We have examined the ligand specificity and signal transduction pathways of a recently cloned receptor for monocyte chemoattractant protein-1 (MCP-1). In human…”
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NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens by Oh, Julyun, Kirsh, Charles, Hsin, Jing-Ping, Radecki, Kelly C., Zampieri, Alexandre, Manry, Diane, Ando, Yuta, Miller, Sara, Chan, Jamie, McLeod, Ethan, Cunningham, Kathleen M., Wong, Lu Min, Xu, Han, Kamb, Alexander

“…Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E)…”
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Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha by Corral, L G, Haslett, P A, Muller, G W, Chen, R, Wong, L M, Ocampo, C J, Patterson, R T, Stirling, D I, Kaplan, G

“…TNF-alpha mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown thalidomide to be a relatively…”
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DNA elements responsive to auxin by Abel, S, Ballas, N, Wong, L M, Theologis, A

“…Genes induced by the plant hormone auxin are probably involved in the execution of vital cellular functions and developmental processes. Experimental…”
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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor by MAN, Hon-Wah, SCHAFER, Peter, BABUSIS, Darius M, CHEN, Roger, STIRLING, Dave, MULLER, George W, LU MIN WONG, PATTERSON, Rebecca T, CORRAL, Laura G, RAYMON, Heather, BLEASE, Kate, LEISTEN, Jim, SHIRLEY, Michael A, YANG TANG

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Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors by Wu, Bin, Wang, Hui-Ling, Pettus, Liping, Wurz, Ryan P, Doherty, Elizabeth M, Henkle, Bradley, McBride, Helen J, Saris, Christiaan J. M, Wong, Lu Min, Plant, Matthew H, Sherman, Lisa, Lee, Matthew R, Hsieh, Faye, Tasker, Andrew S

“…The p38 mitogen-activated protein kinase (MAPK) plays an important role in the production of proinflammatory cytokines, making it an attractive target for the…”
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3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase by Pettus, Liping H, Xu, Shimin, Cao, Guo-Qiang, Chakrabarti, Partha P, Rzasa, Robert M, Sham, Kelvin, Wurz, Ryan P, Zhang, Dawei, Middleton, Scott, Henkle, Bradley, Plant, Matthew H, Saris, Christiaan J. M, Sherman, Lisa, Wong, Lu Min, Powers, David A, Tudor, Yanyan, Yu, Violeta, Lee, Matthew R, Syed, Rashid, Hsieh, Faye, Tasker, Andrew S

“…The p38 mitogen-activated protein kinase (MAPK) is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a…”
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Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking by Wong, L M, Myers, S J, Tsou, C L, Gosling, J, Arai, H, Charo, I F

“…Two forms of the monocyte chemoattractant protein-1 receptors (the type A monocyte chemoattractant protein 1 (MCP-1) receptor CCR-2A and the type B MCP-1…”
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Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production by Muller, George W., Chen, Roger, Huang, Shaei-Yun, Corral, Laura G., Wong, Lu Min, Patterson, Rebecca T., Chen, Yuxi, Kaplan, Gilla, Stirling, David I.

“…Thalidomide, ( 1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC. Herein we describe the TNF-α inhibitory activity of amino substituted…”
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Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase by Wurz, Ryan P., Pettus, Liping H., Henkle, Bradley, Sherman, Lisa, Plant, Matthew, Miner, Kent, McBride, Helen J., Wong, Lu Min, Saris, Christiaan J.M., Lee, Matthew R., Chmait, Samer, Mohr, Christopher, Hsieh, Faye, Tasker, Andrew S.

“…A novel class of pyrazolopyridazine p38α mitogen-activated protein kinase (MAPK) inhibitors is disclosed. A structure activity relationship (SAR) investigation…”
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Transcriptional regulation of PS-IAA4/5 and PS-IAA6 early gene expression by indoleacetic acid and protein synthesis inhibitors in pea (Pisum sativum) by Koshiba, T, Ballas, N, Wong, L.M, Theologis, A

“…The transcription of two genes, PS-IAA4/5 and PS-IAA6, in pea is induced by indoleacetic acid (IAA) and protein synthesis inhibitors such as cycloheximide…”
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Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase by Wurz, Ryan P., Pettus, Liping H., Xu, Shimin, Henkle, Bradley, Sherman, Lisa, Plant, Matthew, Miner, Kent, McBride, Helen, Wong, Lu Min, Saris, Christiaan J.M., Lee, Matthew R., Chmait, Samer, Mohr, Christopher, Hsieh, Faye, Tasker, Andrew S.

“…A novel class of fused pyrazole-derived inhibitors of p38α mitogen-activated protein kinase (MAPK) is disclosed. These inhibitors were evaluated for their…”
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Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase by Tamayo, Nuria, Liao, Lillian, Goldberg, Martin, Powers, David, Tudor, Yan-Yan, Yu, Violeta, Wong, Lu Min, Henkle, Bradley, Middleton, Scot, Syed, Rashid, Harvey, Timothy, Jang, Graham, Hungate, Randall, Dominguez, Celia

“…Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of…”
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Identification of triazolopyridazinones as potent p38α inhibitors by Herberich, Brad, Jackson, Claire, Wurz, Ryan P., Pettus, Liping H., Sherman, Lisa, Liu, Qiurong, Henkle, Bradley, Saris, Christiaan J.M., Wong, Lu Min, Chmait, Samer, Lee, Matthew R., Mohr, Christopher, Hsieh, Faye, Tasker, Andrew S.

“…Structure–activity relationship (SAR) investigations of a novel class of triazolopyridazinone p38α mitogen activated protein kinase (MAPK) inhibitors are…”
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Two Auxin-Responsive Domains Interact Positively to Induce Expression of the Early Indoleacetic Acid-Inducible Gene PS-IAA4/5 by Ballas, Nurit, Wong, Lu-Min, Ke, Malcolm, Theologis, Athanasios

“…The plant growth hormone indole-3-acetic acid (IAA) transcriptionally activates expression of several genes in plants. We have previously identified a 164-bp…”
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A rational approach to assess off-target reactivity of a dual-signal integrator for T cell therapy by Wang, Xueyin, Wong, Lu Min, McElvain, Michele E., Martire, Sara, Lee, Wen-Hua, Li, Chuck Z., Fisher, Fernando A., Maheshwari, Ruchika L., Wu, Ming Lun, Imun, Maria C., Murad, Rabi, Toledo Warshaviak, Dora, Yin, Jun, Kamb, Alexander, Xu, Han

“…Cell therapy is an emerging therapeutic modality with the power to exploit new cancer targets and potentially achieve positive outcomes for patients with few…”
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Differential activation of the primary auxin response genes, PS‐IAA4/5 and PS‐IAA6, during early plant development by Wong, Lu Min, Abel, Steffen, Shen, Nancy, Foata, Monique, Mall, Yasmeen, Theologis, Athanasios

“…Summary The plant growth hormone auxin typified by indoleacetic acid (IAA) transcriptionally activates early genes in pea, PS‐IAA4/5 and PS‐IAA6, that are…”
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