Search Results - "Wong, Kin Fung"
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Biogenic nanobubbles for effective oxygen delivery and enhanced photodynamic therapy of cancer
Published in Acta biomaterialia (01-05-2020)“…Tumor hypoxia is believed to be a factor limiting successful outcomes of oxygen-consuming cancer therapy, thereby reducing patient survival. A key strategy to…”
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Behavioral and Functional Assessment of Ultrasound Neuromodulation on Caenorhabditis Elegans
Published in IEEE transactions on ultrasonics, ferroelectrics, and frequency control (01-06-2021)“…Ultrasound brain stimulation is a promising modality for probing brain function and treating brain diseases. However, its mechanism is as yet unclear, and in…”
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Nanobubble-actuated ultrasound neuromodulation for selectively shaping behavior in mice
Published in Nature communications (13-03-2024)“…Ultrasound is an acoustic wave which can noninvasively penetrate the skull to deep brain regions, enabling neuromodulation. However, conventional ultrasound’s…”
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Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators
Published in Advanced science (01-11-2021)“…Ultrasound is a promising new modality for non‐invasive neuromodulation. Applied transcranially, it can be focused down to the millimeter or centimeter range…”
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The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
Published in iScience (17-02-2023)“…Microglia are the brain’s resident immune cells, performing surveillance to promote homeostasis and healthy functioning. While microglial chemical signaling is…”
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Photonic Nanojet‐Mediated Optogenetics
Published in Advanced science (01-04-2022)“…Optogenetics has become a widely used technique in neuroscience research, capable of controlling neuronal activity with high spatiotemporal precision and…”
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Metformin accelerates zebrafish heart regeneration by inducing autophagy
Published in npj Regenerative medicine (08-10-2021)“…Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, the underlying mechanism…”
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Photonic Nanojet‐Mediated Optogenetics
Published in Advanced science (01-09-2022)Get full text
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Protocol for the sonogenetic stimulation of mouse brain by non-invasive ultrasound
Published in STAR protocols (18-06-2021)“…Manipulating specific neural activity by targeted ultrasound intervention is a powerful method to gain causal insight into brain functions and treat brain…”
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Surface-modified GVs as nanosized contrast agents for molecular ultrasound imaging of tumor
Published in Biomaterials (01-04-2020)“…Nanobubbles, as a kind of new ultrasound contrast agent (UCAs), have shown promise to penetrate tumor vasculature to allow for targeted imaging. However, their…”
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The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation
Published in Proceedings of the National Academy of Sciences - PNAS (02-05-2023)“…Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the advantages of noninvasiveness, deep penetration, and high…”
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Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound
Published in Cell reports (Cambridge) (18-08-2020)“…Recently developed brain stimulation techniques have significantly advanced our ability to manipulate the brain’s function. However, stimulating specific…”
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Gas-filled protein nanostructures as cavitation nuclei for molecule-specific sonodynamic therapy
Published in Acta biomaterialia (01-12-2021)“…Sonodynamic therapy (SDT) is a promising alternative for cancer therapy, understood to exert cytotoxicity through cavitation and subsequent production of large…”
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Activation of N-Methyl-D-aspartate receptor contributed to the ultrasonic modulation of neurons in vitro
Published in Biochemical and biophysical research communications (08-10-2023)“…Ultrasound stimulation is increasingly used to investigate brain function and treat brain diseases due to its high level of safety and precise spatiotemporal…”
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Modulation of deep neural circuits with sonogenetics
Published in Proceedings of the National Academy of Sciences - PNAS (30-05-2023)“…Noninvasive control of neuronal activity in the deep brain can be illuminating for probing brain function and treating dysfunctions. Here, we present a…”
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Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound
Published in Cell reports (Cambridge) (05-01-2021)Get full text
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Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish
Published in Journal of endocrinology (01-04-2020)“…Sexual differences have been observed in the onset and prognosis of human cardiovascular diseases, but the underlying mechanisms are not clear. Here, we found…”
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