Search Results - "Wong, Keith H.K"

Microfluidic Models of Vascular Functions by Wong, Keith H.K, Chan, Juliana M, Kamm, Roger D, Tien, Joe

“…In vitro studies of vascular physiology have traditionally relied on cultures of endothelial cells, smooth muscle cells, and pericytes grown on…”
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Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels by Price, Gavrielle M, Wong, Keith H.K, Truslow, James G, Leung, Alexander D, Acharya, Chitrangada, Tien, Joe

“…Abstract This work examines how mechanical signals affect the barrier function and stability of engineered human microvessels in microfluidic type I collagen…”
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The role of cyclic AMP in normalizing the function of engineered human blood microvessels in microfluidic collagen gels by Wong, Keith H.K, Truslow, James G, Tien, Joe

“…Abstract Nearly all engineered tissues must eventually be vascularized to survive. To this end, we and others have recently developed methods to synthesize…”
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A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability by Weng, Lindong, Ellett, Felix, Edd, Jon, Wong, Keith H K, Uygun, Korkut, Irimia, Daniel, Stott, Shannon L, Toner, Mehmet

“…Semi- and selective permeability is a fundamentally important characteristic of the cell membrane. Membrane permeability can be determined by monitoring the…”
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Design principles for lymphatic drainage of fluid and solutes from collagen scaffolds by Thompson, Rebecca L., Margolis, Emily A., Ryan, Tyler J., Coisman, Brent J., Price, Gavrielle M., Wong, Keith H. K., Tien, Joe

“…In vivo, tissues are drained of excess fluid and macromolecules by the lymphatic vascular system. How to engineer artificial lymphatics that can provide…”
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Anti-thrombotic strategies for microfluidic blood processing by Wong, Keith H K, Edd, Jon F, Tessier, Shannon N, Moyo, Will D, Mutlu, Baris R, Bookstaver, Lauren D, Miller, Kathleen L, Herrara, Stefan, Stott, Shannon L, Toner, Mehmet

“…The redundant mechanisms involved in blood coagulation are crucial for rapid hemostasis. Yet they also create challenges in blood processing in medical devices…”
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Crosslinking of collagen scaffolds promotes blood and lymphatic vascular stability by Chan, Kelvin L. S., Khankhel, Aimal H., Thompson, Rebecca L., Coisman, Brent J., Wong, Keith H. K., Truslow, James G., Tien, Joe

“…The low stiffness of reconstituted collagen hydrogels has limited their use as scaffolds for engineering implantable tissues. Although chemical crosslinking…”
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Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip by Park, Myoung-Hwan, Reátegui, Eduardo, Li, Wei, Tessier, Shannon N, Wong, Keith H. K, Jensen, Anne E, Thapar, Vishal, Ting, David, Toner, Mehmet, Stott, Shannon L, Hammond, Paula T

“…The detection of rare circulating tumor cells (CTCs) in the blood of cancer patients has the potential to be a powerful and noninvasive method for examining…”
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Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry by Au, Sam H., Edd, Jon, Stoddard, Amy E., Wong, Keith H. K., Fachin, Fabio, Maheswaran, Shyamala, Haber, Daniel A., Stott, Shannon L., Kapur, Ravi, Toner, Mehmet

“…Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although…”
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The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis by Hong, Xin, Roh, Whijae, Sullivan, Ryan J, Wong, Keith H K, Wittner, Ben S, Guo, Hongshan, Dubash, Taronish D, Sade-Feldman, Moshe, Wesley, Benjamin, Horwitz, Elad, Boland, Genevieve M, Marvin, Dieuwke L, Bonesteel, Todd, Lu, Chenyue, Aguet, François, Burr, Risa, Freeman, Samuel S, Parida, Laxmi, Calhoun, Katherine, Jewett, Michelle K, Nieman, Linda T, Hacohen, Nir, Näär, Anders M, Ting, David T, Toner, Mehmet, Stott, Shannon L, Getz, Gad, Maheswaran, Shyamala, Haber, Daniel A

“…Circulating tumor cells (CTC) are shed by cancer into the bloodstream, where a viable subset overcomes oxidative stress to initiate metastasis. We show that…”
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Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology by Cho, Hansang, Seo, Ji Hae, Wong, Keith H. K., Terasaki, Yasukazu, Park, Joseph, Bong, Kiwan, Arai, Ken, Lo, Eng H., Irimia, Daniel

“…Blood–brain barrier (BBB) pathology leads to neurovascular disorders and is an important target for therapies. However, the study of BBB pathology is difficult…”
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Microfluidic isolation of platelet-covered circulating tumor cells by Jiang, Xiaocheng, Wong, Keith H K, Khankhel, Aimal H, Zeinali, Mahnaz, Reategui, Eduardo, Phillips, Matthew J, Luo, Xi, Aceto, Nicola, Fachin, Fabio, Hoang, Anh N, Kim, Wooseok, Jensen, Annie E, Sequist, Lecia V, Maheswaran, Shyamala, Haber, Daniel A, Stott, Shannon L, Toner, Mehmet

“…The interplay between platelets and tumor cells is known to play important roles in metastasis by enhancing tumor cell survival, tumor-vascular interactions,…”
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Neutrophil extracellular traps are increased in cancer patients but does not associate with venous thrombosis by Oklu, Rahmi, Sheth, Rahul A., Wong, Keith H. K., Jahromi, Amin H., Albadawi, Hassan

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Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells by Wong, Keith H. K., Tessier, Shannon N., Miyamoto, David T., Miller, Kathleen L., Bookstaver, Lauren D., Carey, Thomas R., Stannard, Cleo J., Thapar, Vishal, Tai, Eric C., Vo, Kevin D., Emmons, Erin S., Pleskow, Haley M., Sandlin, Rebecca D., Sequist, Lecia V., Ting, David T., Haber, Daniel A., Maheswaran, Shyamala, Stott, Shannon L., Toner, Mehmet

“…Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. Such restrictions limit the translation of…”
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Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis by Frydman, Galit H., Tessier, Shannon N., Wong, Keith H. K., Vanderburg, Charles R., Fox, James G., Toner, Mehmet, Tompkins, Ronald G., Irimia, Daniel

“…Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the…”
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Artificial lymphatic drainage systems for vascularized microfluidic scaffolds by Wong, Keith H. K., Truslow, James G., Khankhel, Aimal H., Chan, Kelvin L. S., Tien, Joe

“…The formation of a stably perfused microvasculature continues to be a major challenge in tissue engineering. Previous work has suggested the importance of a…”
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Megakaryocytes respond during sepsis and display innate immune cell behaviors by Frydman, Galit H, Ellett, Felix, Jorgensen, Julianne, Marand, Anika L, Zukerberg, Lawrence, Selig, Martin K, Tessier, Shannon N, Wong, Keith H K, Olaleye, David, Vanderburg, Charles R, Fox, James G, Tompkins, Ronald G, Irimia, Daniel

“…Megakaryocytes (MKs) are precursors to platelets, the second most abundant cells in the peripheral circulation. However, while platelets are known to…”
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The Role of Physical Stabilization in Whole Blood Preservation by Wong, Keith H. K., Sandlin, Rebecca D., Carey, Thomas R., Miller, Kathleen L., Shank, Aaron T., Oklu, Rahmi, Maheswaran, Shyamala, Haber, Daniel A., Irimia, Daniel, Stott, Shannon L., Toner, Mehmet

“…The rapid degradation of blood ex vivo imposes logistical limitations on the utilization of blood-borne cells in medical diagnostics and scientific…”
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Microengineering in cardiovascular research: new developments and translational applications by Chan, Juliana M, Wong, Keith H K, Richards, Arthur Mark, Drum, Chester L

“…Microfluidic, cellular co-cultures that approximate macro-scale biology are important tools for refining the in vitro study of organ-level function and…”
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Ultra-fast vitrification of patient-derived circulating tumor cell lines by Sandlin, Rebecca D, Wong, Keith H K, Tessier, Shannon N, Swei, Anisa, Bookstaver, Lauren D, Ahearn, Bennett E, Maheswaran, Shyamala, Haber, Daniel A, Stott, Shannon L, Toner, Mehmet

“…Emerging technologies have enabled the isolation and characterization of rare circulating tumor cells (CTCs) from the blood of metastatic cancer patients. CTCs…”
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