Search Results - "Wong, Kari E."

Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents by Goedeke, Leigh, Bates, Jamie, Vatner, Daniel F., Perry, Rachel J., Wang, Ting, Ramirez, Ricardo, Li, Li, Ellis, Matthew W., Zhang, Dongyan, Wong, Kari E., Beysen, Carine, Cline, Gary W., Ray, Adrian S., Shulman, Gerald I.

“…Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for nonalcoholic fatty liver disease…”
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Serum Metabolites Associated with Healthy Diets in African Americans and European Americans by Kim, Hyunju, Hu, Emily A, E Wong, Kari, Yu, Bing, Steffen, Lyn M, Seidelmann, Sara B, Boerwinkle, Eric, Coresh, Josef, Rebholz, Casey M

“…High diet quality is associated with a lower risk of chronic diseases. Metabolomics can be used to identify objective biomarkers of diet quality. We used…”
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Metabolomic Markers of Ultra-Processed Food and Incident CKD by Su, Donghan, Chen, Jingsha, Du, Shutong, Kim, Hyunju, Yu, Bing, Wong, Kari E, Boerwinkle, Eric, Rebholz, Casey M

“…High ultra-processed food consumption is associated with higher risk of CKD. However, there is no biomarker for ultra-processed food, and the mechanism through…”
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1,25-Dihydroxyvitamin D3 Suppresses Renin Gene Transcription by Blocking the Activity of the Cyclic AMP Response Element in the Renin Gene Promoter by Yuan, Weihua, Pan, Wei, Kong, Juan, Zheng, Wei, Szeto, Frances L., Wong, Kari E., Cohen, Ronald, Klopot, Anna, Zhang, Zhongyi, Li, Yan Chun

“…We have shown that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) down-regulates renin expression. To explore the molecular mechanism, we analyzed the mouse Ren-1c…”
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Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise by Seiler, Sarah E., Koves, Timothy R., Gooding, Jessica R., Wong, Kari E., Stevens, Robert D., Ilkayeva, Olga R., Wittmann, April H., DeBalsi, Karen L., Davies, Michael N., Lindeboom, Lucas, Schrauwen, Patrick, Schrauwen-Hinderling, Vera B., Muoio, Deborah M.

“…Acylcarnitine metabolites have gained attention as biomarkers of nutrient stress, but their physiological relevance and metabolic purpose remain…”
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Targeted Expression of Human Vitamin D Receptor in Adipocytes Decreases Energy Expenditure and Induces Obesity in Mice by Wong, Kari E., Kong, Juan, Zhang, Wenshuo, Szeto, Frances L., Ye, Honggang, Deb, Dilip K., Brady, Matthew J., Li, Yan Chun

“…Our previous studies demonstrated a high fat diet-resistant lean phenotype of vitamin D receptor (VDR)-null mutant mice mainly due to increased energy…”
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Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins by Wong, Kari E, Szeto, Frances L, Zhang, Wenshuo, Ye, Honggang, Kong, Juan, Zhang, Zhongyi, Sun, Xiao Jian, Li, Yan Chun

“…Recent studies have established that vitamin D plays multiple biological roles beyond calcium metabolism; however, whether vitamin D is involved in energy…”
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Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis by Salic, Kanita, Gart, Eveline, Seidel, Florine, Verschuren, Lars, Caspers, Martien, van Duyvenvoorde, Wim, Wong, Kari E, Keijer, Jaap, Bobeldijk-Pastorova, Ivana, Wielinga, Peter Y, Kleemann, Robert

“…Obesity characterized by adiposity and ectopic fat accumulation is associated with the development of non-alcoholic fatty liver disease (NAFLD). Treatments…”
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Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes by Deb, Dilip K., Sun, Tao, Wong, Kari E., Zhang, Zhongyi, Ning, Gang, Zhang, Yan, Kong, Juan, Shi, Helen, Chang, Anthony, Li, Yan Chun

“…We recently showed that losartan and paricalcitol are synergistic in the treatment of diabetic nephropathy in a model of type 1 diabetes. To test this strategy…”
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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury by Beaudoin, James J, Clemens, Lara, Miedel, Mark T, Gough, Albert, Zaidi, Fatima, Ramamoorthy, Priya, Wong, Kari E, Sarangarajan, Rangaprasad, Battista, Christina, Shoda, Lisl K M, Siler, Scott Q, Taylor, D Lansing, Howell, Brett A, Vernetti, Lawrence A, Yang, Kyunghee

“…Biologics address a range of unmet clinical needs, but the occurrence of biologics-induced liver injury remains a major challenge. Development of cimaglermin…”
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Vitamin D Receptor Signaling Inhibits Atherosclerosis in Mice by Szeto, Frances L, Reardon, Catherine A, Yoon, Dosuk, Wang, Youli, Wong, Kari E, Chen, Yunzi, Kong, Juan, Liu, Shu Q, Thadhani, Ravi, Getz, Godfrey S, Li, Yan Chun

“…Although vitamin D has been implicated in cardiovascular protection, few studies have addressed the role of vitamin D receptor (VDR) in atherosclerosis. Here…”
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Serum Metabolomic Markers of Protein-Rich Foods and Incident CKD: Results From the Atherosclerosis Risk in Communities Study by Bernard, Lauren, Chen, Jingsha, Kim, Hyunju, Wong, Kari E., Steffen, Lyn M., Yu, Bing, Boerwinkle, Eric, Levey, Andrew S., Grams, Morgan E., Rhee, Eugene P., Rebholz, Casey M.

“…While urine excretion of nitrogen estimates the total protein intake, biomarkers of specific dietary protein sources have been sparsely studied. Using…”
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Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells by West, Michael D, Chang, Ching-Fang, Larocca, Dana, Li, Jie, Jiang, Jianjie, Sim, Pamela, Labat, Ivan, Chapman, Karen B, Wong, Kari E, Nicoll, James, Van Kanegan, Michael J, de Grey, Aubrey D N J, Nasonkin, Igor O, Stahl, Andreas, Sternberg, Hal

“…The role of brown fat in non-shivering thermogenesis and the discovery of brown fat depots in adult humans has made it the subject of intense research…”
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Loss of Vitamin D Receptor Produces Polyuria by Increasing Thirst by JUAN KONG, ZHONGYI ZHANG, DONGDONG LI, WONG, Kari E, YAN ZHANG, SZETO, Frances L, MUSCH, Mark W, YAN CHUN LI

“…Vitamin D receptor (VDR)-null mice develop polyuria, but the underlying mechanism remains unknown. In this study, we investigated the relationship between…”
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Serum metabolomic signatures of plant-based diets and incident chronic kidney disease by Kim, Hyunju, Yu, Bing, Li, Xin, Wong, Kari E, Boerwinkle, Eric, Seidelmann, Sara B, Levey, Andrew S, Rhee, Eugene P, Coresh, Josef, Rebholz, Casey M

“…Greater adherence to plant-based diets is associated with a lower risk of incident chronic kidney disease (CKD). Metabolomics can help identify blood…”
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Butyrate-Producing Bacteria and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) by Cui, Jinrui, Ramesh, Gautam, Wu, Martin, Jensen, Elizabeth T, Crago, Osa, Bertoni, Alain G, Gao, Chunxu, Hoffman, Kristi L, Sheridan, Patricia A, Wong, Kari E, Wood, Alexis C, Chen, Yii-Der I, Rotter, Jerome I, Petrosino, Joseph F, Rich, Stephen S, Goodarzi, Mark O

“…Gut microbiome studies have documented depletion of butyrate-producing taxa in type 2 diabetes. We analyzed associations between butyrate-producing taxa and…”
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Urine Metabolites Associated with the Dietary Approaches to Stop Hypertension (DASH) Diet: Results from the DASH‐Sodium Trial by Kim, Hyunju, Lichtenstein, Alice H., Wong, Kari E., Appel, Lawrence J., Coresh, Josef, Rebholz, Casey M.

“…Scope Serum metabolomic markers of the Dietary Approaches to Stop Hypertension (DASH) diet are previously reported. In an independent study, the similarity of…”
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Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Dietary Interventions by Kim, Hyunju, Appel, Lawrence J., Lichtenstein, Alice H., Wong, Kari E., Chatterjee, Nilanjan, Rhee, Eugene P., Rebholz, Casey M.

“…The DASH (Dietary Approaches to Stop Hypertension) diets reduced blood pressure (BP) in the DASH and DASH-Sodium trials, but the underlying mechanisms are…”
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Increased Plasma Branched Short-Chain Fatty Acids and Improved Glucose Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) by Aslamy, Arianne, Wood, Alexis C, Jensen, Elizabeth T, Bertoni, Alain G, Sheridan, Patricia A, Wong, Kari E, Ramesh, Gautam, Rotter, Jerome I, Chen, Yii-Der I, Goodarzi, Mark O

“…Short-chain fatty acids (SCFAs) have been extensively studied for potential beneficial roles in glucose homeostasis and risk of diabetes; however, most of this…”
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Serum Metabolomic Markers of Dairy Consumption: Results from the Atherosclerosis Risk in Communities Study and the Bogalusa Heart Study by Bernard, Lauren, Chen, Jingsha, Kim, Hyunju, Huang, Zhijie, Bazzano, Lydia, Qi, Lu, He, Jiang, Rao, Varun S, Potts, Kaitlin S, Kelly, Tanika N, Wong, Kari E, Steffen, Lyn M, Yu, Bing, Rhee, Eugene P, Rebholz, Casey M

“…Dairy consumption is related to chronic disease risk; however, the measurement of dairy consumption has largely relied upon self-report. Untargeted…”
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