Search Results - "Wong, Jenny C.Y."

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers by Mullarky, Edouard, Lucki, Natasha C., Zavareh, Reza Beheshti, Anglin, Justin L., Gomes, Ana P., Nicolay, Brandon N., Wong, Jenny C. Y., Christen, Stefan, Takahashi, Hidenori, Singh, Pradeep K., Blenis, John, Warren, J. David, Fendt, Sarah-Maria, Asara, John M., DeNicola, Gina M., Lyssiotis, Costas A., Lairson, Luke L., Cantley, Lewis C.

“…Cancer cells reprogram their metabolism to promote growth and proliferation. The genetic evidence pointing to the importance of the amino acid serine in…”
Get full text

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy by Lundquist, Mark R., Goncalves, Marcus D., Loughran, Ryan M., Possik, Elite, Vijayaraghavan, Tarika, Yang, Annan, Pauli, Chantal, Ravi, Archna, Verma, Akanksha, Yang, Zhiwei, Johnson, Jared L., Wong, Jenny C.Y., Ma, Yilun, Hwang, Katie Seo-Kyoung, Weinkove, David, Divecha, Nullin, Asara, John M., Elemento, Olivier, Rubin, Mark A., Kimmelman, Alec C., Pause, Arnim, Cantley, Lewis C., Emerling, Brooke M.

“…While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P2) in mammalian cells is generated by the conversion of phosphatidylinositol-4-phosphate…”
Get full text

Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant by Cohen, Sarah Beaussant, Bainter, Wayne, Johnson, Jared L., Lin, Ting-Yu, Wong, Jenny C.Y., Wallace, Jacqueline G., Jones, Jennifer, Qureshi, Sonia, Mir, Fatima, Qamar, Farah, Cantley, Lewis C., Geha, Raif S., Chou, Janet

“…This case demonstrates the essential contribution of the p110δ catalytic 21 domain in adaptive immunity function in a patient with expression of a kinase-dead…”
Get full text