Search Results - "Wong, Jason C."

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice by Tian, Jing-Hui, Patel, Nita, Haupt, Robert, Zhou, Haixia, Weston, Stuart, Hammond, Holly, Logue, James, Portnoff, Alyse D., Norton, James, Guebre-Xabier, Mimi, Zhou, Bin, Jacobson, Kelsey, Maciejewski, Sonia, Khatoon, Rafia, Wisniewska, Malgorzata, Moffitt, Will, Kluepfel-Stahl, Stefanie, Ekechukwu, Betty, Papin, James, Boddapati, Sarathi, Jason Wong, C., Piedra, Pedro A., Frieman, Matthew B., Massare, Michael J., Fries, Louis, Bengtsson, Karin Lövgren, Stertman, Linda, Ellingsworth, Larry, Glenn, Gregory, Smith, Gale

“…The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine to effectuate herd protection and control…”
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Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition by Pavankumar, Theetha L, Wong, C Jason, Wong, Yun Ka, Spies, Maria, Kowalczykowski, Stephen C

“…Abstract The loading of RecA onto ssDNA by RecBCD is an essential step of RecBCD-mediated homologous recombination. RecBCD facilitates RecA-loading onto ssDNA…”
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Managing Dry Eye Disease with Novel Medications: Mechanism, Study Validity, Safety, Efficacy, and Practical Application by Wong, Jason C, Barak, Aselle

“…Dry eye disease (DED) is a common condition that affects mainly older individuals and women. It is characterized by reduced tear production and increased tear…”
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Structural Analysis of Adenovirus VAI RNA Defines the Mechanism of Inhibition of PKR by Launer-Felty, Katherine, Wong, C. Jason, Cole, James L.

“…Protein kinase R (PKR) is activated by dsRNA produced during virus replication and plays a major role in the innate immunity response to virus infection. In…”
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Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction by Zhang, Zhisen, Lin, Zhaohu, Zhou, Zheng, Shen, Hong C, Yan, S. Frank, Mayweg, Alexander V, Xu, Zhiheng, Qin, Ning, Wong, Jason C, Zhang, Zhenshan, Rong, Yiping, Fry, David C, Hu, Taishan

“…The YAP–TEAD protein–protein interaction (PPI) mediates the oncogenic function of YAP, and inhibitors of this PPI have potential usage in treatment of…”
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Identifying Pertinent Digital Health Topics to Incorporate into Self-Care Pharmacy Education by Wong, Jason C, Hekimyan, Luiza, Cruz, Francheska Anne, Brower, Taylor

“…The ever-evolving landscape of digital health technology has dramatically enhanced patients' ability to manage their health through self-care effectively…”
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Domain-Selective Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6)-Mediated Tubulin Deacetylation by Haggarty, Stephen J., Koeller, Kathryn M., Wong, Jason C., Grozinger, Christina M., Schreiber, Stuart L.

“…Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four small-molecule histone…”
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Activation of PKR by short stem-loop RNAs containing single-stranded arms by Mayo, Christopher B, Wong, C Jason, Lopez, Prisma E, Lary, Jeffrey W, Cole, James L

“…Protein kinase R (PKR) is a central component of the innate immunity antiviral pathway and is activated by dsRNA. PKR contains a C-terminal kinase domain and…”
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Nonspecific Signs and/or Symptoms of Cancer: A Retrospective, Observational Analysis from a Secondary Care, US Community Oncology Dataset by Benton, Christopher B, He, Ding, Todoroff, Karen, Coignet, Marie V, Luan, Ying, Wong, Jason C, Kurtzman, Kathryn N, Zackon, Ira

“…To help determine the unmet need for improved diagnostic tools to evaluate patients with nonspecific signs and/or symptoms (NSSS) and suspicion of cancer, we…”
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Examining General Vaccine Acceptance and COVID-19 Vaccine Intention: Comparison across Pharmacies in California and Ohio by Mercadante, Amanda R, Chen, Aleda M H, Chu, Vivian, Wong, Jason C, Law, Anandi V

“…Given the complexities surrounding vaccine acceptance of COVID-19 and other vaccines, it is important to determine the underlying health beliefs of patients in…”
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Fast Tracking—Vaccine Safety, Efficacy, and Lessons Learned: A Narrative Review by Wong, Jason C, Lao, Crystal T, Yousif, Melanie M, Luga, Jacqueline M

“…(1) Background: The COVID-19 pandemic has led to the fast-tracked development of vaccines under emergency use authorization. In light of the growing concerns…”
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Cerebral grey, white matter and csf in never-medicated, first-episode schizophrenia by Chua, Siew E, Cheung, Charlton, Cheung, Vinci, Tsang, Jack T.K, Chen, Eric Y.H, Wong, Jason C.H, Cheung, Jason P.Y, Yip, Lawrance, Tai, Kin-shing, Suckling, John, McAlonan, Gráinne M

“…Abstract We report the first voxel-based morphometric (VBM) study to examine cerebral grey and white matter and cerebrospinal fluid (CSF) using computational…”
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Perceived levels of collaboration between cancer patients and their providers during radiation therapy by Lee, Charlotte T, Wong, Jason C

“…This study described the patterns within collaborative relationships between patients and health care professionals during radiation therapy (RT). A one-time…”
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Structural Biasing Elements for In-Cell Histone Deacetylase Paralog Selectivity by Wong, Jason C, Hong, Roger, Schreiber, Stuart L

“…We use the structural dissection of two 1,3-dioxanes with in-cell histone deacetylase (HDAC) paralog selectivity to identify key elements for selective HDAC…”
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Biodiversity and thermal ecological function: The influence of freshwater algal diversity on local thermal environments by Missirian, Anouch, Frank, Eyal G., Gersony, Jess T., Wong, Jason C. Y., Naeem, Shahid

“…The influence of temperature on diversity and ecosystem functioning is well studied; the converse however, that is, how biodiversity influences temperature,…”
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Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy by Wong, Jason C., Guo, Lei, Peng, Zhenghong, Zhang, Weixing, Zhang, Nan, Lai, Wayne, Zhang, Zhenshan, Zhang, Chao, Zhang, Xiongwen, Song, Shan, Pan, Desi, Xie, Chuanming, Li, Jia, Ning, Zhiqing, Lu, Xianping, He, Yun, Chen, Li

“…Novel 2-aminoanilide histone deacetylase (HDAC) inhibitors were designed to increase their contact with surface residues surrounding the HDAC active site…”
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The association among cancer patients’ collaboration with their healthcare providers, self‐management and well‐being during radiotherapy: An observational, cross‐sectional survey by Lee, Charlotte T., Vanderwater, Catherine, Pickrell, Wyatt, Wong, Jason C.

“…Objectives Patients adapt to cancer through self‐management, which requires collaboration between patients and their healthcare providers. We aimed to describe…”
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Degrés de collaboration perçus entre les patients atteints de cancer et leurs prestataires de soins pendant la radiothérapie by Lee, Charlotte T, Wong, Jason C

“…Cette étude décrit les tendances en matière de relations collaboratives entre les patients et les professionnels de la santé pendant la radiothérapie. Pour ce…”
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Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors by Tang, Guozhi, Wong, Jason C, Zhang, Weixing, Wang, Zhanguo, Zhang, Nan, Peng, Zhenghong, Zhang, Zhenshan, Rong, Yiping, Li, Shijie, Zhang, Meifang, Yu, Lingjie, Feng, Teng, Zhang, Xiongwen, Wu, Xihan, Wu, Jim Z, Chen, Li

“…Herein we report the identification of a novel class of HDAC6 and HDAC8 selective inhibitors through a unique chemistry and phenotypic screening strategy…”
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Assessing Ability for ChatGPT to Answer Total Knee Arthroplasty-Related Questions by Magruder, Matthew L., Rodriguez, Ariel N., Wong, Jason C.J., Erez, Orry, Piuzzi, Nicolas S., Scuderi, Gil R., Slover, James D., Oh, Jason H., Schwarzkopf, Ran, Chen, Antonia F., Iorio, Richard, Goodman, Stuart B., Mont, Michael A.

“…Artificial intelligence in the field of orthopaedics has been a topic of increasing interest and opportunity in recent years. Its applications are widespread…”
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