Search Results - "Wong, Iris PL"

Neuropeptide Y is a critical modulator of Leptin's regulation of cortical bone by Wong, Iris PL, Nguyen, Amy D, Khor, Ee Cheng, Enriquez, Ronaldo F, Eisman, John A, Sainsbury, Amanda, Herzog, Herbert, Baldock, Paul A

“…Leptin signaling is required for normal bone homeostasis; however, loss of leptin results in differing effects on cortical and cancellous bone, as well as…”
Get full text

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway by Ollila, Saara, Domènech-Moreno, Eva, Laajanen, Kaisa, Wong, Iris Pl, Tripathi, Sushil, Pentinmikko, Nalle, Gao, Yajing, Yan, Yan, Niemelä, Elina H, Wang, Timothy C, Viollet, Benoit, Leone, Gustavo, Katajisto, Pekka, Vaahtomeri, Kari, Mäkelä, Tomi P

“…Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse…”
Get full text

Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight by Baldock, Paul A, Lee, Nicola J, Driessler, Frank, Lin, Shu, Allison, Susan, Stehrer, Bernhard, Lin, En-Ju D, Zhang, Lei, Enriquez, Ronald F, Wong, Iris P L, McDonald, Michelle M, During, Matthew, Pierroz, Dominique D, Slack, Katy, Shi, Yan C, Yulyaningsih, Ernie, Aljanova, Aygul, Little, David G, Ferrari, Serge L, Sainsbury, Amanda, Eisman, John A, Herzog, Herbert

“…Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the…”
Get full text

Abstract C55: Investigating mechanisms of gastrointestinal polyposis and osteoblastic tumor formation induced by mesenchymal Lkb1 deficiency by Laajanen, Kaisa, Ollila, Saara, Wong, Iris PL, Vaahtomeri, Kari, Leone, Gustavo, Viollet, Benoit, Tomi, Makela P.

“…Lkb1 has emerged as an important tumor suppressor gene in both sporadic and hereditary cancer. Inactivating germline mutations in the LKB1 gene underlie…”
Get full text

NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice by Shi, Yan-Chuan, Lin, Shu, Wong, Iris P L, Baldock, Paul A, Aljanova, Aygul, Enriquez, Ronaldo F, Castillo, Lesley, Mitchell, Natalie F, Ye, Ji-Ming, Zhang, Lei, Macia, Laurence, Yulyaningsih, Ernie, Nguyen, Amy D, Riepler, Sabrina J, Herzog, Herbert, Sainsbury, Amanda

“…Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-mediated effects on energy homeostasis and bone physiology. Y2 receptors are located…”
Get full text

Gastrointestinal peptides and bone health by Wong, Iris Pl, Baldock, Paul A, Herzog, Herbert

“…To outline recent developments in research surrounding gastrointestinal peptides and their role in skeletal regulation. Bone remodeling is influenced by many…”
Get full text

The endogenous opioid dynorphin is required for normal bone homeostasis in mice by Baldock, Paul A, Driessler, Frank, Lin, Shu, Wong, Iris P.L, Shi, Yanchuan, Yulyaningsih, Ernie, Castillo, Lesley, Janmaat, Sonia, Enriquez, Ronaldo F, Zengin, Ayse, Kieffer, Brigitte L, Schwarzer, Christoph, Eisman, John A, Sainsbury, Amanda, Herzog, Herbert

“…Abstract Chronic opiate usage, whether prescribed or illicit, has been associated with changes in bone mass and is a recognized risk factor for the development…”
Get full text