Search Results - "Wong, Iris L K"

In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31 by Sun, Wenqin, Wong, Iris L K, Law, Helen Ka-Wai, Su, Xiaochun, Chan, Terry C F, Sun, Gege, Yang, Xinqing, Wang, Xingkai, Chan, Tak Hang, Wan, Shengbiao, Chow, Larry M C

“…The modulation of P-glycoprotein (P-gp, ABCB1) can reverse multidrug resistance (MDR) and potentiate the efficacy of anticancer drugs. Tea polyphenols, such as…”
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In Vitro and In Vivo Efficacy of Novel Flavonoid Dimers against Cutaneous Leishmaniasis by WONG, Iris L. K, CHAN, Kin-Fai, CHEN, Yun-Fu, LUN, Zhao-Rong, TAK HANG CHAN, CHOW, Larry M. C

“…Treatment of leishmaniasis by chemotherapy remains a challenge because of limited efficacy, toxic side effects, and drug resistance. We previously reported…”
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A New Class of Safe, Potent, and Specific P‑gp Modulator: Flavonoid Dimer FD18 Reverses P‑gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo by Yan, Clare S. W, Wong, Iris L. K, Chan, Kin-Fai, Kan, Jason W. Y, Chong, Tsz Cheung, Law, Man Chun, Zhao, Yunzhe, Chan, Shun Wan, Chan, Tak Hang, Chow, Larry M. C

“…Flavonoid dimer FD18 is a new class of dimeric P-gp modulator that can reverse cancer drug resistance. FD18 is a potent (EC50 = 148 nM for paclitaxel), safe…”
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Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors by Zhu, Xuezhen, Wong, Iris L. K, Chan, Kin-Fai, Cui, Jiahua, Law, Man Chun, Chong, Tsz Cheung, Hu, Xuesen, Chow, Larry M. C, Chan, Tak Hang

“…The present work describes the syntheses of diverse triazole bridged flavonoid dimers and identifies potent, nontoxic, and highly selective BCRP inhibitors. A…”
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Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with “Click Chemistry” by Wong, Iris L. K, Zhu, Xuezhen, Chan, Kin-Fai, Law, Man Chun, Lo, Aya M. Y, Hu, Xuesen, Chow, Larry M. C, Chan, Tak Hang

“…A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using “click chemistry”…”
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Flavonoid Dimers as Bivalent Modulators for Pentamidine and Sodium Stiboglucanate Resistance in Leishmania by Wong, Iris L K, Chan, Kin-Fai, Burkett, Brendan A, Zhao, Yunzhe, Chai, Yi, Sun, Hongzhe, Chan, Tak Hang, Chow, Larry M C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors by Chan, Kin-Fai, Sun, Ning, Yan, Siu-Cheong, Wong, Iris L. K, Lui, Hok-Kiu, Cheung, Kwan-Choi, Yuan, Jian, Chan, Fung-Yi, Zheng, Zhiwei, Chan, Edward W. C, Chen, Sheng, Leung, Yun-Chung, Chan, Tak Hang, Wong, Kwok-Yin

“…We have recently identified a new class of filamenting temperature-sensitive mutant Z (FtsZ)-interacting compounds that possess a 2,4,6-trisubstituted…”
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Amine-Linked Flavonoids as Agents Against Cutaneous Leishmaniasis by Chan, Chin-Fung, Liu, Zhen, Wong, Iris L K, Zhao, Xianliang, Yang, Zaofeng, Zheng, Jiale, Lee, Marianne M, Chan, Michael K, Chan, Tak Hang, Chow, Larry M C

“…We have designed, synthesized, and characterized a library of 38 novel flavonoid compounds linked with amines. Some of these amine-linked flavonoids have…”
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Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel by Kan, Jason W Y, Yan, Clare S W, Wong, Iris L K, Su, Xiaochun, Liu, Zhen, Chan, Tak Hang, Chow, Larry M C

“…Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04…”
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Potent and Nontoxic Chemosensitizer of P‑Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives by Wong, Iris L. K, Wang, Bao-Chao, Yuan, Jian, Duan, Liang-Xing, Liu, Zhen, Liu, Tao, Li, Xue-Min, Hu, Xuesen, Zhang, Xiao-Yu, Jiang, Tao, Wan, Sheng-Biao, Chow, Larry M. C

“…We are interested in developing novel natural product-derived P-gp inhibitors to reverse cancer drug resistance. Here, we have synthesized 55 novel derivatives…”
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Flavonoid Dimers as Bivalent Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure-Activity Relationships by Chan, Kin-Fai, Zhao, Yunzhe, Chow, Toby W. S., Yan, Clare S. W., Ma, Dik Lung, Burkett, Brendan A., Wong, Iris L. K., Chow, Larry M. C., Chan, Tak Hang

“…Bivalent modulators of P‐glycoprotein: A small library of flavonoid homodimers and heterodimers was synthesized, and their in vitro activity in reversing…”
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Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2) by Chong, Tsz Cheung, Wong, Iris L. K., Cui, Jiahua, Law, Man Chun, Zhu, Xuezhen, Hu, Xuesen, Kan, Jason W. Y., Yan, Clare S. W., Chan, Tak Hang, Chow, Larry M. C.

“…Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the…”
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Amine Linked Flavonoid Dimers as Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure–Activity Relationship and Mechanism of Modulation by Chan, Kin-Fai, Wong, Iris L. K, Kan, Jason W. Y, Yan, Clare S. W, Chow, Larry M. C, Chan, Tak Hang

“…Here we report a great improvement in reversal potency of cancer drug resistance when flavonoid dimers possess a functionally substituted aminopolyethylene…”
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Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania by Wong, Iris L. K., Chan, Kin-Fai, Zhao, Yunzhe, Chan, Tak Hang, Chow, Larry M. C.

“…Objectives The aim of this study was to investigate the synergistic effect of quinacrine and a novel apigenin dimer (compound 9d) on reversing pentamidine…”
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Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells by Yuan, Jian, Wong, Iris L.K., Jiang, Tao, Wang, Si Wen, Liu, Tao, Jin Wen, Bin, Chow, Larry M.C., Wan Sheng, Biao

“…Three methylated quercetins and a series of O-3 substituted 5,7,3′,4′-tetra-O-methylated quercetin derivatives have been synthesized and evaluated on the…”
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Flavonoid Dimers as Novel, Potent Antileishmanial Agents by Wong, Iris L. K, Chan, Kin-Fai, Chan, Tak Hang, Chow, Larry M. C

“…The present study found that synthetic flavonoid dimers with either polyethylene glycol linker or amino ethyleneglycol linker have marked leishmanicidal…”
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Structure–Activity Relationship Study of Permethyl Ningalin B Analogues as P‑Glycoprotein Chemosensitizers by Bin, Jin Wen, Wong, Iris L. K, Hu, Xuesen, Yu, Zhang Xiao, Xing, Li Fu, Jiang, Tao, Chow, Larry M. C, Biao, Wan Sheng

“…A novel series of permethyl ningalin B analogues were synthesized and evaluated for their P-glycoprotein (P-gp)-modulating activities in a P-gp-overexpressing…”
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Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Multidrug Resistance by Bivalent Apigenin Homodimers and Their Derivatives by Wong, Iris L. K, Chan, Kin-Fai, Tsang, Ka Hing, Lam, Chi Yin, Zhao, Yunzhe, Chan, Tak Hang, Chow, Larry Ming Cheung

“…Here we showed that bivalency approach is effective in modulating multidrug resistance protein 1 (MRP1/ABCC1)-mediated doxorubicin (DOX) and etoposide (VP16)…”
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Localization of Epigenetic Markers in Leishmania Chromatin by McDonald, Jacquelyn R., Jensen, Bryan C., Sur, Aakash, Wong, Iris L. K., Beverley, Stephen M., Myler, Peter J.

“…Eukaryotes use histone variants and post-translation modifications (PTMs), as well as DNA base modifications, to regulate DNA replication/repair, chromosome…”
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Design and Syntheses of Permethyl Ningalin B Analogues: Potent Multidrug Resistance (MDR) Reversal Agents of Cancer Cells by Zhang, Pu Yong, Wong, Iris L. K, Yan, Clare S. W, Zhang, Xiao Yu, Jiang, Tao, Chow, Larry M. C, Wan, Sheng Biao

“…A series of novel N-arylalkyl-3,4-diaryl-substituted pyrrole-2,5-diones were synthesized. They exhibited promising P-gp modulating activity in a P-gp…”
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