Search Results - "Wong, Iris"

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway by Ollila, Saara, Domènech-Moreno, Eva, Laajanen, Kaisa, Wong, Iris Pl, Tripathi, Sushil, Pentinmikko, Nalle, Gao, Yajing, Yan, Yan, Niemelä, Elina H, Wang, Timothy C, Viollet, Benoit, Leone, Gustavo, Katajisto, Pekka, Vaahtomeri, Kari, Mäkelä, Tomi P

“…Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse…”
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Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors by Zhu, Xuezhen, Wong, Iris L. K, Chan, Kin-Fai, Cui, Jiahua, Law, Man Chun, Chong, Tsz Cheung, Hu, Xuesen, Chow, Larry M. C, Chan, Tak Hang

“…The present work describes the syntheses of diverse triazole bridged flavonoid dimers and identifies potent, nontoxic, and highly selective BCRP inhibitors. A…”
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Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2) by Wong, Iris L.K, Zhu, Xuezhen, Chan, Kin-Fai, Liu, Zhen, Chan, Chin-Fung, Chow, Tsun Sing, Chong, Tsz Cheung, Law, Man Chun, Cui, Jiahua, Chow, Larry M.C, Chan, Tak Hang

“…We synthesize various substituted triazole-containing flavonoids and identify potent, nontoxic, and highly selective BCRP inhibitors. Ac18Az8, Ac32Az19, and…”
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Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with “Click Chemistry” by Wong, Iris L. K, Zhu, Xuezhen, Chan, Kin-Fai, Law, Man Chun, Lo, Aya M. Y, Hu, Xuesen, Chow, Larry M. C, Chan, Tak Hang

“…A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using “click chemistry”…”
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Inactivation of AMPK Leads to Attenuation of Antigen Presentation and Immune Evasion in Lung Adenocarcinoma by Gao, Yajing, Päivinen, Pekka, Tripathi, Sushil, Domènech-Moreno, Eva, Wong, Iris P L, Vaahtomeri, Kari, Nagaraj, Ashwini S, Talwelkar, Sarang S, Foretz, Marc, Verschuren, Emmy W, Viollet, Benoit, Yan, Yan, Mäkelä, Tomi P

“…Mutations in ( ) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to…”
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Targeted delivery of antimicrobial peptide by Cry protein crystal to treat intramacrophage infection by Yang, Zaofeng, Zheng, Jiale, Chan, Chin-Fung, Wong, Iris L.K., Heater, Bradley S., Chow, Larry M.C., Lee, Marianne M.M., Chan, Michael K.

“…Antimicrobial peptides (AMPs) have recently attracted great attention due to their rapid action, broad spectrum of activity, and low propensity of resistance…”
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Peptide YY regulates bone remodeling in mice: a link between gut and skeletal biology by Wong, Iris P L, Driessler, Frank, Khor, Ee Cheng, Shi, Yan-Chuan, Hörmer, Birgit, Nguyen, Amy D, Enriquez, Ronaldo F, Eisman, John A, Sainsbury, Amanda, Herzog, Herbert, Baldock, Paul A

“…Gastrointestinal peptides are increasingly being linked to processes controlling the maintenance of bone mass. Peptide YY (PYY), a gut-derived satiety peptide…”
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In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31 by Sun, Wenqin, Wong, Iris L K, Law, Helen Ka-Wai, Su, Xiaochun, Chan, Terry C F, Sun, Gege, Yang, Xinqing, Wang, Xingkai, Chan, Tak Hang, Wan, Shengbiao, Chow, Larry M C

“…The modulation of P-glycoprotein (P-gp, ABCB1) can reverse multidrug resistance (MDR) and potentiate the efficacy of anticancer drugs. Tea polyphenols, such as…”
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Amine-Linked Flavonoids as Agents Against Cutaneous Leishmaniasis by Chan, Chin-Fung, Liu, Zhen, Wong, Iris L K, Zhao, Xianliang, Yang, Zaofeng, Zheng, Jiale, Lee, Marianne M, Chan, Michael K, Chan, Tak Hang, Chow, Larry M C

“…We have designed, synthesized, and characterized a library of 38 novel flavonoid compounds linked with amines. Some of these amine-linked flavonoids have…”
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Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight by Baldock, Paul A, Lee, Nicola J, Driessler, Frank, Lin, Shu, Allison, Susan, Stehrer, Bernhard, Lin, En-Ju D, Zhang, Lei, Enriquez, Ronald F, Wong, Iris P L, McDonald, Michelle M, During, Matthew, Pierroz, Dominique D, Slack, Katy, Shi, Yan C, Yulyaningsih, Ernie, Aljanova, Aygul, Little, David G, Ferrari, Serge L, Sainsbury, Amanda, Eisman, John A, Herzog, Herbert

“…Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the…”
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LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate by Gao, Yajing, Yan, Yan, Tripathi, Sushil, Pentinmikko, Nalle, Amaral, Ana, Päivinen, Pekka, Domènech-Moreno, Eva, Andersson, Simon, Wong, Iris P.L., Clevers, Hans, Katajisto, Pekka, Mäkelä, Tomi P.

“…In addition to the Notch and Wnt signaling pathways, energy metabolism also regulates intestinal stem cell (ISC) function. Tumor suppressor and kinase STK11…”
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In Vitro and In Vivo Efficacy of Novel Flavonoid Dimers against Cutaneous Leishmaniasis by WONG, Iris L. K, CHAN, Kin-Fai, CHEN, Yun-Fu, LUN, Zhao-Rong, TAK HANG CHAN, CHOW, Larry M. C

“…Treatment of leishmaniasis by chemotherapy remains a challenge because of limited efficacy, toxic side effects, and drug resistance. We previously reported…”
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NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice by Shi, Yan-Chuan, Lin, Shu, Wong, Iris P L, Baldock, Paul A, Aljanova, Aygul, Enriquez, Ronaldo F, Castillo, Lesley, Mitchell, Natalie F, Ye, Ji-Ming, Zhang, Lei, Macia, Laurence, Yulyaningsih, Ernie, Nguyen, Amy D, Riepler, Sabrina J, Herzog, Herbert, Sainsbury, Amanda

“…Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-mediated effects on energy homeostasis and bone physiology. Y2 receptors are located…”
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Potent and Nontoxic Chemosensitizer of P‑Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives by Wong, Iris L. K, Wang, Bao-Chao, Yuan, Jian, Duan, Liang-Xing, Liu, Zhen, Liu, Tao, Li, Xue-Min, Hu, Xuesen, Zhang, Xiao-Yu, Jiang, Tao, Wan, Sheng-Biao, Chow, Larry M. C

“…We are interested in developing novel natural product-derived P-gp inhibitors to reverse cancer drug resistance. Here, we have synthesized 55 novel derivatives…”
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Identification of Binding Sites in the Nucleotide-Binding Domain of P‑Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04 by Liu, Zhen, Wong, Iris L. K., Sang, Jingcheng, Liu, Fufeng, Yan, Clare S. W., Kan, Jason W. Y., Chan, Tak Hang, Chow, Larry M. C.

“…We have previously discovered an amine-containing flavonoid monomer FM04 as a potent P-glycoprotein (P-gp) inhibitor (EC50 = 83 nM). Here, a series of…”
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Kinetoplastid-specific histone variant functions are conserved in Leishmania major by Anderson, Britta A., Wong, Iris L.K., Baugh, Loren, Ramasamy, Gowthaman, Myler, Peter J., Beverley, Stephen M.

“…•Histone variants H2A.Z and H2B.V are essential in Leishmania major.•Histone variant H3.V is not essential in L. major.•H3.V loss does not affect read-through…”
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Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel by Kan, Jason W Y, Yan, Clare S W, Wong, Iris L K, Su, Xiaochun, Liu, Zhen, Chan, Tak Hang, Chow, Larry M C

“…Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04…”
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Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers by Wong, Iris L.K., Wang, Xing-kai, Liu, Zhen, Sun, Wenqin, Li, Fu-xing, Wang, Bao-chao, Li, Peng, Wan, Sheng-biao, Chow, Larry M.C.

“…P-glycoprotein (P-gp; ABCB1)-mediated drug efflux causes multidrug resistance in cancer. Previous synthetic methylated epigallocatechin (EGC) possessed…”
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SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling by Yan, Yan, Ollila, Saara, Wong, Iris P. L., Vallenius, Tea, Palvimo, Jorma J., Vaahtomeri, Kari, Mäkelä, Tomi P.

“…AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate…”
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Disruption of SND1-MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo by Li, Peng, He, Yunjiao, Chen, Teng, Choy, Kit-Ying, Chow, Tsun Sing, Wong, Iris L K, Yang, Xinqing, Sun, Wenqin, Su, Xiaochun, Chan, Tak-Hang, Chow, Larry M C

“…Staphylococcal nuclease domain-containing protein 1 (SND1) is a multifunctional oncoprotein overexpressed in breast cancer. Binding of metadherin (MTDH) to…”
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