Search Results - "Wong, Ian Y."

Ocular Anti-VEGF Therapy for Diabetic Retinopathy: Overview of Clinical Efficacy and Evolving Applications by NING CHEUNG, WONG, Ian Y, WONG, Tien Y

“…Ocular anti-vascular endothelial growth factor (VEGF) therapy represents one of the most significant advances in modern medicine. The introduction and…”
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The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems by Leggett, Susan E, Hruska, Alex M, Guo, Ming, Wong, Ian Y

“…The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the intracellular cytoskeleton and the extracellular matrix. After EMT,…”
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Collective and individual migration following the epithelial–mesenchymal transition by Wong, Ian Y., Javaid, Sarah, Wong, Elisabeth A., Perk, Sinem, Haber, Daniel A., Toner, Mehmet, Irimia, Daniel

“…During cancer progression, malignant cells in the tumour invade surrounding tissues. This transformation of adherent cells to a motile phenotype has been…”
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Nanotechnology: emerging tools for biology and medicine by Wong, Ian Y, Bhatia, Sangeeta N, Toner, Mehmet

“…Historically, biomedical research has been based on two paradigms. First, measurements of biological behaviors have been based on bulk assays that average over…”
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Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields by Patel, Mohak, Leggett, Susan E., Landauer, Alexander K., Wong, Ian Y., Franck, Christian

“…Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing…”
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Antibody-Functionalized Fluid-Permeable Surfaces for Rolling Cell Capture at High Flow Rates by Mittal, Sukant, Wong, Ian Y., Deen, William M., Toner, Mehmet

“…Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. However, the…”
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Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer by Brodsky, Alexander S, Khurana, Jay, Guo, Kevin S, Wu, Elizabeth Y, Yang, Dongfang, Siddique, Ayesha S, Wong, Ian Y, Gamsiz Uzun, Ece D, Resnick, Murray B

“…Gastric cancer is a heterogeneous disease with poorly understood genetic and microenvironmental factors. Mutations in collagen genes are associated with…”
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Choroidal thickness in relation to hypercholesterolemia on enhanced depth imaging optical coherence tomography by Wong, Ian Y, Wong, Raymond L, Zhao, Paul, Lai, Wico W

“…To investigate the relationship of hypercholesterolemia and choroidal thickness in normal healthy volunteers. This was a cross-sectional observational study…”
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Long-term follow-up of cytomegalovirus retinitis in non-HIV immunocompromised patients: clinical features and visual prognosis by Iu, Lawrence P, Fan, Michelle C, Lau, Jordy K, Chan, Thomas S, Kwong, Yok-Lam, Wong, Ian Y

“…Abstract Purpose To evaluate clinical features and long-term visual outcome of cytomegalovirus (CMV) retinitis in patients without human immunodeficiency virus…”
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Morphological single cell profiling of the epithelial-mesenchymal transition by Leggett, Susan E, Sim, Jea Yun, Rubins, Jonathan E, Neronha, Zachary J, Williams, Evelyn Kendall, Wong, Ian Y

“…Single cells respond heterogeneously to biochemical treatments, which can complicate the analysis of in vitro and in vivo experiments. In particular, stressful…”
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Directed Hybridization and Melting of DNA Linkers using Counterion-Screened Electric Fields by Wong, Ian Y, Melosh, Nicholas A

“…Dynamic self-assembly using responsive, “smart” materials such as DNA is a promising route toward reversible assembly and patterning of nanostructures for…”
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Choroidal thickness in school children: The Gobi Desert Children Eye Study by Zhu, Dan, Wang, Yan, Zheng, Yan Fei, Yang, Da Yong, Guo, Kai, Yang, Xian Rong, Jing, Xin Xia, Wong, Ian Y, You, Qi Sheng, Tao, Yong, Jonas, Jost B

“…To investigate choroidal thickness (CT) and its associations in children in a school-based study. The cross-sectional school-based Gobi Desert Children Eye…”
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Injectable silicone rubber for ocular implantation after evisceration by Zheng, Peng Fei, You, Qi Sheng, Li, Qian, Deng, Hong Yan, Wong, Ian Y H, Peng, Xiao Yan

“…To investigate the usefulness of addition type liquid silicone rubber (ATLSR) as injectable implant after evisceration to maintain the eyeball volume in an…”
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Topological data analysis of spatial patterning in heterogeneous cell populations: clustering and sorting with varying cell-cell adhesion by Bhaskar, Dhananjay, Zhang, William Y., Volkening, Alexandria, Sandstede, Björn, Wong, Ian Y.

“…Different cell types aggregate and sort into hierarchical architectures during the formation of animal tissues. The resulting spatial organization depends (in…”
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Incorporating Optical Coherence Tomography Macula Scans Enhances Cost-effectiveness of Fundus Photography-Based Screening for Diabetic Macular Edema by Wong, Ian Y H, Wong, Raymond L M, Chan, Jonathan C H, Kawasaki, Ryo, Chong, Victor

“…To compare four screening strategies for diabetic macular edema (DME). Patients attending diabetic retinopathy screening were recruited and received macular…”
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Multiscale Graphene Topographies Programmed by Sequential Mechanical Deformation by Chen, Po-Yen, Sodhi, Jaskiranjeet, Qiu, Yang, Valentin, Thomas M., Steinberg, Ruben Spitz, Wang, Zhongying, Hurt, Robert H., Wong, Ian Y.

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3D Printed Monolithic Device for the Microfluidic Capture, Perfusion, and Analysis of Multicellular Spheroids by Markoski, Alex, Wong, Ian Y, Borenstein, Jeffrey T

“…Microfluidic systems for the analysis of tissue models of cancer and other diseases are rapidly emerging, with an increasing recognition that perfusion is…”
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Multicellular tumor invasion and plasticity in biomimetic materials by Leggett, Susan E, Khoo, Amanda S, Wong, Ian Y

“…Cancer cell invasion through the extracellular matrix is associated with metastatic spread and therapeutic resistance. In carcinomas, the detachment and…”
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Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation by Lakis, Nelli S, Brodsky, Alexander S, Karashchuk, Galina, Audesse, Amanda J, Yang, Dongfang, Sturtevant, Ashlee, Lombardo, Kara, Wong, Ian Y, Webb, Ashley E, Anthony, Douglas C

“…A growing body of evidence supports the presence of a population of cells in glioblastoma (GBM) with a stem cell-like phenotype which shares certain biological…”
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Treatment of large, chronic and persistent macular hole with internal limiting membrane transposition and tuck technique by Fung, Nicholas S K, Mak, Anthony K H, Yiu, Rachel, Wong, Ian Y H, Lam, Wai Ching

“…Large, chronic full thickness macular holes which failed previous treatments are difficult to manage and even left untreated due to poor prognosis. A…”
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