Search Results - "Wong, Gordon Tin Chun"

Is exercise a senolytic medicine? A systematic review by Chen, Xiang‐Ke, Yi, Zhen‐Ni, Wong, Gordon Tin‐Chun, Hasan, Kazi Md. Mahmudul, Kwan, Joseph Shiu‐Kwong, Ma, Alvin Chun‐Hang, Chang, Raymond Chuen‐Chung

“…Cellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent…”
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Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling by Liu, Yanan, Jin, Jiqin, Qiao, Shigang, Lei, Shaoqing, Liao, Songyan, Ge, Zhi-Dong, Li, Haobo, Wong, Gordon Tin-Chun, Irwin, Michael G, Xia, Zhengyuan

“…Activation of PKCβ (protein kinase Cβ) plays a critical role in myocardial I/R (ischaemia/reperfusion) injury in non-diabetic rodents. In the myocardium of…”
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Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice by Chen, Ying, Joo, Jin, Chu, John Man-Tak, Chang, Raymond Chuen-Chung, Wong, Gordon Tin-Chun

“…Abstract Introduction Glucose transporter 1 (GLUT1) is essential for glucose transport into the brain and is predominantly expressed in the cerebral…”
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Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio) by Chen, Xiang-Ke, Kwan, Joseph Shiu-Kwong, Wong, Gordon Tin-Chun, Yi, Zhen-Ni, Ma, Alvin Chun-Hang, Chang, Raymond Chuen-Chung

“…Despite well-known systemic immune reactions in peripheral trauma, little is known about their roles in posttraumatic neurological disorders, such as anxiety,…”
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Preoperative dexmedetomidine prevents tourniquet-induced hypertension in orthopedic operation during general anesthesia by Lu, Yao, Zhang, Ye, Dong, Chun-Shan, Yu, Jun-Ma, Wong, Gordon Tin-Chun

“…Abstract This study was a double-blinded randomized control trial designed to investigate the hemodynamic effects of dexmedetomidine on prolonged tourniquet…”
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Cerebral Glutamate Regulation and Receptor Changes in Perioperative Neuroinflammation and Cognitive Dysfunction by Zhang, Yan, Chu, John-Man-Tak, Wong, Gordon-Tin-Chun

“…Glutamate is the major excitatory neurotransmitter in the central nervous system and is intricately linked to learning and memory. Its activity depends on the…”
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The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases by Liu, Yan, Yan, Tim, Chu, John Man-Tak, Chen, Ying, Dunnett, Sophie, Ho, Yuen-Shan, Wong, Gordon Tin-Chun, Chang, Raymond Chuen-Chung

“…Growing evidence has shown the beneficial influence of exercise on humans. Apart from classic cardioprotection, numerous studies have demonstrated that…”
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Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model by Huang, Chunxia, Irwin, Michael Garnet, Wong, Gordon Tin Chun, Chang, Raymond Chuen Chung

“…Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning and memory…”
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ChatGPT versus human in generating medical graduate exam multiple choice questions-A multinational prospective study (Hong Kong S.A.R., Singapore, Ireland, and the United Kingdom) by Cheung, Billy Ho Hung, Lau, Gary Kui Kai, Wong, Gordon Tin Chun, Lee, Elaine Yuen Phin, Kulkarni, Dhananjay, Seow, Choon Sheong, Wong, Ruby, Co, Michael Tiong-Hong

“…Large language models, in particular ChatGPT, have showcased remarkable language processing capabilities. Given the substantial workload of university medical…”
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Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice by Huang, Chunxia, Chu, John Man-Tak, Liu, Yan, Chang, Raymond Chuen-Chung, Wong, Gordon Tin-Chun

“…Postoperative cognitive dysfunction (POCD) occurs more frequently in elderly patients undergoing major surgery. Age associated cholinergic imbalance may…”
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Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer's disease mice by Liu, Yan, Chu, John Man Tak, Yan, Tim, Zhang, Yan, Chen, Ying, Chang, Raymond Chuen Chung, Wong, Gordon Tin Chun

“…Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance…”
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Bronchial Blocker Versus Left Double-Lumen Endotracheal Tube for One-Lung Ventilation in Right Video-Assisted Thoracoscopic Surgery by Lu, Yao, Dai, Wei, Zong, Zhijun, Xiao, Yimin, Wu, Di, Liu, Xuesheng, Chun Wong, Gordon Tin

“…The aim of this study was to compare the quality of lung deflation of a left-sided double-lumen endotracheal tube (DLT) with a bronchial blocker (BB) for…”
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A flipped classroom, same-level peer-assisted learning approach to clinical skill teaching for medical students by Chan, Enoch, Botelho, Michael George, Wong, Gordon Tin Chun

“…Clinical procedural skills are vital components of medical education. Increased student intake and limited capacity of medical schools necessitate more…”
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Adiponectin deficiency is a critical factor contributing to cognitive dysfunction in obese mice after sevoflurane exposure by Chu, John Man Tak, Chiu, Suki Pak Wing, Wang, Jiaqi, Chang, Raymond Chuen Chung, Wong, Gordon Tin Chun

“…The number of major operations performed in obese patients is expected to increase given the growing prevalence of obesity. Obesity is a risk factor for a…”
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Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice by Chen, Ying, Chu, John Man-Tak, Wong, Gordon Tin-Chun, Chang, Raymond Chuen-Chung

“…Aberrant activation of complement cascades plays an important role in the progress of neurological disorders. Complement C3, the central complement component,…”
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Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice by Huang, Chunxia, Ng, Olivia Tsz-Wa, Chu, John Man-Tak, Irwin, Michael Garnet, Hu, Xianwen, Zhu, Shoufeng, Chang, Raymond Chuen-Chung, Wong, Gordon Tin-Chun

“…•Systemic lipopolysaccharide (LPS) produces cognitive impairment, neuroinflammation and an increase in oxidative stress in the hippocampus.•Dexmedetomidine…”
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Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders by Liu, Yan, Chu, John Man Tak, Ran, You, Zhang, Yan, Chang, Raymond Chuen Chung, Wong, Gordon Tin Chun

“…Postoperative neurocognitive dysfunction remains a significant problem in vulnerable groups such as the elderly. While experimental data regarding its possible…”
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The Complement System in the Central Nervous System: From Neurodevelopment to Neurodegeneration by Chen, Ying, Chu, John Man Tak, Chang, Raymond Chuen Chung, Wong, Gordon Tin Chun

“…The functions of the complement system to both innate and adaptive immunity through opsonization, cell lysis, and inflammatory activities are well known. In…”
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Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far? by Zhang, Hong-Qi, Wong, Gordon Tin-Chun, Yeung, Wing-Fai, Zhao, Fei-Yi, Ho, Yuen-Shan, Chang, Raymond Chuen-Chung

“…Postoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important…”
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The role of PKC/PKR in aging, Alzheimer's disease, and perioperative neurocognitive disorders by Lu, Wenping, Tang, Sailan, Li, Ao, Huang, Qiuyue, Dou, Mengyun, Zhang, Ye, Hu, Xianwen, Chang, Raymond Chuen Chung, Wong, Gordon Tin Chun, Huang, Chunxia

“…Background The incidence of perioperative neurocognitive disorders (PNDs) is reportedly higher in older patients. Mitochondrial and synaptic dysfunctions have…”
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