Search Results - "Wong, Frederick C K"

Position-dependent plasticity of distinct progenitor types in the primitive streak by Wymeersch, Filip J, Huang, Yali, Blin, Guillaume, Cambray, Noemí, Wilkie, Ron, Wong, Frederick C K, Wilson, Valerie

“…The rostrocaudal (head-to-tail) axis is supplied by populations of progenitors at the caudal end of the embryo. Despite recent advances characterising one of…”
Get full text

Spatial multiomics map of trophoblast development in early pregnancy by Arutyunyan, Anna, Roberts, Kenny, Troulé, Kevin, Wong, Frederick C. K., Sheridan, Megan A., Kats, Ilia, Garcia-Alonso, Luz, Velten, Britta, Hoo, Regina, Ruiz-Morales, Elias R., Sancho-Serra, Carmen, Shilts, Jarrod, Handfield, Louis-Francois, Marconato, Luca, Tuck, Elizabeth, Gardner, Lucy, Mazzeo, Cecilia Icoresi, Li, Qian, Kelava, Iva, Wright, Gavin J., Prigmore, Elena, Teichmann, Sarah A., Bayraktar, Omer Ali, Moffett, Ashley, Stegle, Oliver, Turco, Margherita Y., Vento-Tormo, Roser

“…The relationship between the human placenta—the extraembryonic organ made by the fetus, and the decidua—the mucosal layer of the uterus, is essential to…”
Get full text

Human primordial germ cell-like cells specified from resetting precursors develop in human hindgut organoids by Alves-Lopes, João Pedro, Wong, Frederick C. K., Surani, M. Azim

“…Human primordial germ cells (hPGCs), the precursors of eggs and sperm, start their complex development shortly after specification and during their migration…”
Get full text

The unfolding body plan of primate embryos in culture by Neupane, Jitesh, Wong, Frederick C. K., Surani, M. Azim

Get full text

Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog by Karwacki-Neisius, Violetta, Göke, Jonathan, Osorno, Rodrigo, Halbritter, Florian, Ng, Jia Hui, Weiße, Andrea Y., Wong, Frederick C.K., Gagliardi, Alessia, Mullin, Nicholas P., Festuccia, Nicola, Colby, Douglas, Tomlinson, Simon R., Ng, Huck-Hui, Chambers, Ian

“…Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered on the transcription factors Oct4 and Nanog. To date, robust…”
Get full text

Epigenetic resetting in the human germ line entails histone modification remodeling by Gruhn, Wolfram H, Tang, Walfred W C, Dietmann, Sabine, Alves-Lopes, João P, Penfold, Christopher A, Wong, Frederick C K, Ramakrishna, Navin B, Surani, M Azim

“…Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which lays the foundation for gametogenesis, totipotency, and embryonic…”
Get full text

A patterned human neural tube model using microfluidic gradients by Xue, Xufeng, Kim, Yung Su, Ponce-Arias, Alfredo-Isaac, O’Laughlin, Richard, Yan, Robin Zhexuan, Kobayashi, Norio, Tshuva, Rami Yair, Tsai, Yu-Hwai, Sun, Shiyu, Zheng, Yi, Liu, Yue, Wong, Frederick C. K., Surani, Azim, Spence, Jason R., Song, Hongjun, Ming, Guo-Li, Reiner, Orly, Fu, Jianping

“…The human nervous system is a highly complex but organized organ. The foundation of its complexity and organization is laid down during regional patterning of…”
Get full text

Genetic basis for primordial germ cells specification in mouse and human: Conserved and divergent roles of PRDM and SOX transcription factors by Sybirna, Anastasiya, Wong, Frederick C K, Surani, M Azim

“…Primordial germ cells (PGCs) are embryonic precursors of sperm and egg that pass on genetic and epigenetic information from one generation to the next. In…”
Get full text

An integrated single-cell reference atlas of the human endometrium by Marečková, Magda, Garcia-Alonso, Luz, Moullet, Marie, Lorenzi, Valentina, Petryszak, Robert, Sancho-Serra, Carmen, Oszlanczi, Agnes, Icoresi Mazzeo, Cecilia, Wong, Frederick C. K., Kelava, Iva, Hoffman, Sophie, Krassowski, Michał, Garbutt, Kurtis, Gaitskell, Kezia, Yancheva, Slaveya, Woon, Ee Von, Male, Victoria, Granne, Ingrid, Hellner, Karin, Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Lotfollahi, Mohammad, Prigmore, Elena, Southcombe, Jennifer, Dragovic, Rebecca A., Becker, Christian M., Zondervan, Krina T., Vento-Tormo, Roser

“…The complex and dynamic cellular composition of the human endometrium remains poorly understood. Previous endometrial single-cell atlases profiled few donors…”
Get full text

Specification of human germ cell fate with enhanced progression capability supported by hindgut organoids by Alves-Lopes, João Pedro, Wong, Frederick C.K., Tang, Walfred W.C., Gruhn, Wolfram H., Ramakrishna, Navin B., Jowett, Geraldine M., Jahnukainen, Kirsi, Surani, M. Azim

“…Human primordial germ cells (hPGCs), the precursors of sperm and eggs, are specified during weeks 2−3 after fertilization. Few studies on ex vivo and in vitro…”
Get full text

G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst by Zylicz, Jan J, Borensztein, Maud, Wong, Frederick Ck, Huang, Yun, Lee, Caroline, Dietmann, Sabine, Surani, M Azim

“…Early mouse development is regulated and accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation…”
Get full text

Origin and segregation of the human germline by Castillo-Venzor, Aracely, Penfold, Christopher A, Morgan, Michael D, Tang, Walfred Wc, Kobayashi, Toshihiro, Wong, Frederick Ck, Bergmann, Sophie, Slatery, Erin, Boroviak, Thorsten E, Marioni, John C, Surani, M Azim

“…Human germline-soma segregation occurs during weeks 2-3 in gastrulating embryos. Although direct studies are hindered, here, we investigate the dynamics of…”
Get full text

Distinct SoxB1 networks are required for naïve and primed pluripotency by Corsinotti, Andrea, Wong, Frederick Ck, Tatar, Tülin, Szczerbinska, Iwona, Halbritter, Florian, Colby, Douglas, Gogolok, Sabine, Pantier, Raphaël, Liggat, Kirsten, Mirfazeli, Elham S, Hall-Ponsele, Elisa, Mullin, Nicholas P, Wilson, Valerie, Chambers, Ian

“…Deletion of from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related…”
Get full text

Whole-Mount Immunofluorescence Staining of Early Mouse Embryos by Wong, Frederick C K

“…Immunofluorescence staining enables the visualization of protein expression at a cellular or even sub-nuclear level. Whole-mount staining preserves the…”
Get more information

Testing the role of SOX15 in human primordial germ cell fate by Pierson Smela, Merrick, Sybirna, Anastasiya, Wong, Frederick C K, Surani, M Azim

“…Potentially novel regulators of early human germline development have been identified recently, including SOX15 and SOX17, both of which show specific…”
Get full text