Search Results - "Wong, Eric B."

B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers by Soni, Chetna, Wong, Eric B, Domeier, Phillip P, Khan, Tahsin N, Satoh, Takashi, Akira, Shizuo, Rahman, Ziaur S M

“…Spontaneous germinal center (Spt-GC) B cells and follicular helper T cells generate high-affinity autoantibodies that are involved in the development of…”
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Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection by Xu, Ren-Huan, Wong, Eric B., Rubio, Daniel, Roscoe, Felicia, Ma, Xueying, Nair, Savita, Remakus, Sanda, Schwendener, Reto, John, Shinu, Shlomchik, Mark, Sigal, Luis J.

“…Toll-like receptor 9 (TLR9), its adaptor MyD88, the downstream transcription factor interferon regulatory factor 7 (IRF7), and type I interferons (IFN-I) are…”
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Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy by Wong, Eric B, Montoya, Brian, Ferez, Maria, Stotesbury, Colby, Sigal, Luis J

“…Cells sensing infection produce Type I interferons (IFN-I) to stimulate Interferon Stimulated Genes (ISGs) that confer resistance to viruses. During…”
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Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing by Ferez, Maria, Knudson, Cory J, Lev, Avital, Wong, Eric B, Alves-Peixoto, Pedro, Tang, Lingjuan, Stotesbury, Colby, Sigal, Luis J

“…Natural killer (NK) cell activation depends on the signaling balance of activating and inhibitory receptors. CD94 forms inhibitory receptors with NKG2A and…”
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LNK/ SH2B3 as a novel driver in juvenile myelomonocytic leukemia by Wintering, Astrid, Hecht, Anna, Meyer, Julia, Wong, Eric B, Hübner, Juwita, Abelson, Sydney, Feldman, Kira, Kennedy, Vanessa E, Peretz, Cheryl A C, French, Deborah L, Maguire, Jean Ann, Jobaliya, Chintan, Vasquez, Marta Rojas, Desai, Sunil, Dulman, Robin, Nemecek, Eneida, Haines, Hilary, Hammad, Mahmoud, El Haddad, Alaa, Kogan, Scott C, Abdullaev, Zied, Chehab, Farid F, Tasian, Sarah K, Smith, Catherine C, Loh, Mignon L, Stieglitz, Elliot

“…Mutations in five canonical Ras pathway genes (NF1, NRAS, KRAS, PTPN11 and CBL) are detected in nearly 90% of patients with juvenile myelomonocytic leukemia…”
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B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance by Wong, Eric B, Soni, Chetna, Chan, Alice Y, Domeier, Phillip P, Shwetank, Abraham, Thomas, Limaye, Nisha, Khan, Tahsin N, Elias, Melinda J, Chodisetti, Sathi Babu, Wakeland, Edward K, Rahman, Ziaur S M

“…Signaling lymphocyte activation molecules (SLAMs) play an integral role in immune regulation. Polymorphisms in the SLAM family receptors are implicated in…”
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Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production by Khan, Tahsin N, Wong, Eric B, Soni, Chetna, Rahman, Ziaur S M

“…Mer receptor tyrosine kinase is a member of the Tyro-3/Axl/Mer (TAM) subfamily of receptor tyrosine kinases, and its expression on phagocytes facilitates their…”
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The lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner by Wong, Eric B, Khan, Tahsin N, Mohan, Chandra, Rahman, Ziaur S M

“…C57BL/6 (B6) mice carrying the Sle1b sublocus (named B6.Sle1b), which harbors the lupus-associated NZM2410/NZW SLAM family genes, produce antinuclear Abs…”
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IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity by Domeier, Phillip P, Chodisetti, Sathi Babu, Soni, Chetna, Schell, Stephanie L, Elias, Melinda J, Wong, Eric B, Cooper, Timothy K, Kitamura, Daisuke, Rahman, Ziaur S M

“…Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that generate somatically mutated and class-switched pathogenic…”
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CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window by Halperin, Shakked O., Tou, Connor J., Wong, Eric B., Modavi, Cyrus, Schaffer, David V., Dueber, John E.

“…The capacity to diversify genetic codes advances our ability to understand and engineer biological systems 1 , 2 . A method for continuously diversifying…”
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Chronic Lymphocytic Choriomeningitis Infection Causes Susceptibility to Mousepox and Impairs Natural Killer Cell Maturation and Function by Alves-Peixoto, Pedro, Férez, Maria, Knudson, Cory J, Stotesbury, Colby, Melo-Silva, Carolina R, Wong, Eric B, Correia-Neves, Margarida, Sigal, Luis J

“…Chronic viral infections. like those of humans with cytomegalovirus, human immunodeficiency virus (even when under antiretroviral therapy), and hepatitis C…”
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Loss of Resistance to Mousepox during Chronic Lymphocytic Choriomeningitis Virus Infection Is Associated with Impaired T-Cell Responses and Can Be Rescued by Immunization by Alves-Peixoto, Pedro, Férez, Maria, Knudson, Cory J, Melo-Silva, Carolina R, Stotesbury, Colby, Wong, Eric B, Correia-Neves, Margarida, Sigal, Luis J

“…It is well established that chronic viral infections can cause immune suppression, resulting in increased susceptibility to other infectious diseases. However,…”
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Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation by Stotesbury, Colby, Wong, Eric B., Tang, Lingjuan, Montoya, Brian, Knudson, Cory J., Melo‐Silva, Carolina R., Sigal, Luis J.

“…It is known that aging decreases natural resistance to viral diseases due to dysfunctional innate and adaptive immune responses, but the nature of these…”
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Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4 by Wong, Eric B, Mallet, Jean-François, Duarte, Jairo, Matar, Chantal, Ritz, Barry W

“…Abstract Oral administration of bovine colostrum affects intestinal immunity, including an increased percentage of natural killer (NK) cells. However, effects…”
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Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity by Soni, Chetna, Domeier, Phillip P, Wong, Eric B, Shwetank, Khan, Tahsin N, Elias, Melinda J, Schell, Stephanie L, Lukacher, Aron E, Cooper, Timothy K, Rahman, Ziaur S.M

“…Abstract The inhibitory IgG Fc receptor (FcγRIIB) deficiency and 129 strain-derived signaling lymphocyte activation molecules (129-SLAMs) are proposed to…”
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Allosteric SHP2 Inhibitor RMC4550 Synergizes with Venetoclax in FLT3 and KIT Mutant Acute Myeloid Leukemia by Popescu, Bogdan, Stahlhut, Carlos, Tarver, Theodore C., Ferng, Timothy T., Peretz, Cheryl, Wishner, Sydney, Phojanakong, Paul, Steri, Veronica, Wong, Eric B., Rivera, Jose M., Stieglitz, Elliot, Smith, Catherine C.

“…Mutations in receptor tyrosine kinases (RTK) FLT3 and KIT occur frequently in Acute Myeloid Leukemia (AML) and are associated with high risk of relapse. FLT3…”
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Supplementation with bovine colostrum enhances natural killer cell activity in influenza‐infected mice by Wong, Eric B, Ritz, Barry W

“…Bovine colostrum (BC), from the first milking following partuition, is available as a human nutraceutical for immune support, although data are limited. Oral…”
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Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ helper T cell responses leading to autoantibody production by Khan, Tahsin N., Wong, Eric B., Soni, Chetna, Rahman, Ziaur S.M.

“…Mer (MerTK) is a member of the Tyro-3/Axl/Mer (TAM) subfamily of receptor tyrosine kinases and its expression on phagocytes facilitates their clearance of…”
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The lupus-prone NZM2410/NZW strain derived Sle1b sub-locus alters the germinal center checkpoint in female mice in a B cell intrinsic manner by Wong, Eric B., Khan, Tahsin N., Mohan, Chandra, Rahman, Ziaur S.M.

“…C57BL/6 (B6) mice carrying the Sle1b sub-locus (named B6. Sle1b ), which harbors the lupus-associated NZM2410/NZW SLAM family genes, produce anti-nuclear…”
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The role of SLAM family receptors in germinal center-mediated autoimmunity by Wong, Eric B

“…Systemic lupus erythematosus (SLE) is a complex, polygenic autoimmune disease that exhibits a high female gender bias and possesses a highly heterogeneous…”
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