Search Results - "Wong, Edwin"

Diseases of complement dysregulation—an overview by Wong, Edwin K. S., Kavanagh, David

“…Atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy (C3G), and paroxysmal nocturnal hemoglobinuria (PNH) are prototypical disorders of complement…”
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Hemolytic Uremic Syndrome in Pregnancy and Postpartum by Bruel, Alexandra, Kavanagh, David, Noris, Marina, Delmas, Yahsou, Wong, Edwin K S, Bresin, Elena, Provôt, François, Brocklebank, Vicky, Mele, Caterina, Remuzzi, Giuseppe, Loirat, Chantal, Frémeaux-Bacchi, Véronique, Fakhouri, Fadi

“…Pregnancy is associated with various forms of thrombotic microangiopathy, including hemolytic uremic syndrome. A previous small French study suggested that…”
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Complement therapy in atypical haemolytic uraemic syndrome (aHUS) by Wong, Edwin K.S., Goodship, Tim H.J., Kavanagh, David

“…Central to the pathogenesis of atypical haemolytic uraemic syndrome (aHUS) is over-activation of the alternative pathway of complement. Inherited defects in…”
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Disability and Place of Death in Older Americans: The Moderating Role of Household Wealth by Im, Jennifer, Abedini, Nauzley C., Wong, Edwin S.

“…Home-based deaths are increasing, yet, how wealth influences where people die in the presence of disability remains unknown. To examine place of death by help…”
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Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome by Wong, Edwin K.S, Kavanagh, David

“…The complement inhibitor eculizumab is a humanized monoclonal antibody against C5. It was developed to specifically target cleavage of C5 thus preventing…”
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Prospective Study of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma on Waitlist for Liver Transplant by Wong, Tiffany Cho‐Lam, Lee, Victor Ho‐Fun, Law, Ada Lai‐Yau, Pang, Herbert H., Lam, Ka‐On, Lau, Vince, Cui, Tracy Yushi, Fong, Adrianna Sze‐Yin, Lee, Sarah Wai‐Man, Wong, Edwin Chun‐Yin, Dai, Jeff Wing‐Chiu, Chan, Albert Chi‐Yan, Cheung, Tan‐To, Fung, James Yan‐Yue, Yeung, Rebecca Mei‐Wan, Luk, Mai‐Yee, Leung, To‐Wai, Lo, Chung‐Mau

“…Background and Aims There are no prospective data on stereotactic body radiation therapy (SBRT) as a bridge to liver transplantation for HCC. This study aimed…”
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Impact of Home Telehealth Expansion on High-Cost Utilization Among Veterans Health Administration Patients with Diabetes by Reddy, Ashok, Gunnink, Eric J, Rojas, Jorge, Nelson, Karin, Wong, Edwin S

“…Home telehealth (HT) services have rapidly expanded in the Veterans Health Administration (VHA), but little is known about the real-world impact of the…”
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Large-Scale Whole-Genome Sequencing Reveals the Genetic Architecture of Primary Membranoproliferative GN and C3 Glomerulopathy by Levine, Adam P, Chan, Melanie M Y, Sadeghi-Alavijeh, Omid, Wong, Edwin K S, Cook, H Terence, Ashford, Sofie, Carss, Keren, Christian, Martin T, Hall, Matthew, Harris, Claire Louise, McAlinden, Paul, Marchbank, Kevin J, Marks, Stephen D, Maxwell, Heather, Megy, Karyn, Penkett, Christopher J, Mozere, Monika, Stirrups, Kathleen E, Tuna, Salih, Wessels, Julie, Whitehorn, Deborah, Johnson, Sally A, Gale, Daniel P

“…Primary membranoproliferative GN, including complement 3 (C3) glomerulopathy, is a rare, untreatable kidney disease characterized by glomerular complement…”
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Patient Enrollment Growth and Burnout in Primary Care at the Veterans Health Administration by O’Connor, Allyson W., Wong, Edwin S., Nelson, Karin M., Sears, Jeanne M., Helfrich, Christian D.

“…Background Patient enrollment levels at Veterans Health Administration (VHA) facilities change based on Veteran demand for care, potentially affecting demands…”
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“Low-value” glycemic outcomes among older adults with diabetes cared for by primary care nurse practitioners or physicians: A retrospective cohort study by Schuttner, Linnaea, Richardson, Claire, Parikh, Toral, Wong, Edwin S.

“…“Low-value” healthcare is care without benefit to patients. Overly intensive glycemic control (i.e., HgbA1C < 7 %) can cause harm to patients at high risk of…”
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Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration by Yu, Yi, Triebwasser, Michael P, Wong, Edwin K S, Schramm, Elizabeth C, Thomas, Brett, Reynolds, Robyn, Mardis, Elaine R, Atkinson, John P, Daly, Mark, Raychaudhuri, Soumya, Kavanagh, David, Seddon, Johanna M

“…We sequenced the whole exome of 35 cases and 7 controls from 9 age-related macular degeneration (AMD) families in whom known common genetic risk alleles could…”
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Long-term outcomes and response to treatment in diacylglycerol kinase epsilon nephropathy by Brocklebank, Vicky, Kumar, Gurinder, Howie, Alexander J, Chandar, Jayanthi, Milford, David V, Craze, Janet, Evans, Jonathan, Finlay, Eric, Freundlich, Michael, Gale, Daniel P, Inward, Carol, Mraz, Martin, Jones, Caroline, Wong, William, Marks, Stephen D, Connolly, John, Corner, Bronte M, Smith-Jackson, Kate, Walsh, Patrick R, Marchbank, Kevin J, Harris, Claire L, Wilson, Valerie, Wong, Edwin K S, Malina, Michal, Johnson, Sally, Sheerin, Neil S, Kavanagh, David

“…Recessive mutations in diacylglycerol kinase epsilon (DGKE) display genetic pleiotropy, with pathological features reported as either thrombotic…”
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Identifying Patterns of Primary Care In-Person and Telemedicine Use in the Veterans Health Administration: A Latent Class Analysis by Staloff, Jonathan, Gunnink, Eric, Rojas, Jorge, Wong, Edwin S., Nelson, Karin, Reddy, Ashok

“…Background The Veterans Health Administration increased synchronous telemedicine (video and telephone visits) in primary care in response to the COVID-19…”
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Does machine learning improve prediction of VA primary care reliance? by Wong, Edwin S, Schuttner, Linnaea, Reddy, Ashok

“…The Veterans Affairs (VA) Health Care System is among the largest integrated health systems in the United States. Many VA enrollees are dual users of Medicare,…”
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Pyridine Analogues of the Antimetastatic Ru(III) Complex NAMI-A Targeting Non-Covalent Interactions with Albumin by Webb, Michael I, Chard, Ryan A, Al-Jobory, Yaser M, Jones, Michael R, Wong, Edwin W. Y, Walsby, Charles J

“…A series of pyridine-based derivatives of the antimetastatic Ru(III) complex imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)] (NAMI-A) have been synthesized…”
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Potential pitfalls in incorporating plasma Epstein‐Barr virus DNA in the management of nasopharyngeal carcinoma by Wong, Edwin C. Y., Hung, Jessica L. C., Ng, Wai T.

“…Background This study identifies potential pitfalls in incorporating plasma Epstein‐Barr virus (EBV) DNA into the management of nasopharyngeal carcinoma (NPC)…”
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Phthalocyanine as a Chemically Inert, Redox-Active Ligand: Structural and Electronic Properties of a Nb(IV)-Oxo Complex Incorporating a Highly Reduced Phthalocyanine(4−) Anion by Wong, Edwin W. Y, Walsby, Charles J, Storr, Tim, Leznoff, Daniel B

“…This report describes the reduction of a niobium(V) phthalocyanine complex and investigation of the electronic structure of the resulting products. The…”
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National Burnout Trends Among Physicians Working in the Department of Veterans Affairs by Rinne, Seppo T., Mohr, David C., Swamy, Lakshman, Blok, Amanda C., Wong, Edwin S., Charns, Martin P.

“…Background Heterogeneity of existing physician burnout studies impairs analyses of longitudinal trends, geographic distribution, and organizational factors…”
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Thrombotic Microangiopathy in Inverted Formin 2 - Mediated Renal Disease by Challis, Rachel C, Ring, Troels, Xu, Yaobo, Wong, Edwin K S, Flossmann, Oliver, Roberts, Ian S D, Ahmed, Saeed, Wetherall, Michael, Salkus, Giedrius, Brocklebank, Vicky, Fester, Julian, Strain, Lisa, Wilson, Valerie, Wood, Katrina M, Marchbank, Kevin J, Santibanez-Koref, Mauro, Goodship, Timothy H J, Kavanagh, David

“…The demonstration of impaired C regulation in the thrombotic microangiopathy (TMA) atypical hemolytic uremic syndrome (aHUS) resulted in the successful…”
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Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland by Brocklebank, Vicky, Johnson, Sally, Sheerin, Thomas P, Marks, Stephen D, Gilbert, Rodney D, Tyerman, Kay, Kinoshita, Meredith, Awan, Atif, Kaur, Amrit, Webb, Nicholas, Hegde, Shivaram, Finlay, Eric, Fitzpatrick, Maggie, Walsh, Patrick R, Wong, Edwin K S, Booth, Caroline, Kerecuk, Larissa, Salama, Alan D, Almond, Mike, Inward, Carol, Goodship, Timothy H, Sheerin, Neil S, Marchbank, Kevin J, Kavanagh, David

“…Factor H autoantibodies can impair complement regulation, resulting in atypical hemolytic uremic syndrome, predominantly in childhood. There are no trials…”
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