Search Results - "Wong, Dean F."

Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition by Gottesman, Rebecca F, Schneider, Andrea L. C, Zhou, Yun, Coresh, Josef, Green, Edward, Gupta, Naresh, Knopman, David S, Mintz, Akiva, Rahmim, Arman, Sharrett, A. Richey, Wagenknecht, Lynne E, Wong, Dean F, Mosley, Thomas H

“…IMPORTANCE: Midlife vascular risk factors have been associated with late-life dementia. Whether these risk factors directly contribute to brain amyloid…”
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Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults by Bilgel, Murat, An, Yang, Helphrey, Jessica, Elkins, Wendy, Gomez, Gabriela, Wong, Dean F, Davatzikos, Christos, Ferrucci, Luigi, Resnick, Susan M

“…See Gonneaud and Chételat (doi:10.1093/brain/awy174) for a scientific commentary on this article. Bilgel et al. examine the distinct and synergistic effects of…”
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Four decades of mapping and quantifying neuroreceptors at work in vivo by positron emission tomography by Gjedde, Albert, Wong, Dean F

“…Decryption of brain images is the basis for the necessary translation of the findings from imaging to information required to meet the demands of clinical…”
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Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging by Bilgel, Murat, Beason-Held, Lori, An, Yang, Zhou, Yun, Wong, Dean F, Resnick, Susan M

“…Surrogates of neuronal activity, typically measured by regional cerebral blood flow (rCBF) or glucose metabolism, can be estimated from dynamic amyloid PET…”
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The Role of Imaging in Proof of Concept for CNS Drug Discovery and Development by Wong, Dean F, Tauscher, Johannes, Gründer, Gerhard

“…Neuroimaging, particularly that of neuroreceptor radioisotope and functional magnetic resonance imaging (fMRI), has played a fundamental role in…”
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The Role of Dopamine in Value-Based Attentional Orienting by Anderson, Brian A., Kuwabara, Hiroto, Wong, Dean F., Gean, Emily G., Rahmim, Arman, Brašić, James R., George, Noble, Frolov, Boris, Courtney, Susan M., Yantis, Steven

“…Reward learning gives rise to strong attentional biases. Stimuli previously associated with reward automatically capture visual attention regardless of…”
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study by Varma, Vijay R, Wang, Youjin, An, Yang, Varma, Sudhir, Bilgel, Murat, Doshi, Jimit, Legido-Quigley, Cristina, Delgado, João C, Oommen, Anup M, Roberts, Jackson A, Wong, Dean F, Davatzikos, Christos, Resnick, Susan M, Troncoso, Juan C, Pletnikova, Olga, O'Brien, Richard, Hak, Eelko, Baak, Brenda N, Pfeiffer, Ruth, Baloni, Priyanka, Mohmoudiandehkordi, Siamak, Nho, Kwangsik, Kaddurah-Daouk, Rima, Bennett, David A, Gadalla, Shahinaz M, Thambisetty, Madhav

“…While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We…”
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Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study by Anderson, Brian A., Kuwabara, Hiroto, Wong, Dean F., Roberts, Joshua, Rahmim, Arman, Brašić, James R., Courtney, Susan M.

“…The attention system is shaped by reward history, such that learned reward cues involuntarily draw attention. Recent research has begun to uncover the neural…”
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Relative Strengths of Three Linearizations of Receptor Availability: Saturation, Inhibition, and Occupancy Plots by Khodaii, Javad, Araj-Khodaei, Mostafa, Vafaee, Manouchehr S, Wong, Dean F, Gjedde, Albert

“…We derived three widely used linearizations from the definition of receptor availability in molecular imaging with positron emission tomography (PET). The…”
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Molecular imaging of serotonin degeneration in mild cognitive impairment by Smith, Gwenn S, Barrett, Frederick S, Joo, Jin Hui, Nassery, Najlla, Savonenko, Alena, Sodums, Devin J, Marano, Christopher M, Munro, Cynthia A, Brandt, Jason, Kraut, Michael A, Zhou, Yun, Wong, Dean F, Workman, Clifford I

“…Abstract Neuropathological and neuroimaging studies have consistently demonstrated degeneration of monoamine systems, especially the serotonin system, in…”
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Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging by Thambisetty, Madhav, Jeffrey Metter, E, Yang, An, Dolan, Hillary, Marano, Christopher, Zonderman, Alan B, Troncoso, Juan C, Zhou, Yun, Wong, Dean F, Ferrucci, Luigi, Egan, Josephine, Resnick, Susan M, O'Brien, Richard J

“…Peripheral glucose homeostasis has been implicated in the pathogenesis of Alzheimer disease (AD). The relationship among diabetes mellitus, insulin, and AD is…”
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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands by Innis, Robert B, Cunningham, Vincent J, Delforge, Jacques, Fujita, Masahiro, Gjedde, Albert, Gunn, Roger N, Holden, James, Houle, Sylvain, Huang, Sung-Cheng, Ichise, Masanori, Iida, Hidehiro, Ito, Hiroshi, Kimura, Yuichi, Koeppe, Robert A, Knudsen, Gitte M, Knuuti, Juhani, Lammertsma, Adriaan A, Laruelle, Marc, Logan, Jean, Maguire, Ralph Paul, Mintun, Mark A, Morris, Evan D, Parsey, Ramin, Price, Julie C, Slifstein, Mark, Sossi, Vesna, Suhara, Tetsuya, Votaw, John R, Wong, Dean F, Carson, Richard E

“…An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding…”
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Individual estimates of age at detectable amyloid onset for risk factor assessment by Bilgel, Murat, An, Yang, Zhou, Yun, Wong, Dean F, Prince, Jerry L, Ferrucci, Luigi, Resnick, Susan M

“…Abstract Introduction Individualized estimates of age at detectable amyloid-beta (Aβ) accumulation, distinct from amyloid positivity, allow for analysis of…”
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An open-label, positron emission tomography study of the striatal D2/D3 receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants by Wong, Dean F., Raoufinia, Arash, Bricmont, Patricia, Brašić, James R., McQuade, Robert D., Forbes, Robert A., Kikuchi, Tetsuro, Kuwabara, Hiroto

“…Purpose The aim of this Phase 1, open-label, positron emission tomography (PET) study was to determine the degree of striatal D 2 /D 3 receptor occupancy…”
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Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor by Moldovan, Rareş-Petru, Teodoro, Rodrigo, Gao, Yongjun, Deuther-Conrad, Winnie, Kranz, Mathias, Wang, Yuchuan, Kuwabara, Hiroto, Nakano, Masayoshi, Valentine, Heather, Fischer, Steffen, Pomper, Martin G, Wong, Dean F, Dannals, Robert F, Brust, Peter, Horti, Andrew G

“…Cannabinoid receptors type 2 (CB2) represent a target with increasing importance for neuroimaging due to its upregulation under various pathological…”
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The association of long-term exposure to criteria air pollutants, fine particulate matter components, and airborne trace metals with late-life brain amyloid burden in the Atherosclerosis Risk in Communities (ARIC) study by Bennett, Erin E., Song, Ziwei, Lynch, Katie M., Liu, Chelsea, Stapp, Emma K., Xu, Xiaohui, Park, Eun Sug, Ying, Qi, Smith, Richard L., Stewart, James D., Whitsel, Eric A., Mosley, Thomas H., Wong, Dean F., Liao, Duanping, Yanosky, Jeff D., Szpiro, Adam A., Kaufman, Joel D., Gottesman, Rebecca F., Power, Melinda C.

“…[Display omitted] Studies suggest associations between long-term ambient air pollution exposure and outcomes related to Alzheimer’s disease (AD). Whether a…”
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The prospective association between periodontal disease and brain imaging outcomes: The Atherosclerosis Risk in Communities study by Adam, Hamdi S., Lakshminarayan, Kamakshi, Wang, Wendy, Norby, Faye L., Mosley, Thomas, Walker, Keenan A., Gottesman, Rebecca F., Meyer, Katie, Hughes, Timothy M., Pankow, James S., Wong, Dean F., Jack, Clifford R., Sen, Souvik, Lutsey, Pamela L., Beck, Jim, Demmer, Ryan T.

“…Aim We investigate if periodontal disease is prospectively associated with cerebrovascular and neurodegenerative markers of dementia and Alzheimer's pathology…”
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Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome: A Pilot Study by Brašić, James Robert, Nandi, Ayon, Russell, David S, Jennings, Danna, Barret, Olivier, Martin, Samuel D, Slifer, Keith, Sedlak, Thomas, Seibyl, John P, Wong, Dean F, Budimirovic, Dejan B

“…Multiple lines of evidence suggest that dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR ) plays a role in the pathogenesis of autism…”
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Milkshake Acutely Stimulates Dopamine Release in Ventral and Dorsal Striatum in Healthy-Weight Individuals and Patients with Severe Obesity Undergoing Bariatric Surgery: A Pilot Study by Carnell, Susan, Steele, Kimberley E, Thapaliya, Gita, Kuwubara, Hiroto, Aghababian, Anahys, Papantoni, Afroditi, Nandi, Ayon, Brašić, James R, Moran, Timothy H, Wong, Dean F

“…The overconsumption of palatable energy-dense foods drives obesity, but few human studies have investigated dopamine (DA) release in response to the…”
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Sex Differences in Striatal Dopamine Release in Healthy Adults by Munro, Cynthia A., McCaul, Mary E., Wong, Dean F., Oswald, Lynn M., Zhou, Yun, Brasic, James, Kuwabara, Hiroto, Kumar, Anil, Alexander, Mohab, Ye, Weiguo, Wand, Gary S.

“…Sex differences in addictive disorders have been described. Preclinical studies have implicated the striatal dopamine system in these differences, but human…”
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