Search Results - "Wong, Darren H"

Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases by GUISE, Theresa A, MOHAMMAD, Khalid S, CHIRGWIN, John M, CLINES, Gregory, STEBBINS, Elizabeth G, WONG, Darren H, HIGGINS, Linda S, VESSELLA, Robert, COREY, Eva, PADALECKI, Susan, SUVA, Larry

“…Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and…”
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Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone by Mohammad, Khalid S, Chen, Carol G, Balooch, Guive, Stebbins, Elizabeth, McKenna, C Ryan, Davis, Holly, Niewolna, Maria, Peng, Xiang Hong, Nguyen, Daniel H N, Ionova-Martin, Sophi S, Bracey, John W, Hogue, William R, Wong, Darren H, Ritchie, Robert O, Suva, Larry J, Derynck, Rik, Guise, Theresa A, Alliston, Tamara

“…During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these,…”
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Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo by Dudek, Henryk, Wong, Darren H, Arvan, Rokhand, Shah, Anee, Wortham, Kathleen, Ying, Bo, Diwanji, Rohan, Zhou, Wei, Holmes, Benjamin, Yang, Hailin, Cyr, Wendy A, Zhou, Yi, Shah, Aalok, Farkiwala, Ruchir, Lee, Michael, Li, Yiting, Rettig, Garrett R, Collingwood, Michael A, Basu, Sujit K, Behlke, Mark A, Brown, Bob D

“…Despite progress in identifying molecular drivers of cancer, it has been difficult to translate this knowledge into new therapies, because many of the causal…”
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SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo by UHL, Martin, AULWURM, Steffen, MURPHY, Alison, WONG, Darren H, WICK, Wolfgang, HIGGINS, Linda S, WELLER, Michael, WISCHHUSEN, Jörg, WEILER, Markus, JING YING MA, ALMIREZ, Ramona, MANGADU, Ruban, LIU, Yu-Wang, PLATTEN, Michael, HERRLINGER, Ulrich

“…The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the…”
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Temozolomide analogs with improved brain/plasma ratios – Exploring the possibility of enhancing the therapeutic index of temozolomide by Rai, Roopa, Banerjee, Monali, Wong, Darren H., McCullagh, Emma, Gupta, Ashu, Tripathi, Shailendra, Riquelme, Eduardo, Jangir, Ramnivas, Yadav, Shyamraj, Raja, Mohd, Melkani, Pankaj, Dixit, Vikas, Patil, Umesh, Shrivastava, Ritesh, Middya, Sandip, Olivares, Felipe, Guerrero, Javier, Surya, Arjun, Pham, Son M., Bernales, Sebastián, Protter, Andrew A., Hung, David T., Chakravarty, Sarvajit

“…[Display omitted] Temozolomide is a chemotherapeutic agent that is used in the treatment of glioblastoma and other malignant gliomas. It acts through DNA…”
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Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness by Gaspar, Nicholas J, Li, Lingyun, Kapoun, Ann M, Medicherla, Satyanarayana, Reddy, Mamatha, Li, Georgia, O'Young, Gilbert, Quon, Diana, Henson, Margaret, Damm, Deborah L, Muiru, Gladys T, Murphy, Alison, Higgins, Linda S, Chakravarty, Sarvajit, Wong, Darren H

“…Transforming growth factor beta (TGFbeta) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and immune suppression…”
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Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model by Tran, Thomas-Toan, Uhl, Martin, Ma, Jing Ying, Janssen, Lisa, Sriram, Venkataraman, Aulwurm, Steffen, Kerr, Irene, Lam, Andrew, Webb, Heather K, Kapoun, Ann M, Kizer, Darin E, McEnroe, Glenn, Hart, Barry, Axon, Jonathan, Murphy, Alison, Chakravarty, Sarvajit, Dugar, Sundeep, Protter, Andrew A, Higgins, Linda S, Wick, Wolfgang, Weller, Michael, Wong, Darren H

“…Transforming growth factor-beta (TGF-beta) is a proinvasive and immunosuppressive cytokine that plays a major role in the malignant phenotype of gliomas. One…”
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Antitumor Activity of TGF-β Inhibitor is Dependent on the Microenvironment by MEDICHERLA, Satyanarayana, LINGYUN LI, WONG, Darren H, HIGGINS, Linda S, JING YING MA, KAPOUN, Ann M, GASPAR, Nicholas J, LIU, Yu-Wang, MANGADU, Ruban, O'YOUNG, Gilbert, PROTTER, Andrew A, SCHREINER, George F

“…Pancreatic cancer is one of the deadliest forms of cancer and effective treatment remains a clinical challenge. Transforming growth factor-beta (TGF-beta) has…”
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Biochemical Studies of Zmpste24-deficient Mice by Leung, G K, Schmidt, W K, Bergo, M O, Gavino, B, Wong, D H, Tam, A, Ashby, M N, Michaelis, S, Young, S G

“…Genetic studies in Saccharomyces cerevisiae identified two genes, STE24 and RCE1 , involved in cleaving the three carboxyl-terminal amino acids from…”
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Studies with Recombinant Saccharomyces cerevisiae CaaX Prenyl Protease Rce1p by Dolence, Julia M, Steward, Lance E, Dolence, E. Kurt, Wong, Darren H, Poulter, C. Dale

“…Eukaryotic proteins with carboxyl-terminal CaaX motifs undergo three post-translational processing reactionsprotein prenylation, endoproteolysis, and…”
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Dynamic localization of the nuclear import receptor and its interactions with transport factors by Koepp, D.M. (Dana Farber Cancer Institute, Boston, MA.), Wong, D.H, Corbett, A.H, Silver, P.A

“…Characterization of the interactions between soluble factors required for nuclear transport is key to understanding the process of nuclear trafficking. Using a…”
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Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport by Wong, Darren H., Corbett, Anita H., Kent, Helen M., Stewart, Murray, Silver, Pamela A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors by Rydzewski, Robert M, Bryant, Clifford, Oballa, Renata, Wesolowski, Gregg, Rodan, Sevgi B, Bass, Kathryn E, Wong, Darren H

“…1-Cyanopyrrolidines have previously been reported to inhibit cysteinyl cathepsins (Falgueyret, J.-P. et al., J. Med. Chem. 2001, 44, 94). In order to optimize…”
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100-kD Proteins of Golgi- and Trans-Golgi Network-Associated Coated Vesicles Have Related but Distinct Membrane Binding Properties by Wong, Darren H., Brodsky, Frances M.

“…The 100-110-kD proteins (α, β-, β′-, and γ-adaptins) of clathrin-coated vesicles and the 110-kD protein (β-COP) of the nonclathrin-coated vesicles that mediate…”
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Knockdown of [beta]-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo by Dudek, Henryk, Wong, Darren H, Arvan, Rokhand, Shah, Anee, Wortham, Kathleen, Ying, Bo, Diwanji, Rohan, Zhou, Wei, Holmes, Benjamin, Yang, Hailin, Cyr, Wendy A, Zhou, Yi, Shah, Aalok, Farkiwala, Ruchir, Lee, Michael, Li, Yiting, Rettig, Garrett R, Collingwood, Michael A, Basu, Sujit K, Behlke, Mark A, Brown, Bob D

“…Despite progress in identifying molecular drivers of cancer, it has been difficult to translate this knowledge into new therapies, because many of the causal…”
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Pharmacologic Inhibition of the TGF-[beta] Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone by Mohammad, Khalid S, Chen, Carol G, Balooch, Guive, Stebbins, Elizabeth, McKenna, C. Ryan, Davis, Holly, Niewolna, Maria, Peng, Xiang Hong, Nguyen, Daniel H. N, Ionova-Martin, Sophi S, Bracey, John W, Hogue, William R, Wong, Darren H, Ritchie, Robert O, Suva, Larry J, Derynck, Rik, Guise, Theresa A, Alliston, Tamara

“…During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these,…”
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Mutants in a yeast Ran binding protein are defective in nuclear transport by Schlenstedt, G., Wong, D. H., Koepp, D. M., Silver, P. A.

“…Ran, a Ras‐like GTPase, has been implicated in controlling the movement of proteins and RNAs in and out of the nucleus. We have constructed strains of…”
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Pharmacologic Inhibition of the TGF-I2 Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone by Mohammad, Khalid S, Chen, Carol G, Balooch, Guive, Stebbins, Elizabeth, McKenna, CRyan, Davis, Holly, Niewolna, Maria, Peng, Xiang Hong, Nguyen, Daniel HN, Ionova-Martin, Sophi S, Bracey, John W, Hogue, William R, Wong, Darren H, Ritchie, Robert O, Suva, Larry J, Derynck, Rik, Guise, Theresa A, Alliston, Tamara, Calbet, Jose AL

“…During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these,…”
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Antitumor Activity of TGF-β, Inhibitor is Dependent on the Microenvironment by SATYANARAYANA MEDICHERLA, LINGYUN LI, JING YING MA, ANN M. KAPOUN, NICHOLAS J. GASPAR, YU-WANG LIU, RUBAN MANGADU, GILBERT O'YOUNG, ANDREW A. PROTTER, GEORGE F. SCHREINER, DARREN H. WONG, LINDA S. HIGGINS

“…Pancreatic cancer is one of the deadliest forms of cancer and effective treatment remains a clinical challenge. Transforming growth factor-beta (TGF-β) has…”
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Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics by Brodsky, F M, Hill, B L, Acton, S L, Näthke, I, Wong, D H, Ponnambalam, S, Parham, P

“…Polymerization of clathrin triskelions into clathrin coats and subsequent disassembly by the heat shock protein hsc70 control receptor-mediated pathways of…”
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