Search Results - "Wong, Christina S"

Optimized exosome isolation protocol for cell culture supernatant and human plasma by Lobb, Richard J., Becker, Melanie, Wen Wen, Shu, Wong, Christina S. F., Wiegmans, Adrian P., Leimgruber, Antoine, Möller, Andreas

“…Extracellular vesicles represent a rich source of novel biomarkers in the diagnosis and prognosis of disease. However, there is currently limited information…”
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NLRP3 Suppresses NK Cell―Mediated Responses to Carcinogen-Induced Tumors and Metastases by CHOW, Melvyn T, SCENEAY, Jaclyn, PAGET, Christophe, WONG, Christina S. F, DURET, Helene, TSCHOPP, Jurg, MÖLLER, Andreas, SMYTH, Mark J

“…The NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response upon infectious insults or tissue injury and…”
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Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche by SCENEAY, Jaclyn, CHOW, Melvyn T, MÖLLER, Andreas, CHEW, Anna, HALSE, Heloise M, WONG, Christina S. F, ANDREWS, Daniel M, SLOAN, Erica K, PARKER, Belinda S, BOWTELL, David D, SMYTH, Mark J

“…Hypoxia within a tumor acts as a strong selective pressure that promotes angiogenesis, invasion, and metastatic spread. In this study, we used immune competent…”
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Fractional 1064 nm Picosecond Laser in Treatment of Melasma and Skin Rejuvenation in Asians, A Prospective Study by Wong, Christina S. M, Chan, Mandy W. M, Shek, Samantha Y. N, Yeung, Chi Keung, Chan, Henry H. L

“…Background and Objectives Facial melasma is a disfiguring pigmentation and occurs frequently with aging skin. Topical treatment alone was often suboptimal. A…”
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The Biodistribution and Immune Suppressive Effects of Breast Cancer-Derived Exosomes by Wen, Shu Wen, Sceneay, Jaclyn, Lima, Luize Goncalves, Wong, Christina S F, Becker, Melanie, Krumeich, Sophie, Lobb, Richard J, Castillo, Vanessa, Wong, Ke Ni, Ellis, Sarah, Parker, Belinda S, Möller, Andreas

“…Small membranous secretions from tumor cells, termed exosomes, contribute significantly to intercellular communication and subsequent reprogramming of the…”
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Siah: A Promising Anticancer Target by WONG, Christina S. F, MÖLLER, Andreas

“…Siah ubiquitin ligases play important roles in a number of signaling pathways involved in the progression and spread of cancer in cell-based models, but their…”
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Tracking the fate of adoptively transferred myeloid-derived suppressor cells in the primary breast tumor microenvironment by Sceneay, Jaclyn, Griessinger, Christoph M, Hoffmann, Sabrina H L, Wen, Shu Wen, Wong, Christina S F, Krumeich, Sophie, Kneilling, Manfred, Pichler, Bernd J, Möller, Andreas

“…Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid progenitor cells that are expanded in cancer and act as potent…”
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The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo by Sceneay, Jaclyn, Liu, Mira C P, Chen, Anna, Wong, Christina S F, Bowtell, David D L, Möller, Andreas

“…Intratumoral hypoxia is a poor prognostic factor associated with reduced disease-free survival in many cancer types, including breast cancer. Hypoxia…”
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Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer by Rautela, Jai, Baschuk, Nikola, Slaney, Clare Y, Jayatilleke, Krishnath M, Xiao, Kun, Bidwell, Bradley N, Lucas, Erin C, Hawkins, Edwin D, Lock, Peter, Wong, Christina S, Chen, Weisan, Anderson, Robin L, Hertzog, Paul J, Andrews, Daniel M, Möller, Andreas, Parker, Belinda S

“…Metastatic progression is the major cause of breast cancer-related mortality. By examining multiple syngeneic preclinical breast cancer models in mice lacking…”
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Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy by WONG, Christina S. F, SCENEAY, Jaclyn, CULLINANE, Carleen, BOWTELL, David D, MÖLLER, Andreas, HOUSE, Colin M, HALSE, Heloise M, LIU, Mira C. P, GEORGE, Joshy, POTDEVIN HUNNAM, Titaina C. U, PARKE, Belinda S, HAVIV, Izhak, RONAI, Ze'ev

“…Tumor hypoxia is associated with resistance to antiangiogenic therapy and poor prognosis. The Siah E3 ubiquitin ligases regulate the hypoxic response pathway…”
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Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer by Askoxylakis, Vasileios, Ferraro, Gino B., Badeaux, Mark, Kodack, David P., Kirst, Isabelle, Shankaraiah, Ram C., Wong, Christina S. F., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.

“…The effective treatment of cerebral metastases from HER2-positive breast cancer remains an unmet need. Recent studies indicate that activated astrocytes and…”
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A C-Terminal Acidic Domain Regulates Degradation of the Transcriptional Coactivator Bob1 by Lindner, John M, Wong, Christina S F, Möller, Andreas, Nielsen, Peter J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression by Chan, Peter, Möller, Andreas, Liu, Mira C P, Sceneay, Jaclyn E, Wong, Christina S F, Waddell, Nic, Huang, Katie T, Dobrovic, Alexander, Millar, Ewan K A, O'Toole, Sandra A, McNeil, Catriona M, Sutherland, Robert L, Bowtell, David D, Fox, Stephen B

“…The seven in absentia homolog 2 (SIAH2) protein plays a significant role in the hypoxic response by regulating the abundance of hypoxia-inducible factor-α;…”
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Evaluation of a Novel Dermal Cooling System for the Treatment of Benign Pigmented Lesions in Asians by Wong, Christina S. M., Chan, Mandy W. M., Shek, Samantha Y. N., Yeung, Chi Keung, Chan, Henry H. L.

“…ABSTRACT Objective Our study aimed to evaluate the efficacy of this novel dermal cooling system (DCS) in reducing pigmentation in benign pigmented lesions in…”
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The use of fractional radiofrequency in Asian patients to improve skin texture by Chan, Mandy W. M., Chan, Agnes W. S., Wong, Christina S. M., Shek, Samantha Y. N., Yeung, Chi Keung, Kono, Taro, Chan, Henry H. L.

“…Background and Objectives Fractional radiofrequency devices have been demonstrated to improve skin texture, such as smoothness, rhytides, brightness, and…”
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The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation by Kodack, David P, Askoxylakis, Vasileios, Ferraro, Gino B, Sheng, Qing, Badeaux, Mark, Goel, Shom, Qi, Xiaolong, Shankaraiah, Ram, Cao, Z Alexander, Ramjiawan, Rakesh R, Bezwada, Divya, Patel, Bhushankumar, Song, Yongchul, Costa, Carlotta, Naxerova, Kamila, Wong, Christina S F, Kloepper, Jonas, Das, Rita, Tam, Angela, Tanboon, Jantima, Duda, Dan G, Miller, C Ryan, Siegel, Marni B, Anders, Carey K, Sanders, Melinda, Estrada, Monica V, Schlegel, Robert, Arteaga, Carlos L, Brachtel, Elena, Huang, Alan, Fukumura, Dai, Engelman, Jeffrey A, Jain, Rakesh K

“…Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that…”
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Emerging strategies for delivering antiangiogenic therapies to primary and metastatic brain tumors by Askoxylakis, Vasileios, Arvanitis, Costas D., Wong, Christina S.F., Ferraro, Gino B., Jain, Rakesh K.

“…Five-year survival rates have not increased appreciably for patients with primary and metastatic brain tumors. Nearly 17,000 patients die from primary brain…”
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Siah2-deficient mice show impaired skin wound repair by Musyoka, James N., Liu, Mira C.P., Pouniotis, Dodie S., Wong, Christina S.F., Bowtell, David D., Little, Peter J., Getachew, Robel, Möller, Andreas, Darby, Ian A.

“…Hypoxia is associated with the dermal wound healing process and hypoxia signaling is presumed to be crucial for normal wound repair. The Siah2 ubiquitin ligase…”
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HLA‐B15:11 status and carbamazepine‐induced severe cutaneous adverse drug reactions in HLA‐B15:02 negative Chinese by Wong, Christina S. M., Yap, Desmond Y. H., Ip, Patrick, Wong, Wilfred H. S., Chua, Gilbert T., Yeung, Chi‐Keung, Chan, Henry H. L., Kwok, Janette S. Y.

“…Background HLA‐B*15:11 is associated with carbamazepine (CBZ)‐induced severe cutaneous adverse drug reactions (SCARs) in Japanese and some Asian populations,…”
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Tardive Dyskinesia in a Postoperative Gynecological Patient After Single Dose Administration of Metoclopramide by Wong, Christina S, Perry, Kyler W, Rosenbaum, Amy

“…Metoclopramide is a dopamine D2-receptor blocking agent commonly used to treat nausea, vomiting, and gastroparesis. Due to their mechanism of action, these…”
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