Search Results - "Wong, Chi Huey"

Oligosaccharide Synthesis and Translational Innovation by Krasnova, Larissa, Wong, Chi-Huey

“…The translation of biological glycosylation in humans to the clinical applications involves systematic studies using homogeneous samples of oligosaccharides…”
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Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives by Dey, Supriya, Wong, Chi-Huey

“…Heparin (H) and heparan sulfate (HS) belong to the glycosaminoglycan (GAG) family of oligosaccharides, and their sequences and sulfation patterns are known to…”
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Toward Automated Oligosaccharide Synthesis by Hsu, Che-Hsiung, Hung, Shang-Cheng, Wu, Chung-Yi, Wong, Chi-Huey

“…Carbohydrates have been shown to play important roles in biological processes. The pace of development in carbohydrate research is, however, relatively slow…”
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Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection by Jan, Jia-Tsrong, Cheng, Ting-Jen Rachel, Juang, Yu-Pu, Ma, Hsiu-Hua, Wu, Ying-Ta, Yang, Wen-Bin, Cheng, Cheng-Wei, Chen, Xiaorui, Chou, Ting-Hung, Shie, Jiun-Jie, Cheng, Wei-Chieh, Chein, Rong-Jie, Mao, Shi-Shan, Liang, Pi-Hui, Ma, Che, Hung, Shang-Cheng, Wong, Chi-Huey

“…The outbreak of COVID-19 caused by SARS-CoV-2 has resulted in more than 50 million confirmed cases and over 1 million deaths worldwide as of November 2020…”
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Automated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions by Chang, Chun‐Wei, Lin, Mei‐Huei, Chan, Chieh‐Kai, Su, Kuan‐Yu, Wu, Chia‐Hui, Lo, Wei‐Chih, Lam, Sarah, Cheng, Yu‐Ting, Liao, Pin‐Hsuan, Wong, Chi‐Huey, Wang, Cheng‐Chung

“…The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable. We have developed a database of acceptor nucleophilic constants…”
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Hierarchical and programmable one-pot synthesis of oligosaccharides by Cheng, Cheng-Wei, Zhou, Yixuan, Pan, Wen-Harn, Dey, Supriya, Wu, Chung-Yi, Hsu, Wen-Lian, Wong, Chi-Huey

“…The programmable one-pot oligosaccharide synthesis method was designed to enable the rapid synthesis of a large number of oligosaccharides, using the software…”
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Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation by Liu, Chiu-Ping, Tsai, Tsung-I., Cheng, Ting, Shivatare, Vidya S., Wu, Chung-Yi, Wong, Chi-Huey

“…Monoclonal antibodies (mAbs) have been developed as therapeutics, especially for the treatment of cancer, inflammation, and infectious diseases. Because the…”
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Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response by Chen, Jung-Tsu, Chen, Chein-Hung, Ku, Ko-Li, Hsiao, Michael, Chiang, Chun-Pin, Hsu, Tsui-Ling, Chen, Min-Huey, Wong, Chi-Huey

“…The incidence and mortality rate of oral cancer continue to rise, partly due to the lack of effective early diagnosis and increasing environmental exposure to…”
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Broad neutralization coverage of HIV by multiple highly potent antibodies by Walker, Laura M., Huber, Michael, Doores, Katie J., Falkowska, Emilia, Pejchal, Robert, Julien, Jean-Philippe, Wang, Sheng-Kai, Ramos, Alejandra, Chan-Hui, Po-Ying, Moyle, Matthew, Mitcham, Jennifer L., Hammond, Phillip W., Olsen, Ole A., Phung, Pham, Fling, Steven, Wong, Chi-Huey, Phogat, Sanjay, Wrin, Terri, Simek, Melissa D., Principal Investigators, Protocol G., Koff, Wayne C., Wilson, Ian A., Burton, Dennis R., Poignard, Pascal

“…Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we…”
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O-GlcNAcylation regulates EZH2 protein stability and function by Chu, Chi-Shuen, Lo, Pei-Wen, Yeh, Yi-Hsien, Hsu, Pang-Hung, Peng, Shih-Huan, Teng, Yu-Ching, Kang, Ming-Lun, Wong, Chi-Huey, Juan, Li-Jung

“…O-linked N -acetylglucosamine (GlcNAc) transferase (OGT) is the only known enzyme that catalyzes the O-GlcNAcylation of proteins at the Ser or Thr side chain…”
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Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity by Yeh, Shih-Chi, Wang, Pao-Yuan, Lou, Yi-Wei, Khoo, Kay-Hooi, Hsiao, Michael, Hsu, Tsui-Ling, Wong, Chi-Huey

“…The cancer stem cells (CSCs) of glioblastoma multiforme (GBM), a grade IV astrocytoma, have been enriched by the expressed marker CD133. However, recent…”
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A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2 by Liu, Yo-Min, Shahed-Al-Mahmud, Md, Chen, Xiaorui, Chen, Ting-Hua, Liao, Kuo-Shiang, Lo, Jennifer M., Wu, Yi-Min, Ho, Meng-Chiao, Wu, Chung-Yi, Wong, Chi-Huey, Jan, Jia-Tsrong, Ma, Che

“…The influenza virus hemagglutinin (HA) and coronavirus spike (S) protein mediate virus entry. HA and S proteins are heavily glycosylated, making them potential…”
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Anomeric Reactivity-Based One-Pot Synthesis of Heparin-Like Oligosaccharides by Polat, Tülay, Wong, Chi-Huey

“…A highly efficient one-pot methodology is described for the synthesis of heparin and heparan sulfate oligosaccharides utilizing thioglycosides with…”
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Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells by Liu, Ying-Chih, Yen, Hsin-Yung, Chen, Chien-Yu, Chen, Chein-Hung, Cheng, Ping-Fu, Juan, Yi-Hsiu, Chen, Chung-Hsuan, Khoo, Kay-Hooi, Yu, Chong-Jen, Yang, Pan-Chyr, Hsu, Tsui-Ling, Wong, Chi-Huey

“…Protein glycosylation is an important posttranslational process, which regulates protein folding and functional expression. Studies have shown that abnormal…”
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Synthesis and Quantitative Analysis of Glycans Conjugated to Gold Nanoparticles by Liao, Kuo‐Shiang, Kung, Chih‐Chuan, Cheng, Li‐Chun, Chung, Cinya, Wong, Chi‐Huey

“…Nanoparticles, especially gold nanoparticles (GNPs) have emerged as promising tools for biomedical applications due to their unique properties and ability to…”
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A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield by Pejchal, Robert, Doores, Katie J., Walker, Laura M., Khayat, Reza, Huang, Po-Ssu, Wang, Sheng-Kai, Stanfield, Robyn L., Julien, Jean-Philippe, Ramos, Alejandra, Crispin, Max, Depetris, Rafael, Katpally, Umesh, Marozsan, Andre, Cupo, Albert, Maloveste, Sebastien, Liu, Yan, McBride, Ryan, Ito, Yukishige, Sanders, Rogier W., Ogohara, Cassandra, Paulson, James C., Feizi, Ten, Scanlan, Christopher N., Wong, Chi-Huey, Moore, John P., Olson, William C., Ward, Andrew B., Poignard, Pascal, Schief, William R., Burton, Dennis R., Wilson, Ian A.

“…The HIV envelope (Env) protein gpl20 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly…”
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Quantitative Analysis of Carbohydrate−Protein Interactions Using Glycan Microarrays:  Determination of Surface and Solution Dissociation Constants by Liang, Pi-Hui, Wang, Sheng-Kai, Wong, Chi-Huey

“…Carbohydrate−protein interactions on surface and in solution were quantitatively measured by a glycan microarray. Assessing carbohydrate affinities is…”
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Selectfluor: Mechanistic Insight and Applications by Nyffeler, Paul T., Durón, Sergio Gonzalez, Burkart, Michael D., Vincent, Stéphane P., Wong, Chi-Huey

“…The replacement of hydrogen atoms with fluorine substituents in organic substrates is of great interest in synthetic chemistry because of the strong…”
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Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer by Chen, Chien-Yu, Jan, Yi-Hua, Juan, Yi-Hsiu, Yang, Chih-Jen, Huang, Ming-Shyan, Yu, Chong-Jen, Yang, Pan-Chyr, Hsiao, Michael, Hsu, Tsui-Ling, Wong, Chi-Huey

“…The up-regulation of fucosyltransferase 8 (FUT8), the only enzyme catalyzing α1,6-fucosylation in mammals, has been observed in several malignant cancers…”
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Design and Synthesis of 6‐O‐Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid β Aggregation by Uchimura, Kenji, Nishitsuji, Kazuchika, Chiu, Li‐Ting, Ohgita, Takashi, Saito, Hiroyuki, Allain, Fabrice, Gannedi, Veeranjaneyulu, Wong, Chi‐Huey, Hung, Shang‐Cheng

“…Dysregulation of amyloidogenic proteins and their abnormal processing and deposition in tissues cause systemic and localized amyloidosis. Formation of amyloid…”
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