Search Results - "Wong, Charng Choon"

Depression, anxiety, and stress among university students in Selangor, Malaysia during COVID-19 pandemics and their associated factors by Wong, Shun Sun, Wong, Charng Choon, Ng, Kwok Wen, Bostanudin, Mohammad F, Tan, Suk Fei

“…This study aims to assess the impacts of COVID-19 pandemics among university students in Malaysia, by identifying the prevalence of depression, anxiety and…”
Get full text

Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound by Abdul Latip, Ahmad Faiz, Hussein, Mohd Zobir, Stanslas, Johnson, Wong, Charng Choon, Adnan, Rohana

“…Background Layered hydroxides salts (LHS), a layered inorganic compound is gaining attention in a wide range of applications, particularly due to its unique…”
Get full text

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog by Wong, Charng Choon, Periasamy, Nagarajan, Sagineedu, Sreenivasa Rao, Sidik, Shiran, Sumon, Shariful Hasan, Loadman, Paul, Phillips, Roger, Lajis, Nordin Haji, Stanslas, Johnson

“…Summary Limited tumor penetrability of anti-cancer drugs is recognized as one of the major factors that lead to poor anti-tumor activity. SRJ09…”
Get full text

Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines by Quah, Shun Ying, Wong, Charng Choon, Wong, Hui Chyn, Ho, Kok Lian, Abdul Manan, Nizar, Deb, Pran Kishore, Sagineedu, Sreenivasa Rao, Stanslas, Johnson

“…Chemoresistance poses a major hurdle to cancer treatments. Andrographolide-derived SRJ09 and SRJ23 were reported to exhibit potent, selective inhibitory…”
Get full text

SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy by Wong, Charng Choon, Lim, Siang Hui, Sagineedu, Sreenivasa Rao, Lajis, Nordin Haji, Stanslas, Johnson

“…[Display omitted] SRJ09 (3,19-(2-bromobenzylidene)andrographolide), a semisynthetic andrographolide (AGP) derivative, was shown to induce G1 cell cycle arrest…”
Get full text

Abstract 4454: SRJ09, a semisynthetic anticancer agent, targets Ras-MAPK signaling pathway: assessment in breast and colon cancer cell lines by Stanslas, Johnson, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Sidik, Shiran Mohd, Sumon, Shariful Hasan, Phillips, Roger, Lajis, Nordin Haji

“…SRJ09 (3,19-(2-bromobenzylidene)andrographolide) was shown to be more selective towards breast and colon cancers in USA NCI 60 cancer cell line screen, thus…”
Get full text

In vitro 3D evaluation of penetrability of SRJ09, a semisynthetic anticancer agent (1048.4) by Wong, Charng Choon, Periasamy, Nagarajan, Sagineedu, Sreenivasa, Sidik, Shiran, Sumon, Shariful, Phillips, Roger, Lajis, Nordin, Stanslas, Johnson

“…The inability of anticancer drugs to penetrate through the tumor within their respective pharmacokinetic lifespan to destroy all the tumor cells is recognized…”
Get full text

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide by Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Sumon, Shariful Hasan, Sidik, Shiran Mohamad, Phillips, Roger, Lajis, Nordin H, Stanslas, Johnson

“…Highlights • Andrographolide (AGP) has been shown to possess promising anticancer activity. • We evaluated the anticancer potential of newer AGP derivatives. •…”
Get full text

SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells by Wong, Hui Chyn, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Loke, Seng Cheong, Lajis, Nordin Haji, Stanslas, Johnson

“…Purpose 3,19-(3-Chloro-4-fluorobenzylidene)andrographolide (SRJ23), a new semisynthetic derivative of andrographolide (AGP), exhibited selectivity against…”
Get full text

Abstract C147: Mechanism of resistance to a semisynthetic anticancer andrographolide derivative: Possible involvement of Ras-MAPK signaling pathway by Stanslas, Johnson, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Sidik, Shiran, Sumon, Shariful Hasan, Phillips, Roger, Lajis, Nordin Haji

“…SRJ09 (3,19-(2-bromobenzylidene)andrographolide) has been identified as a lead anticancer agent on the basis of its selectivity towards breast and colon…”
Get full text

Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets by Stanslas, Johnson, Lim, Siang Hui, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Lajis, Nordin Haji

“…Using andrographolide (AGP) as a template, a series of semisynthetic analogues was synthesised for the discovery of new anticancer agent(s) with improved…”
Get full text