Search Results - "Wong, Cassandra J."

Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling by Wigington, Callie P., Roy, Jagoree, Damle, Nikhil P., Yadav, Vikash K., Blikstad, Cecilia, Resch, Eduard, Wong, Cassandra J., Mackay, Douglas R., Wang, Jennifer T., Krystkowiak, Izabella, Bradburn, Devin A., Tsekitsidou, Eirini, Hong, Su Hyun, Kaderali, Malika Amyn, Xu, Shou-Ling, Stearns, Tim, Gingras, Anne-Claude, Ullman, Katharine S., Ivarsson, Ylva, Davey, Norman E., Cyert, Martha S.

“…Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them…”
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Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions by Xiong, Emily H., Zhang, Xiang, Yan, Huijuan, Ward, Henry N., Lin, Zhen-Yuan, Wong, Cassandra J., Fu, Ci, Gingras, Anne-Claude, Noble, Suzanne M., Robbins, Nicole, Myers, Chad L., Cowen, Leah E.

“…Fungal pathogens such as Candida albicans pose a significant threat to human health with limited treatment options available. One strategy to expand the…”
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The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans by Case, Nicola T., Duah, Kwamaa, Larsen, Brett, Wong, Cassandra J., Gingras, Anne-Claude, O’Meara, Teresa R., Robbins, Nicole, Veri, Amanda O., Whitesell, Luke, Cowen, Leah E.

“…Evasion of killing by immune cells is crucial for fungal survival in the host. For the human fungal pathogen Candida albicans, internalization by macrophages…”
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Functional divergence of a global regulatory complex governing fungal filamentation by Polvi, Elizabeth J, Veri, Amanda O, Liu, Zhongle, Hossain, Saif, Hyde, Sabrina, Kim, Sang Hu, Tebbji, Faiza, Sellam, Adnane, Todd, Robert T, Xie, Jinglin L, Lin, Zhen-Yuan, Wong, Cassandra J, Shapiro, Rebecca S, Whiteway, Malcolm, Robbins, Nicole, Gingras, Anne-Claude, Selmecki, Anna, Cowen, Leah E

“…Morphogenetic transitions are prevalent in the fungal kingdom. For a leading human fungal pathogen, Candida albicans, the capacity to transition between yeast…”
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A proximity-dependent biotinylation map of a human cell by Go, Christopher D., Knight, James D. R., Rajasekharan, Archita, Rathod, Bhavisha, Hesketh, Geoffrey G., Abe, Kento T., Youn, Ji-Young, Samavarchi-Tehrani, Payman, Zhang, Hui, Zhu, Lucie Y., Popiel, Evelyn, Lambert, Jean-Philippe, Coyaud, Étienne, Cheung, Sally W. T., Rajendran, Dushyandi, Wong, Cassandra J., Antonicka, Hana, Pelletier, Laurence, Palazzo, Alexander F., Shoubridge, Eric A., Raught, Brian, Gingras, Anne-Claude

“…Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations…”
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Trace Sample Proteome Quantification by Data-Dependent Acquisition without Dynamic Exclusion by Wu, Ci, Lei, Jiao, Meng, Fei, Wang, Xingyao, Wong, Cassandra J., Peng, Jiaxi, Lin, Ge, Gingras, Anne-Claude, Ma, Junfeng, Zhang, Shen

“…Despite continuous technological improvements in sample preparation, mass-spectrometry-based proteomics for trace samples faces the challenges of sensitivity,…”
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Mapping Protein–Protein Interactions Using Data-Dependent Acquisition without Dynamic Exclusion by Zhang, Shen, Larsen, Brett, Colwill, Karen, Wong, Cassandra J., Youn, Ji-Young, Gingras, Anne-Claude

“…Systematic analysis of affinity-purified samples by liquid chromatography coupled to mass spectrometry (LC-MS) requires high coverage, reproducibility, and…”
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High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles by Coupland, Claire E, Karimi, Ryan, Bueler, Stephanie A, Liang, Yingke, Courbon, Gautier M, Di Trani, Justin M, Wong, Cassandra J, Saghian, Rayan, Youn, Ji-Young, Wang, Lu-Yang, Rubinstein, John L

“…Intercellular communication in the nervous system occurs through the release of neurotransmitters into the synaptic cleft between neurons. In the presynaptic…”
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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration by Khazaei, Sima, Chen, Carol C.L., Andrade, Augusto Faria, Kabir, Nisha, Azarafshar, Pariya, Morcos, Shahir M., França, Josiane Alves, Lopes, Mariana, Lund, Peder J., Danieau, Geoffroy, Worme, Samantha, Adnani, Lata, Nzirorera, Nadine, Chen, Xiao, Yogarajah, Gayathri, Russo, Caterina, Zeinieh, Michele, Wong, Cassandra J., Bryant, Laura, Hébert, Steven, Tong, Bethany, Sihota, Tianna S., Faury, Damien, Puligandla, Evan, Jawhar, Wajih, Sandy, Veronica, Cowan, Mitra, Nakada, Emily M., Jerome-Majewska, Loydie A., Ellezam, Benjamin, Gomes, Carolina Cavalieri, Denecke, Jonas, Lessel, Davor, McDonald, Marie T., Pizoli, Carolyn E., Taylor, Kathryn, Cocanougher, Benjamin T., Bhoj, Elizabeth J., Gingras, Anne-Claude, Garcia, Benjamin A., Lu, Chao, Campos, Eric I., Kleinman, Claudia L., Garzia, Livia, Jabado, Nada

“…Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain…”
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Calcineurin associates with centrosomes and regulates cilia length maintenance by Tsekitsidou, Eirini, Wong, Cassandra J, Ulengin-Talkish, Idil, Barth, Angela I M, Stearns, Tim, Gingras, Anne-Claude, Wang, Jennifer T, Cyert, Martha S

“…Calcineurin, or protein phosphatase 2B (PP2B), the Ca2+ and calmodulin-activated phosphatase and target of immunosuppressants, has many substrates and…”
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Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome by Mabanglo, Mark F., Wong, Keith S., Barghash, Marim M., Leung, Elisa, Chuang, Stephanie H.W., Ardalan, Afshan, Majaesic, Emily M., Wong, Cassandra J., Zhang, Shen, Lang, Henk, Karanewsky, Donald S., Iwanowicz, Andrew A., Graves, Lee M., Iwanowicz, Edwin J., Gingras, Anne-Claude, Houry, Walid A.

“…The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic…”
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Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification by Aprosoff, Camila M., Dyakov, Boris J.A., Cheung, Vivian H.W., Wong, Cassandra J., Palandra, Mikaela, Gingras, Anne-Claude, Wyatt, Haley D.M.

“…The DNA repair scaffold SLX4 has pivotal roles in cellular processes that maintain genome stability, most notably homologous recombination. Germline mutations…”
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Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux by Masud, Sanna N., Chandrashekhar, Megha, Aregger, Michael, Tan, Guihong, Zhang, Xiaoyu, Mero, Patricia, Pirman, David A., Zaslaver, Olga, Smolen, Gromoslaw A., Lin, Zhen-Yuan, Wong, Cassandra J., Boone, Charles, Gingras, Anne-Claude, Montenegro-Burke, J. Rafael, Moffat, Jason

“…Pyrvinium is a quinoline-derived cyanine dye and an approved anti-helminthic drug reported to inhibit WNT signaling and have anti-proliferative effects in…”
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Author Correction: Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux by Masud, Sanna N., Chandrashekhar, Megha, Aregger, Michael, Tan, Guihong, Zhang, Xiaoyu, Mero, Patricia, Pirman, David A., Zaslaver, Olga, Smolen, Gromoslaw A., Lin, Zhen-Yuan, Wong, Cassandra J., Boone, Charles, Gingras, Anne-Claude, Montenegro-Burke, J. Rafael, Moffat, Jason

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Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism by Aregger, Michael, Lawson, Keith A., Billmann, Maximillian, Costanzo, Michael, Tong, Amy H. Y., Chan, Katherine, Rahman, Mahfuzur, Brown, Kevin R., Ross, Catherine, Usaj, Matej, Nedyalkova, Lucy, Sizova, Olga, Habsid, Andrea, Pawling, Judy, Lin, Zhen-Yuan, Abdouni, Hala, Wong, Cassandra J., Weiss, Alexander, Mero, Patricia, Dennis, James W., Gingras, Anne-Claude, Myers, Chad L., Andrews, Brenda J., Boone, Charles, Moffat, Jason

“…The de novo synthesis of fatty acids has emerged as a therapeutic target for various diseases, including cancer. Because cancer cells are intrinsically…”
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Author Correction: A proximity-dependent biotinylation map of a human cell by Go, Christopher D., Knight, James D. R., Rajasekharan, Archita, Rathod, Bhavisha, Hesketh, Geoffrey G., Abe, Kento T., Youn, Ji-Young, Samavarchi-Tehrani, Payman, Zhang, Hui, Zhu, Lucie Y., Popiel, Evelyn, Lambert, Jean-Philippe, Coyaud, Étienne, Cheung, Sally W. T., Rajendran, Dushyandi, Wong, Cassandra J., Antonicka, Hana, Pelletier, Laurence, Palazzo, Alexander F., Shoubridge, Eric A., Raught, Brian, Gingras, Anne-Claude

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Proteomics approaches to decipher new signaling pathways by Gingras, Anne-Claude, Wong, Cassandra JJ

“…•Recent advances in global phosphoproteomics help discover crosstalks and feedback loops.•Monitoring phosphorylation dynamics permits to reveal proximal and…”
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Potent ClpP agonists with anticancer properties bind the protease with improved structural complementarity and alter the mitochondrial N-terminome by Mabanglo, Mark F., Wong, Keith S., Barghash, Marim M., Leung, Elisa, Chuang, Stephanie H. W., Ardalan, Afshan, Majaesic, Emily M., Wong, Cassandra J., Zhang, Shen, Lang, Henk, Karanewsky, Donald S., Iwanowicz, Andrew A., Graves, Lee M., Iwanowicz, Edwin J., Gingras, Anne-Claude, Houry, Walid A.

“…The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic…”
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