Search Results - "Wong, Caíne"
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Sulfated glycans and elevated temperature stimulate PrPSc‐dependent cell‐free formation of protease‐resistant prion protein
Published in The EMBO journal (01-02-2001)“…A conformational conversion of the normal, protease‐ sensitive prion protein (PrP‐sen or PrPC) to a protease‐resistant form (PrP‐res or PrPSc) is commonly…”
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A solid-phase assay for identification of modulators of prion protein interactions
Published in Analytical biochemistry (01-12-2003)“…The progression of the transmissible spongiform encephalopathies (TSEs) is characterized in part by accumulation of a proteinase K-resistant form of the prion…”
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The domain structure of sigma 54 as determined by analysis of a set of deletion mutants
Published in Journal of molecular biology (11-02-1994)“…Escherichia coli sigma 54 was analyzed by making a series of 16 internal deletions within its gene and analyzing the properties of the mutant proteins. All of…”
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Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Published in Biochemical and biophysical research communications (16-05-1984)“…A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated by…”
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Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome
Published in Neuron (Cambridge, Mass.) (28-02-2002)“…Most Down's syndrome (DS) patients develop Alzheimer's disease (AD) neuropathology. Astrocyte and neuronal cultures derived from fetal DS brain show…”
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Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein
Published in The EMBO journal (01-02-2001)“…A conformational conversion of the normal, protease- sensitive prion protein (PrP-sen or PrP(C)) to a protease-resistant form (PrP-res or PrP(Sc)) is commonly…”
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Interactions and conversions of prion protein isoforms
Published in Advances in Protein Chemistry (2001)“…The properties of amyloidogenic protease-resistant form (PrP-res) have failed attempts to determine its high resolution structure. Nonetheless, low resolution…”
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Book Chapter Journal Article -
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Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer's Disease
Published in The Journal of neuroscience (01-07-1997)“…Mutations in the presenilin-1 (PS1) gene is a cause of early- onset familial Alzheimer's disease (AD). Endogenous PS1 is associated with the endoplasmic…”
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Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein
Published in Biochemical and biophysical research communications (16-08-1984)“…The cerebrovascular amyloid protein from a case of adult Down's syndrome was isolated and purified. Amino acid sequence analysis showed it to be homologous to…”
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Altered Metabolism of the Amyloid [beta] Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome
Published in Neuron (Cambridge, Mass.) (28-02-2002)“…Most Down's syndrome (DS) patients develop Alzheimer's disease (AD) neuropathology. Astrocyte and neuronal cultures derived from fetal DS brain show…”
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Sulfated glycans and elevated temperature stimulate PrP Sc -dependent cell-free formation of protease-resistant prion protein
Published in The EMBO journal (01-02-2001)Get full text
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Neuritic Plaques and Cerebrovascular Amyloid in Alzheimer Disease are Antigenically Related
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-1985)“…A synthetic peptide (Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr), homologous to the amino terminus of a protein purified from cerebrovascular amyloid (β protein),…”
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A role for the acidic trimer repeat region of transcription factor sigma super(54) in setting the rate and temperature dependence of promoter melting in vivo
Published in The Journal of biological chemistry (01-01-1992)“…sigma super(54) is an atypical sigma factor involved in enhancer-dependent transcription in Escherichia coli . In vivo assays were developed for following the…”
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RNA Polymerase Binding Using a Strongly Acidic Hydrophobic-Repeat Region of σ54
Published in Proceedings of the National Academy of Sciences - PNAS (15-03-1994)“…σ54is a rare bacterial protein that substitutes for σ70in the case of Escherichia coli genes transcribed by certain activators with enhancer protein-like…”
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Identification of functional domains of Escherichia coli sigma 54 protein by mutational analysis and the role of two acidic amino acid motifs of sigma 54 in transcription initiation
Published 01-01-1993“…Sigma 54 is an alternative sigma protein in E. coli. When complexed to the core RNA polymerase, it participates in enhancer dependent transcription. Functions…”
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Dissertation -
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Immunohistochemical Evidence for the Derivation of a Peptide Ligand from the Amyloid β -Protein Precursor of Alzheimer Disease
Published in Proceedings of the National Academy of Sciences - PNAS (01-04-1988)“…A monoclonal antibody to a synthetic peptide consisting of residues 8-17 of the amyloid β protein of Alzheimer disease was used in immunohistochemical studies…”
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Amyloid beta-protein gene duplication is not common in Alzheimer's disease: analysis by polymorphic restriction fragments
Published in Biochemical and biophysical research communications (15-01-1988)“…The amyloid beta-protein(BP) is an important component of amyloid fibrils of both Alzheimer's disease(AD) and adult Down syndrome(DS). It has been hypothesized…”
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A HindIII polymorphism detected by the cDNA encoding amyloid beta protein of Alzheimer's disease
Published in Nucleic acids research (11-08-1987)Get full text
Journal Article