Search Results - "Wong, C. C."

Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches by Wong, C C, Qian, Y, Yu, J

“…Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via…”
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Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis by Wong, Yvette C., Ysselstein, Daniel, Krainc, Dimitri

“…Formation of inter-organelle contacts between mitochondria and lysosomes, regulated by lysosomal RAB7 GTP hydrolysis, allows for bidirectional regulation of…”
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Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1 by Peng, Wesley, Wong, Yvette C., Krainc, Dimitri

“…Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both organelles has been implicated in numerous diseases. Recently,…”
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Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer by Liu, L, Wong, C C, Gong, B, Yu, J

“…Accumulative studies revealed that E3 ubiquitin ligases have important roles in colorectal carcinogenesis. The pathogenic mechanisms of colorectal cancer (CRC)…”
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Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease by Nguyen, Maria, Wong, Yvette C., Ysselstein, Daniel, Severino, Alex, Krainc, Dimitri

“…The discovery of genetic forms of Parkinson’s disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative stress…”
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Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis by Wong, Yvette C., Kim, Soojin, Peng, Wesley, Krainc, Dimitri

“…Mitochondrial and lysosomal function are intricately related and critical for maintaining cellular homeostasis, as highlighted by multiple diseases linked to…”
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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation by Wong, Yvette C, Holzbaur, Erika L F

“…Significance In mitophagy, damaged mitochondria recruit parkin to ubiquitinate proteins on the outer mitochondrial membrane, targeting mitochondria for…”
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Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease by Kim, Soojin, Wong, Yvette C., Gao, Fanding, Krainc, Dimitri

“…Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human…”
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From reads to insight: a hitchhiker's guide to ATAC-seq data analysis by Yan, Feng, Powell, David R, Curtis, David J, Wong, Nicholas C

“…Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely used in studying chromatin biology, but a comprehensive review of the analysis tools…”
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Nasopharyngeal carcinoma: an evolving paradigm by Wong, Kenneth C. W., Hui, Edwin P., Lo, Kwok-Wai, Lam, Wai Kei Jacky, Johnson, David, Li, Lili, Tao, Qian, Chan, Kwan Chee Allen, To, Ka-Fai, King, Ann D., Ma, Brigette B. Y., Chan, Anthony T. C.

“…The past three decades have borne witness to many advances in the understanding of the molecular biology and treatment of nasopharyngeal carcinoma (NPC), an…”
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Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits by Wong, C C Y, Meaburn, E L, Ronald, A, Price, T S, Jeffries, A R, Schalkwyk, L C, Plomin, R, Mill, J

“…Autism spectrum disorder (ASD) defines a group of common, complex neurodevelopmental disorders. Although the aetiology of ASD has a strong genetic component,…”
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Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice by Chen, H, Cai, W, Chu, E S H, Tang, J, Wong, C-C, Wong, S H, Sun, W, Liang, Q, Fang, J, Sun, Z, Yu, J

“…Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC). However, the direct causative effect of COX-2 in spontaneous HCC formation remains…”
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Short- and potential long-term adverse health outcomes of COVID-19: a rapid review by Leung, T. Y. M., Chan, A. Y. L., Chan, E. W., Chan, V. K. Y., Chui, C. S. L., Cowling, B. J., Gao, L., Ge, M. Q., Hung, I. F. N., Ip, M. S. M., Ip, P., Lau, K. K., Lau, C. S., Lau, L. K. W., Leung, W. K., Li, X., Luo, H., Man, K. K. C., Ng, V. W. S., Siu, C. W., Wan, E. Y. F., Wing, Y. K., Wong, C. S. M., Wong, K. H. T., Wong, I. C. K.

“…The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of patients infected worldwide and indirectly affecting even more individuals through…”
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Optimization of signalized network configurations using the Lane-based method by Wong, C K, Liu, Yi

“…Vehicle movements at signalized intersections should follow the guidance of lane marking arrows. Turns are permitted or banned depending on the existence of…”
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Amyloid precursor protein processing and Alzheimer's disease by O'Brien, Richard J, Wong, Philip C

“…Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide (Aβ) within the brain along…”
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The Efficacy of Violence Prediction: A Meta-Analytic Comparison of Nine Risk Assessment Tools by Yang, Min, Wong, Stephen C. P, Coid, Jeremy

“…Actuarial risk assessment tools are used extensively to predict future violence, but previous studies comparing their predictive accuracies have produced…”
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Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2 by Wong, Yvette C., Peng, Wesley, Krainc, Dimitri

“…Properly regulated mitochondrial networks are essential for cellular function and implicated in multiple diseases. Mitochondria undergo fission and fusion…”
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Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition by Pavankumar, Theetha L, Wong, C Jason, Wong, Yun Ka, Spies, Maria, Kowalczykowski, Stephen C

“…Abstract The loading of RecA onto ssDNA by RecBCD is an essential step of RecBCD-mediated homologous recombination. RecBCD facilitates RecA-loading onto ssDNA…”
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The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation by Wong, Yvette C, Holzbaur, Erika L F

“…Autophagy is an essential cellular pathway for degrading defective organelles and aggregated proteins. Defects in autophagy have been implicated in the…”
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Structure of a yeast spliceosome at 3.6-angstrom resolution by Yan, Chuangye, Hang, Jing, Wan, Ruixue, Huang, Min, Wong, Catherine C. L., Shi, Yigong

“…Splicing of precursor messenger RNA (pre-mRNA) in yeast is executed by the spliceosome, which consists of five small nuclear ribonucleoproteins (snRNPs), NTC…”
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