Search Results - "Wong, Bibiana K.Y"

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice by Wong, Bibiana K.Y, Ehrnhoefer, Dagmar E, Graham, Rona K, Martin, Dale D.O, Ladha, Safia, Uribe, Valeria, Stanek, Lisa M, Franciosi, Sonia, Qiu, Xiaofan, Deng, Yu, Kovalik, Vlad, Zhang, Weining, Pouladi, Mahmoud A, Shihabuddin, Lamya S, Hayden, Michael R

“…Abstract Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin ( HTT ) gene that encodes a…”
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Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development by Hayden, Michael R, Ehrnhoefer, Dagmar E, Wong, Bibiana K. Y

“…Key Points Although their aetiology is different, neurodegenerative diseases such as Alzheimer's disease and Huntington's disease have remarkable similarities…”
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Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice by URIBE, Valeria, WONG, Bibiana K. Y, YU DENG, FRANCIOSI, Sonia, BISSADA, Nagat, SPREEUW, Amanda, WEINING ZHANG, EHRNHOEFER, Dagmar E, VAID, Kuljeet, MILLER, Freda D, DESHMUKH, Mohanish, HOWLAND, David, GRAHAM, Rona K, HARDEN, Michael R, CUSACK, Corey L, SKOTTE, Niels H, POULADI, Mahmoud A, YUANYUN XIE, FEINBERG, Konstantin, YIMIAO OU, YINGBIN OUYANG

“…Apoptosis, or programmed cell death, is a cellular pathway involved in normal cell turnover, developmental tissue remodeling, embryonic development, cellular…”
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Aicardi syndrome, an unsolved mystery: Review of diagnostic features, previous attempts, and future opportunities for genetic examination by Wong, Bibiana K. Y., Sutton, V. Reid

“…Aicardi syndrome is a rare, severe neurodevelopmental disorder classically characterized by the triad of infantile spasms, central chorioretinal lacunae, and…”
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Paralog Studies Augment Gene Discovery: DDX and DHX Genes by Paine, Ingrid, Posey, Jennifer E., Grochowski, Christopher M., Jhangiani, Shalini N., Rosenheck, Sarah, Kleyner, Robert, Marmorale, Taylor, Yoon, Margaret, Wang, Kai, Robison, Reid, Cappuccio, Gerarda, Pinelli, Michele, Magli, Adriano, Coban Akdemir, Zeynep, Hui, Joannie, Yeung, Wai Lan, Wong, Bibiana K.Y., Ortega, Lucia, Bekheirnia, Mir Reza, Bierhals, Tatjana, Hempel, Maja, Johannsen, Jessika, Santer, René, Aktas, Dilek, Alikasifoglu, Mehmet, Bozdogan, Sevcan, Aydin, Hatip, Karaca, Ender, Bayram, Yavuz, Ityel, Hadas, Dorschner, Michael, White, Janson J., Wilichowski, Ekkehard, Wortmann, Saskia B., Casella, Erasmo B., Kitajima, Joao Paulo, Kok, Fernando, Monteiro, Fabiola, Muzny, Donna M., Bamshad, Michael, Gibbs, Richard A., Sutton, V. Reid, Van Esch, Hilde, Brunetti-Pierri, Nicola, Hildebrandt, Friedhelm, Brautbar, Ariel, Van den Veyver, Ignatia B., Glass, Ian, Lessel, Davor, Lyon, Gholson J., Lupski, James R.

“…Members of a paralogous gene family in which variation in one gene is known to cause disease are eight times more likely to also be associated with human…”
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Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development by Ehrnhoefer, Dagmar E., Wong, Bibiana K.Y., Hayden, Michael R.

“…Neurodegenerative diseases exemplified by Alzheimer’s and Huntington disease are characterized by the progressive neuropsychiatric dysfunction and loss of…”
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Co-activator candidate interactions for orphan nuclear receptor NR2E1 by Corso-Díaz, Ximena, de Leeuw, Charles N, Alonso, Vivian, Melchers, Diana, Wong, Bibiana K Y, Houtman, René, Simpson, Elizabeth M

“…NR2E1 (Tlx) is an orphan nuclear receptor that regulates the maintenance and self-renewal of neural stem cells, and promotes tumourigenesis. Nr2e1-null mice…”
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regulatory toolbox of MiniPromoters to drive selective expression in the brain by Portales-Casamar, Elodie, Swanson, Douglas J, Liu, Li, Leeuw, Charles N. de, Banks, Kathleen G, Ho Sui, Shannan J, Fulton, Debra L, Ali, Johar, Amirabbasi, Mahsa, Arenillas, David J, Babyak, Nazar, Black, Sonia F, Bonaguro, Russell J, Brauer, Erich, Candido, Tara R, Castellarin, Mauro, Chen, Jing, Chen, Ying, Cheng, Jason C.Y, Chopra, Vik, Docking, T. Roderick, Dreolini, Lisa, D'Souza, Cletus A, Flynn, Erin K, Glenn, Randy, Hatakka, Kristi, Hearty, Taryn G, Imanian, Behzad, Jiang, Steven, Khorasan-zadeh, Shadi, Komljenovic, Ivana, Laprise, Stéphanie, Liao, Nancy Y, Lim, Jonathan S, Lithwick, Stuart, Liu, Flora, Liu, Jun, Lu, Meifen, McConechy, Melissa, McLeod, Andrea J, Milisavljevic, Marko, Mis, Jacek, O'Connor, Katie, Palma, Betty, Palmquist, Diana L, Schmouth, Jean-François, Swanson, Magdalena I, Tam, Bonny, Ticoll, Amy, Turner, Jenna L, Varhol, Richard, Vermeulen, Jenny, Watkins, Russell F, Wilson, Gary, Wong, Bibiana K.Y, Wong, Siaw H, Wong, Tony Y.T, Yang, George S, Ypsilanti, Athena R, Jones, Steven J.M, Holt, Robert A, Goldowitz, Daniel, Wasserman, Wyeth W, Simpson, Elizabeth M

“…The Pleiades Promoter Project integrates genomewide bioinformatics with large-scale knockin mouse production and histological examination of expression…”
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Independent variant analysis of TEAD1 and OCEL1 in 38 Aicardi syndrome patients by Wong, Bibiana K. Y., Sutton, Vernon R., Lewis, Richard A., Van den Veyver, Ignatia B.

“…Background Aicardi syndrome is a severe neurodevelopmental disorder characterized by infantile spasms, typical chorioretinal lacunae, agenesis of the corpus…”
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Hyperactivity, startle reactivity and cell‐proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1frc/frc mice by Wong, B. K. Y., Hossain, S. M., Trinh, E., Ottmann, G. A., Budaghzadeh, S., Zheng, Q.Y., Simpson, E. M.

“…The NR2E1 region on Chromosome 6q21‐22 has been repeatedly linked to bipolar disorder (BP) and NR2E1 has been associated with BP, and more specifically bipolar…”
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