Search Results - "Wong, Alice S.T."

Selectins: An Important Family of Glycan-Binding Cell Adhesion Molecules in Ovarian Cancer by Hassan, Ayon A., Artemenko, Margarita, Tang, Maggie K.S., Wong, Alice S.T.

“…Ovarian cancer is the most lethal gynecological malignancy worldwide. Unlike most other tumor types that metastasize via the vasculature, ovarian cancer…”
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p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells by Pon, Yuen L, Zhou, Hong Y, Cheung, Annie N Y, Ngan, Hextan Y S, Wong, Alice S T

“…p70 S6 kinase (p70(S6K)) is a downstream effector of phosphatidylinositol 3-kinase and is frequently activated in human ovarian cancer. Here we show that…”
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Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 by CHEUNG, Lydia W. T, LEUNG, Peter C. K, WONG, Alice S. T

“…Gonadotropin-releasing hormone (GnRH) receptor is present in 80% of ovarian cancer, and numerous studies have provided evidence for a role of GnRH in cell…”
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Picoinjection-Enabled Multitarget Loop-Mediated Isothermal Amplification for Detection of Foodborne Pathogens by Yuan, Hao, Chao, Youchuang, Li, ShanShan, Tang, Matthew Y. H, Huang, Yue, Che, You, Wong, Alice S. T, Zhang, Tong, Shum, Ho Cheung

“…In this study, we develop a method to detect multiple DNAs of foodborne pathogens by encapsulating emulsion droplets for loop-mediated isothermal amplification…”
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Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer by Han, Qing, Xie, Qian Rueben, Li, Fan, Cheng, Yirui, Wu, Tingyu, Zhang, Yanshuang, Lu, Xin, Wong, Alice S T, Sha, Jianjun, Xia, Weiliang

“…The treatment for metastatic castration-resistant prostate cancer patients remains a great challenge in the clinic and continuously demands discoveries of new…”
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Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues by Cheung, Lydia W.T, Wong, Alice S.T

“…Gonadotropin-releasing hormone (GnRH) has historically been known as a pituitary hormone; however, in the past few years, interest has been raised in locally…”
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Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition by Shi, Zeyu, To, Sally K Y, Zhang, Shuaishuai, Deng, Shan, Artemenko, Margarita, Zhang, Minda, Tang, Juan, Zeng, Jin-Zhang, Wong, Alice S T

“…Colorectal cancer (CRC) and the associated metastatic lesions are reported to be hypoxic. Hypoxia is a common feature in the tumor microenvironment and a…”
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Exosomes: Emerging biomarkers and targets for ovarian cancer by Tang, Maggie K.S, Wong, Alice S.T

“…Highlights • The tumor microenvironment is the key determining factor to cancer development. • Exosomes are present in ovarian cancer and closely related with…”
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Ginsenoside-Rg1 Induces Vascular Endothelial Growth Factor Expression through the Glucocorticoid Receptor-related Phosphatidylinositol 3-Kinase/Akt and β-Catenin/T-cell Factor-dependent Pathway in Human Endothelial Cells by Leung, Kar Wah, Pon, Yuen Lam, Wong, Ricky N.S., Wong, Alice S.T.

“…Ginsenoside-Rg1, the most prevalent active constituent of ginseng, is a potent proangiogenic factor of vascular endothelial cells. This suggests that Rg1 may…”
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c-Met Overexpression Contributes to the Acquired Apoptotic Resistance of Nonadherent Ovarian Cancer Cells through a Cross Talk Mediated by Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase 1/2 by Tang, Maggie K.S., Zhou, Hong Y., Yam, Judy W.P., Wong, Alice S.T.

“…Ovarian cancer is the most lethal gynecologic cancer mainly because of widespread peritoneal dissemination and malignant ascites. Key to this is the capacity…”
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Adhesion-Independent Mechanism for Suppression of Tumor Cell Invasion by E-Cadherin by Alice S. T. Wong, Gumbiner, Barry M.

“…Loss of E-cadherin expression or function in tumors leads to a more invasive phenotype. In this study, we investigated whether the invasion suppressor activity…”
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Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: Influence of family history of ovarian cancer by S.T. Wong, Alice, Maines‐Bandiera, Sarah L., Rosen, Barry, Wheelock, Margaret J., Johnson, Keith R., Leung, Peter C.K., Roskelley, Calvin D., Auersperg, Nelly

“…Epithelial ovarian carcinomas arise in a simple mesothelium (ovarian surface epithelium, OSE) but exhibit properties of oviductal and endometrial epithelia…”
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Loss of Sprouty2 in human high-grade serous ovarian carcinomas promotes EGF-induced E-cadherin down-regulation and cell invasion by So, Wai-Kin, Cheng, Jung-Chien, Fan, Qianlan, Wong, Alice S.T., Huntsman, David G., Gilks, C. Blake, Leung, Peter C.K.

“…•SPRY2 is down-regulated in high-grade serous ovarian carcinomas.•SPRY2 gene is deleted in high-grade serous ovarian carcinomas.•Overexpression of SPRY2…”
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Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice by Li, Shan-Shan, Ip, Carman K M, Tang, Matthew Y H, Sy, Samuel K H, Yung, Susan, Chan, Tak-Mao, Yang, Mengsu, Shum, Ho Cheung, Wong, Alice S T

“…Ovarian cancer is characterized by extensive peritoneal metastasis, with tumor spheres commonly found in the malignant ascites. This is associated with poor…”
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BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis by Tang, Maggie K.S, Kwong, Ava, Tam, Kar-Fai, Cheung, Annie N.Y, Ngan, Hextan Y.S, Xia, Weiliang, Wong, Alice S.T

“…Abstract Stress adaptation has profound impacts on malignant progression and response to treatment. BRCA1 is an important modulator of cellular stress, but our…”
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Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells by Law, Alice Y.S., Lai, Keng P., Ip, Carman K.M., Wong, Alice S.T., Wagner, Graham F., Wong, Chris K.C.

“…Mammalian stanniocalcin-2 (STC2) is a secreted glycoprotein hormone with a putative role in unfolded protein response and apoptosis. Here we reported that STC2…”
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New insights into the role of soluble E-cadherin in tumor angiogenesis by Tang, Maggie K S, Ip, Philip P, Wong, Alice S T

“…A key to successful metastasis is the formation of new vasculature, known as angiogenesis. Therefore, it is of great interest to unravel the underlying…”
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Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK by Zhou, Hong Yan, Wan, Kai Fung, Ip, Carman K.M., Wong, Chris K.C., Mak, Nai Ki, Lo, Kwok Wai, Wong, Alice S.T.

“…The hepatocyte growth factor (HGF) receptor, Met, is frequently overexpressed in nasopharyngeal cancer (NPC). Here, we showed for the first time that human NPC…”
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Role of endocrine and growth factors on the ovarian surface epithelium by Wong, Alice S. T., Leung, Peter C. K.

“…Epithelial ovarian cancer is a highly fatal disease for which prevention strategies have been limited; in part because of our poor understanding of the…”
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Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation by Wong, Alice S.T, Roskelley, Calvin D, Pelech, Steven, Miller, Dianne, Leung, Peter C.K, Auersperg, Nelly

“…We used an experimental in vitro model of human ovarian surface epithelium (OSE), the tissue of origin of >90% of ovarian cancers, to more precisely define the…”
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