Search Results - "Wong, Alice S. T."

Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview by Wong, Alice S T, Che, Chi-Ming, Leung, Kar-Wah

“…Cancer is one of the leading causes of death worldwide. Ginseng, a key ingredient in traditional Chinese medicine, shows great promise as a new treatment…”
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Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow by Li, Shan-Shan, Ip, Carman K. M., Tang, Matthew Y. H., Tang, Maggie K. S., Tong, Yin, Zhang, Jiangwen, Hassan, Ayon Ahmed, Mak, Abby S. C., Yung, Susan, Chan, Tak-Mao, Ip, Philip P., Lee, Cheuk Lun, Chiu, Philip C. N., Lee, Leo Tsz On, Lai, Hung-Cheng, Zeng, Jin-Zhang, Shum, Ho Cheung, Wong, Alice S. T.

“…Organ-specific colonization suggests that specific cell–cell recognition is essential. Yet, very little is known about this particular interaction. Moreover,…”
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Ascitic fluid shear stress in concert with hepatocyte growth factor drive stemness and chemoresistance of ovarian cancer cells via the c-Met-PI3K/Akt-miR-199a-3p signaling pathway by Hassan, Ayon A., Artemenko, Margarita, Tang, Maggie K. S., Shi, Zeyu, Chen, Lin-Yu, Lai, Hung-Cheng, Yang, Zhenyu, Shum, Ho-Cheung, Wong, Alice S. T.

“…Overcoming drug resistance is an inevitable challenge to the success of cancer treatment. Recently, in ovarian cancer, a highly chemoresistant tumor, we…”
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Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma by Li, Xudan, Chen, Quancheng, Liu, Jie, Lai, Shenjin, Zhang, Minda, Zhen, Tidong, Hu, Hongyu, Gao, Xiang, Wong, Alice S T, Zeng, Jin-Zhang

“…Hepatocellular carcinoma (HCC) commonly possesses chronical elevation of IRE1α-ASK1 signaling. Orphan nuclear receptor Nur77, a promising therapeutic target in…”
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Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface by Tang, Maggie K. S., Yue, Patrick Y. K., Ip, Philip P., Huang, Rui-Lan, Lai, Hung-Cheng, Cheung, Annie N. Y., Tse, Ka Yu, Ngan, Hextan Y. S., Wong, Alice S. T.

“…The limitations of current anti-angiogenic therapies necessitate other targets with complimentary mechanisms. Here, we show for the first time that soluble…”
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Chemoresistance in ovarian cancer: exploiting cancer stem cell metabolism by Li, Shan Shan, Ma, Jing, Wong, Alice S T

“…Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the mainstay treatment for ovarian cancer. Despite the initial response is…”
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Synergistic Effects of Epidermal Growth Factor and Hepatocyte Growth Factor on Human Ovarian Cancer Cell Invasion and Migration: Role of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase by Zhou, Hong Y, Pon, Yuen L, Wong, Alice S. T

“…Ovarian cancer is the primary cause of death from gynecological malignancies with a poor prognosis characterized by widespread peritoneal dissemination…”
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Picoinjection-Enabled Multitarget Loop-Mediated Isothermal Amplification for Detection of Foodborne Pathogens by Yuan, Hao, Chao, Youchuang, Li, ShanShan, Tang, Matthew Y. H, Huang, Yue, Che, You, Wong, Alice S. T, Zhang, Tong, Shum, Ho Cheung

“…In this study, we develop a method to detect multiple DNAs of foodborne pathogens by encapsulating emulsion droplets for loop-mediated isothermal amplification…”
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Pigment Epithelium-Derived Factor Is Estrogen Sensitive and Inhibits the Growth of Human Ovarian Cancer and Ovarian Surface Epithelial Cells by Cheung, Lydia W. T, Au, Simon C. L, Cheung, Annie N. Y, Ngan, Hextan Y. S, Tombran-Tink, Joyce, Auersperg, Nelly, Wong, Alice S. T

“…Epithelial ovarian carcinoma is the most lethal gynecological cancer. However, little is known about the molecular mechanisms underlying the disease…”
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Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress by Ip, Carman K. M., Li, Shan-Shan, Tang, Matthew Y. H., Sy, Samuel K. H., Ren, Yong, Shum, Ho Cheung, Wong, Alice S. T.

“…One of greatest challenges to the successful treatment of cancer is drug resistance. An exciting approach is the eradication of cancer stem cells (CSCs)…”
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p70 S6 kinase as a therapeutic target in cancers: More than just an mTOR effector by Artemenko, Margarita, Zhong, Sophia S.W., To, Sally K.Y., Wong, Alice S.T.

“…p70 S6 kinase (p70S6K) is best known for its regulatory roles in protein synthesis and cell growth by phosphorylating its primary substrate, ribosomal protein…”
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Estrogen Regulates Snail and Slug in the Down-Regulation of E-Cadherin and Induces Metastatic Potential of Ovarian Cancer Cells through Estrogen Receptor α by Park, Se-Hyung, Cheung, Lydia W. T, Wong, Alice S. T, Leung, Peter C. K

“…Tumorigenesis is a multistep process involving dysregulated cell growth and metastasis. Considerable evidence implicates a mitogenic action of estrogen in…”
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Gonadotropins and Ovarian Cancer by Choi, Jung-Hye, Wong, Alice S. T, Huang, He-Feng, Leung, Peter C. K

“…Ovarian epithelial cancer (OEC) accounts for 90% of all ovarian cancers and is the leading cause of death from gynecological cancers in North America and…”
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A Selective β−Catenin‐Metadherin/CEACAM1‐CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor–Macrophage Interaction by To, Sally K. Y., Tang, Maggie K. S., Tong, Yin, Zhang, Jiangwen, Chan, Karen K. L., Ip, Philip P. C., Shi, Jue, Wong, Alice S. T.

“…Tumor heterogeneity plays a key role in cancer relapse and metastasis, however, the distinct cellular behaviors and kinetics of interactions among different…”
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Exosomes: Emerging biomarkers and targets for ovarian cancer by Tang, Maggie K.S, Wong, Alice S.T

“…Highlights • The tumor microenvironment is the key determining factor to cancer development. • Exosomes are present in ovarian cancer and closely related with…”
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Selectins: An Important Family of Glycan-Binding Cell Adhesion Molecules in Ovarian Cancer by Hassan, Ayon A., Artemenko, Margarita, Tang, Maggie K.S., Wong, Alice S.T.

“…Ovarian cancer is the most lethal gynecological malignancy worldwide. Unlike most other tumor types that metastasize via the vasculature, ovarian cancer…”
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Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1 by CHEUNG, Lydia W. T, LEUNG, Kar Wah, WONG, Chris K. C, WONG, Ricky N. S, WONG, Alice S. T

“…Ginsenoside-Rg1, the most prevalent active constituent of Panax ginseng, has been shown to possess potent pro-angiogenic properties and therefore poses special…”
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Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 by CHEUNG, Lydia W. T, LEUNG, Peter C. K, WONG, Alice S. T

“…Gonadotropin-releasing hormone (GnRH) receptor is present in 80% of ovarian cancer, and numerous studies have provided evidence for a role of GnRH in cell…”
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Nur77: a potential therapeutic target in cancer by To, Sally K Y, Zeng, Jin-Zhang, Wong, Alice S T

“…The orphan nuclear receptor Nur77 (also known as NR4A1, NGFIB, TR3, TIS1, NAK-1, or N10) is a unique transcription factor encoded by an immediate early gene…”
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Targeting Estrogen-Related Receptor Alpha Inhibits Epithelial-to-Mesenchymal Transition and Stem Cell Properties of Ovarian Cancer Cells by Lam, Sophia SN, Mak, Abby SC, Yam, Judy WP, Cheung, Annie NY, Ngan, Hextan YS, Wong, Alice ST

“…Epithelial–mesenchymal transition represents a key event in cancer progression and has emerged as a promising anticancer target. Estrogen-related receptor…”
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