Search Results - "Wong, Aimée A."

Intranasal insulin treatment ameliorates spatial memory, muscular strength, and frailty deficits in 5xFAD mice by Gendron, William H., Fertan, Emre, Roddick, Kyle M., Wong, Aimée A., Maliougina, Maria, Hiani, Yassine El, Anini, Younes, Brown, Richard E.

“…•Intranasal insulin (INI) treatment increased forelimb grip strength, and swim speed in 10 month old female 5xFAD mice.•INI reduced frailty scores in 5xFAD…”
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The Influence of Visual Ability on Learning and Memory Performance in 13 Strains of Mice by Brown, Richard E, Wong, Aimee A

“…We calculated visual ability in 13 strains of mice (129SI/Sv1mJ, A/J, AKR/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CAST/EiJ, DBA/2J, FVB/NJ, MOLF/EiJ, SJL/J, SM/J, and…”
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Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb–Williams maze by Fertan, Emre, Wong, Aimée A., Vienneau, Nicole A., Brown, Richard E.

“…The 3xTg-AD mouse model of Alzheimer's disease (AD) has both amyloid beta plaque and tau tangle pathology. However, the results of behavioural testing with…”
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Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1–42 in Alzheimer’s disease by Fertan, Emre, Gendron, William H., Wong, Aimée A., Hanson, Gabrielle M., Brown, Richard E., Weaver, Ian C. G.

“…Reduced insulin-like growth factor 2 (IGF2) levels in Alzheimer’s disease (AD) may be the mechanism relating age-related metabolic disorders to dementia. Since…”
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Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes by Gür, Ezgi, Fertan, Emre, Alkins, Kindree, Wong, Aimée A., Brown, Richard E., Balcı, Fuat

“…Temporal information processing in the seconds‐to‐minutes range is disrupted in patients with Alzheimer's disease (AD). In this study, we investigated the…”
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Early postnatal development of the MDGA2+/- mouse model of synaptic dysfunction by Fertan, Emre, Wong, Aimée A., Montbrun, Thalia S. Garvock-de, Purdon, Michaela K., Roddick, Kyle M., Yamamoto, Tohru, Brown, Richard E.

“…Synaptic dysfunction underlies many neurodevelopmental disorders (NDDs). The membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor…”
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Age-related changes in visual acuity, learning and memory in C57BL/6J and DBA/2J mice by Wong, Aimée A, Brown, Richard E

“…Abstract The DBA/2J mouse is a model of age-related pigmentary glaucoma in humans. Visual detection, pattern discrimination and visual acuity were evaluated in…”
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Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice by Fertan, Emre, Stover, Kurt R.J., Brant, Michael G., Stafford, Paul M., Kelly, Brendan, Diez-Cecilia, Elena, Wong, Aimée A., Weaver, Donald F., Brown, Richard E.

“…The kynurenine pathway metabolizes tryptophan into nicotinamide adenine dinucleotide, producing a number of intermediary metabolites, including 3-hydroxy…”
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The effect of background strain on the behavioral phenotypes of the MDGA2+/− mouse model of autism spectrum disorder by Fertan, Emre, Wong, Aimée A., Purdon, Michaela K., Weaver, Ian C. G., Brown, Richard E.

“…The membrane‐associated mucin (MAM) domain containing glycosylphosphatidylinositol anchor 2 protein single knock‐out mice (MDGA2+/−) are models of ASD. We…”
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Prevention of vision loss protects against age-related impairment in learning and memory performance in DBA/2J mice by Wong, Aimée A, Brown, Richard E

“…The DBA/2J mouse is a model of pigmentary glaucoma in humans as it shows age-related increases in intraocular pressure (IOP), retinal ganglion cell death and…”
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A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucoma by Wong, Aimée A, Brown, Richard E

“…Timoptic-XE treatment was used to examine the relationship between age-related changes in intraocular pressure (IOP), retinal cell loss, visual ability, and…”
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Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer's Disease by Kane, Alice E, Shin, Sooyoun, Wong, Aimee A, Fertan, Emre, Faustova, Natalia S, Howlett, Susan E, Brown, Richard E

“…Mouse models of Alzheimer's disease (AD) exhibit marked differences in life expectancy depending on their genotype and sex. The assessment of frailty could…”
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Adaptive Processes in Thalamus and Cortex Revealed by Silencing of Primary Visual Cortex during Contrast Adaptation by King, Jillian L., Lowe, Matthew P., Stover, Kurt R., Wong, Aimee A., Crowder, Nathan A.

“…Visual adaptation illusions indicate that our perception is influenced not only by the current stimulus but also by what we have seen in the recent past…”
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A mitochondrial therapeutic reverses visual decline in mouse models of diabetes by Alam, Nazia M, Mills, 4th, William C, Wong, Aimee A, Douglas, Robert M, Szeto, Hazel H, Prusky, Glen T

“…Diabetic retinopathy is characterized by progressive vision loss and the advancement of retinal micoraneurysms, edema and angiogenesis. Unfortunately, managing…”
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Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer’s disease by Kosel, Filip, Torres Munoz, Paula, Yang, J. Renee, Wong, Aimee A., Franklin, Tamara B.

“…•5xFAD transgenic mice show a progressive loss of interest in social odours.•5xFAD transgenic mice show no obvious olfactory deficits up to 12 months of…”
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Sex differences in the timing behavior performance of 3xTg-AD and wild-type mice in the peak interval procedure by Gür, Ezgi, Fertan, Emre, Kosel, Filip, Wong, Aimee A., Balcı, Fuat, Brown, Richard E.

“…•3xTg-AD mice have comparable interval timing performance to wild-type mice.•Sex differences were observed in measures of motivation.•Female mice started their…”
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Whisker exploration behaviours in the 5xFAD mouse are affected by sex and retinal degeneration by Grant, Robyn A., Wong, Aimee A., Fertan, Emre, Brown, Richard E.

“…Active whisking in mice and rats is one of the fastest behaviours known in mammals and is used to guide complex behaviours such as exploration and navigation…”
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Cognitive Decline, Cerebral-Spleen Tryptophan Metabolism, Oxidative Stress, Cytokine Production, and Regulation of the Txnip Gene in a Triple Transgenic Mouse Model of Alzheimer Disease by Fertan, Emre, Rodrigues, Gloria J., Wheeler, Ryan V., Goguen, Donna, Wong, Aimee A., James, Hana, Stadnyk, Andrew, Brown, Richard E., Weaver, Ian C.G.

“…Pathologic inflammation in response to injury, infection, or oxidative stress is a proposed mechanism relating cognitive decline to dementia. The kynurenine…”
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Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits by Simanaviciute, Ugne, Ahmed, Jewel, Brown, Richard E, Connor-Robson, Natalie, Farr, Tracy D., Fertan, Emre, Gambles, Nikki, Garland, Huw, Morton, A. Jennifer, Staiger, Jochen F., Skillings, Elizabeth A., Trueman, Rebecca C., Wade-Martins, Richard, Wood, Nigel I., Wong, Aimee A., Grant, Robyn A.

“…•Mice move their whiskers during tactile exploration.•We measure whisker movements and locomotion in 9 mouse strains.•Genotype, background strain, sex and…”
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