Search Results - "Wong, AJ"

Proteolytic Release of CD44 Intracellular Domain and Its Role in the CD44 Signaling Pathway by Okamoto, Isamu, Kawano, Yoshiaki, Murakami, Daizo, Sasayama, Takashi, Araki, Norie, Miki, Toru, Wong, Albert J., Saya, Hideyuki

“…CD44 is a widely distributed cell surface adhesion molecule and is implicated in diverse biological processes. However, the nature of intracellular signaling…”
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Towards a model-based patient selection strategy for proton therapy: External validation of photon-derived Normal Tissue Complication Probability models in a head and neck proton therapy cohort by Blanchard, P, Wong, AJ, Gunn, GB, Garden, AS, Mohamed, ASR, Rosenthal, DI, Crutison, J, Wu, R, Zhang, X, Zhu, XR, Mohan, R, Amin, MV, Fuller, CD, Frank, SJ

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Clinical Validation of a Novel Diagnostic HIV-2 Total Nucleic Acid Qualitative Assay Using the Abbott m2000 Platform: Implications for Complementary HIV-2 Nucleic Acid Testing for the CDC 4th Generation HIV Diagnostic Testing Algorithm by Chang, M, Wong, A.J, Raugi, D.N, Smith, R.A, Seilie, A.M, Ortega, J, Bogusz, K, Sall, F, Ba, S, Seydi, M, Gottlieb, G.S, Coombs, R.W

“…Highlights • A qualitative assay detecting HIV-2 total nucleic acid in patients’ PBMCs. • A second-line assay to resolve HIV-2 sero-indeterminate cases. • Able…”
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The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase by Maroun, Christiane R., Naujokas, Monica A., Holgado-Madruga, Marina, Wong, Albert J., Park, Morag

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The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis by Nitta, R T, Del Vecchio, C A, Chu, A H, Mitra, S S, Godwin, A K, Wong, A J

“…The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase family and have been implicated in tumorigenesis. One isoform in…”
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A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors by Piccione, E C, Lieu, T J, Gentile, C F, Williams, T R, Connolly, A J, Godwin, A K, Koong, A C, Wong, A J

“…The epidermal growth factor receptor (EGFR) is essential to multiple physiological and neoplastic processes via signaling by its tyrosine kinase domain and…”
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Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor by Moscatello, D K, Santra, M, Mann, D M, McQuillan, D J, Wong, A J, Iozzo, R V

“…Decorin, a small leucine-rich proteoglycan, is capable of suppressing the growth of various tumor cell lines when expressed ectopically. In this report, we…”
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Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor by Moscatello, David K., Holgado-Madruga, Marina, Emlet, David R., Montgomery, R. Bruce, Wong, Albert J.

“…The most frequently found alteration of the epidermal growth factor receptor (EGFR) in human tumors is a deletion of exons 2–7. This receptor, termed EGFRvIII,…”
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A Grb2-associated docking protein in EGF- and insulin-receptor signalling by Holgado-Madruga, Marina, Emlet, David R, Moscatello, David K, Godwin, Andrew K, Wong, Albert J

“…The protein Grb2 plays a central role in signalling by receptor protein-tyrosine kinases, where its SH2 domain binds to the receptor and its two SH3 domains…”
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Proteolytic Cleavage of the CD44 Adhesion Molecule in Multiple Human Tumors by Okamoto, Isamu, Tsuiki, Hiromasa, Kenyon, Lawrence C., Godwin, Andrew K., Emlet, David R., Holgado-Madruga, Marina, Lanham, Irene S., Joynes, Christopher J., Vo, Kim T., Guha, Abhijit, Matsumoto, Mitsuhiro, Ushio, Yukitaka, Saya, Hideyuki, Wong, Albert J.

“…Cell surface adhesion molecules are crucial for the development and/or pathogenesis of various diseases including cancer. CD44 has received much interest as a…”
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Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors by MOSCATELLO, D. K, HOLGADO-MADRUGA, M, GODWIN, A. K, RAMIREZ, G, GUNN, G, ZOLTICK, P. W, BIEGEL, J. A, HAYES, R. L, WONG, A. J

“…The epidermal growth factor receptor has received much interest as a target for various antineoplastic agents, but a complication is that many normal tissues…”
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Gab1 Is an Integrator of Cell Death versus Cell Survival Signals in Oxidative Stress by Holgado-Madruga, Marina, Wong, Albert J.

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Expression of constitutively activated EGFrvIII in non-small cell lung cancer by OKAMOTO, Isamu, KENYON, Lawrence C, SUGA, Moritaka, MATSUMOTO, Mitsuhiro, WONG, Albert J, EMLET, David R, MORI, Takeshi, SASAKI, Ji-Ichiro, HIROSAKO, Susumu, ICHIKAWA, Yasuko, KISHI, Hiroto, GODWIN, Andrew K, YOSHIOKA, Masakazu

“…The epidermal growth factor receptor (EGFR) variant type III (variously called EGFRvIII, de2-7 EGFR or deltaEGFR) has an in-frame deletion of the extracellular…”
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Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors by TSUIKI, Hiromasa, TNANI, Mehdi, OKAMOTO, Isamu, KENYON, Lawrence C, EMLET, David R, HOLGADO-MADRUGA, Marina, LANHAM, Irene S, JOYNES, Christopher J, VO, Kim T, WONG, Albert J

“…The c-Jun NH(2)-terminal kinases (JNKs) have a role both in promoting apoptosis and tumorigenesis. The JNKs are encoded by three separate genes (JNK1, 2, and…”
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Grb2-Associated Binder-1 Mediates Phosphatidylinositol 3-Kinase Activation and the Promotion of Cell Survival by Nerve Growth Factor by Holgado-Madruga, Marina, Moscatello, David K., Emlet, David R., Dieterich, Rebekka, Wong, Albert J.

“…Nerve growth factor (NGF) prevents apoptosis through stimulation of the TrkA receptor protein tyrosine kinase. The downstream activation of…”
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The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase by Maroun, Christiane R., Holgado-Madruga, Marina, Royal, Isabelle, Naujokas, Monica A., Fournier, Tanya M., Wong, Albert J., Park, Morag

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Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation by HOLGADO-MADRUGA, Marina, WONG, Albert J

“…Grb2-associated binder 1 (Gab1) is a docking protein that is tyrosine phosphorylated following the activation of multiple cytokine receptors and receptor…”
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Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer by Tang, C K, Gong, X Q, Moscatello, D K, Wong, A J, Lippman, M E

“…Epidermal growth factor receptor vIII (EGFRvIII) is a tumor-specific, ligand-independent, constitutively active variant of the EGFR. Its expression has been…”
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Elevated JNK activation contributes to the pathogenesis of human brain tumors by ANTONYAK, Marc A, KENYON, Lawrence C, GODWIN, Andrew K, JAMES, David C, EMLET, David R, OKAMOTO, Isamu, TNANI, Mehdi, HOLGADO-MADRUGA, Marina, MOSCATELLO, David K, WONG, Albert J

“…The ERK pathway is typically associated with activation of the EGF receptor and has been shown to play a major role in promoting several tumor phenotypes. An…”
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Constitutive Activation of c-Jun N-terminal Kinase by a Mutant Epidermal Growth Factor Receptor by Antonyak, M A, Moscatello, D K, Wong, A J

“…Epidermal growth factor receptor (EGF) variant type III (EGFRvIII) is a constitutively active, naturally occurring mutation of the EGF receptor that is found…”
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