Search Results - "Wonacott, A. J."

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography by Lewis, R. J., Singh, O. M., Smith, C. V., Skarzynski, T., Maxwell, A., Wonacott, A. J., Wigley, D. B.

“…This study describes the first crystal structures of a complex between a DNA topoisomerase and a drug. We present the structures of a 24 kDa N‐terminal…”
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Dihydropyrancarboxamides Related to Zanamivir:  A New Series of Inhibitors of Influenza Virus Sialidases. 2. Crystallographic and Molecular Modeling Study of Complexes of 4-Amino-4H-pyran-6-carboxamides and Sialidase from Influenza Virus Types A and B by Taylor, Neil R, Cleasby, Anne, Singh, Onkar, Skarzynski, Tadeusz, Wonacott, Alan J, Smith, Paul W, Sollis, Steven L, Howes, Peter D, Cherry, Peter C, Bethell, Richard, Colman, Peter, Varghese, Jose

“…The first paper in this series (see previous article) described structure−activity studies of carboxamide analogues of zanamivir binding to influenza virus…”
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Structure of holo-glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus at 1.8 A resolution by Skarzyński, T, Moody, P C, Wonacott, A J

“…The structure of holo-glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus has been crystallographically refined at 1.8 A resolution using…”
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Characterization of the two anion-recognition sites of glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus by site-directed mutagenesis and chemical modification by Corbier, C, Michels, S, Wonacott, A. J, Branlant, G

“…The active site of the glycolytic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) contains two anion recognition sites which have been attributed to the…”
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Coenzyme-induced conformational changes in glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus by Skarzyński, T, Wonacott, A J

“…The structure of apo-glyceraldehyde-3-phosphate dehydrogenase (GAPDHase) from Bacillus stearothermophilus has been refined using a restrained least-squares…”
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Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein by Lewis, R J, Singh, O M, Smith, C V, Maxwell, A, Skarzynski, T, Wonacott, A J, Wigley, D B

“…A 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein has been crystallized in the presence of novobiocin. One crystal form has been…”
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X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity by Dajani, R, Cleasby, A, Neu, M, Wonacott, A J, Jhoti, H, Hood, A M, Modi, S, Hersey, A, Taskinen, J, Cooke, R M, Manchee, G R, Coughtrie, M W

“…Humans are one of the few species that produce large amounts of catecholamine sulfates, and they have evolved a specific sulfotransferase, SULT1A3 (M-PST), to…”
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4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase by Howes, Peter D, Cleasby, Anne, Evans, Derek N, Feilden, Helen, Smith, Paul W, Sollis, Steven L, Taylor, Neil, Wonacott, Alan J

“…Two methods for the synthesis of 4-acetylamino benzoic acids substituted at the 3-position with imidazoles are described. Many of the compounds are inhibitors…”
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The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin by Tsai, Francis T.F., Singh, Onkar M.P., Skarzynski, Tadeusz, Wonacott, Alan J., Weston, Simon, Tucker, Alec, Pauptit, Richard A., Breeze, Alexander L., Poyser, J. Philip, O'Brien, Ronan, Ladbury, John E., Wigley, Dale B.

“…Coumarin antibiotics, such as clorobiocin, novobiocin, and coumermycin A1, inhibit the supercoiling activity of gyrase by binding to the gyrase B (GyrB)…”
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Crystallization of the globular domain of histone H5 by Graziano, V, Gerchman, S E, Wonacott, A J, Sweet, R M, Wells, J R, White, S W, Ramakrishnan, V

“…The globular domain of histone H1/H5 binds to the nucleosome and is crucial for the formation of chromatin higher order structure. We have expressed in…”
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Crystallization and preliminary X-ray analysis of porcine synovial collagenase by Lloyd, L F, Skarzyński, T, Wonacott, A J, Cawston, T E, Clark, I M, Mannix, C J, Harper, G P

“…Crystals of porcine synovial collagenase suitable for an X-ray structure analysis have been obtained. The crystals belong to space group I4, with unit cell…”
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Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides by WYATT, Paul G, COOMBER, Barry A, EVANS, Derek N, JACK, Torquil I, FULTON, Heather E, WONACOTT, Alan J, COLMAN, Peter, VARGHESE, Jose

“…SAR investigations of the 4- and 5-positions of a series of 4-amino-4H-pyran-2-carboxylic acid 6-carboxamides are reported. Potent inhibitors of influenza A…”
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Structural evidence for ligand-induced sequential conformational changes in glyceraldehyde 3-phosphate dehydrogenase by Leslie, A G, Wonacott, A J

“…Glyceraldehyde 3-phosphate dehydrogenase is a tetramer of four chemically identical subunits which requires the cofactor nicotinamide adenine dinucleotide…”
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Glyceraldehyde-3-Phosphate Dehydrogenase [and Discussion] by Dalziel, K., McFerran, N. V., Wonacott, A. J., Keleti, T.

“…Conflicting experimental evidence of the pathway of catalysis for the enzyme from rabbit, pig and lobster muscle tissues is reviewed. Transient kinetic studies…”
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Novel Natural Product 5,5-trans-Lactone Inhibitors of Human α-Thrombin:  Mechanism of Action and Structural Studies by Weir, Malcolm P, Bethell, Susanne S, Cleasby, Anne, Campbell, Callum J, Dennis, Richard J, Dix, Clive J, Finch, Harry, Jhoti, Harren, Mooney, Christopher J, Patel, Shila, Tang, Chi-Man, Ward, Malcolm, Wonacott, Alan J, Wharton, Christopher W

“…High-throughput screening of methanolic extracts from the leaves of the plant Lantana camara identified potent inhibitors of human α-thrombin, which were shown…”
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Sequence and structure of D -glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus by Biesecker, G, Ieuan Harris, J, Thierry, J. C, Walker, J. E, Wonacott, A. J

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Coenzyme binding in crystals of glyceraldehyde-3-phosphate dehydrogenase by Leslie, A G, Wonacott, A J

“…Apo-glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus and the partially saturated holo-enzyme can be crystallized isomorphously with…”
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Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus by Biesecker, G, Harris, J I, Thierry, J C, Walker, J E, Wonacott, A J

“…The glyceraldehyde 3-phosphate dehydogenase holoenzyme of Bacillus stearothermophilus possesses precise 222 symmetry: in this respect it differs from the…”
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Coenzyme binding and co-operativity in D-glyceraldehyde 3-phosphate dehydrogenase by Biesecker, G, Wonacott, A J

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Structure of Lactate Dehydrogenase at 2.8 Resolution by ADAMS, M. J, FORD, G. C, KOEKOEK, R, LENTZ, P. J, McPHERSON, A, ROSSMANN, M. G, SMILEY, I. E, SCHEVITZ, R. W, WONACOTT, A. J

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