Search Results - "Won Ha Lee"

Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders by Jha, Mithilesh Kumar, Lee, Won-Ha, Suk, Kyoungho

“…[Display omitted] Recent neuroscience research has established the adult brain as a dynamic organ having a unique ability to undergo changes with time…”
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Satellite glia as a critical component of diabetic neuropathy: Role of lipocalin‐2 and pyruvate dehydrogenase kinase‐2 axis in the dorsal root ganglion by Bhusal, Anup, Rahman, Md Habibur, Lee, Won‐Ha, Lee, In‐Kyu, Suk, Kyoungho

“…Diabetic peripheral neuropathy (DPN) is a common complication of uncontrolled diabetes. The pathogenesis of DPN is associated with chronic inflammation in…”
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Astrocyte‐derived lipocalin‐2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia by Kim, Jae‐Hong, Ko, Pan‐Woo, Lee, Ho‐Won, Jeong, Ji‐Young, Lee, Maan‐Gee, Kim, Jong‐Heon, Lee, Won‐Ha, Yu, Ri, Oh, Won‐Jong, Suk, Kyoungho

“…Lipocalin‐2 (LCN2) has diverse functions in multiple pathophysiological conditions; however, its pathogenic role in vascular dementia (VaD) is unknown. Here,…”
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Cathelicidin‐related antimicrobial peptide promotes neuroinflammation through astrocyte–microglia communication in experimental autoimmune encephalomyelitis by Bhusal, Anup, Nam, Youngpyo, Seo, Donggun, Rahman, Md Habibur, Hwang, Eun Mi, Kim, Seung‐Chan, Lee, Won‐Ha, Suk, Kyoungho

“…Cathelicidin‐related antimicrobial peptide (CRAMP) is an effector molecule of the innate immune system with direct antimicrobial and immunomodulatory…”
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Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases by Jha, Mithilesh Kumar, Kim, Jong-Heon, Song, Gyun Jee, Lee, Won-Ha, Lee, In-Kyu, Lee, Ho-Won, An, Seong Soo A, Kim, SangYun, Suk, Kyoungho

“…Astrocytes, which are homeostatic cells of the central nervous system (CNS), display remarkable heterogeneity in their morphology and function. Besides their…”
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Secreted protein lipocalin‐2 promotes microglial M1 polarization by Jang, Eunha, Lee, Shinrye, Kim, Jong‐Heon, Kim, Jae‐Hong, Seo, Jung‐Wan, Lee, Won‐Ha, Mori, Kiyoshi, Nakao, Kazuwa, Suk, Kyoungho

“…Activated macrophages are classified into two different forms: classically activated (M1) or alternatively activated (M2) macrophages. The presence of M1/M2…”
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Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration by Afridi, Ruqayya, Lee, Won-Ha, Suk, Kyoungho

“…Age-related chronic inflammatory activation of microglia and their dysfunction are observed in many neurodegenerative diseases, and the potential contributions…”
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Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications by Bhusal, Anup, Rahman, Md Habibur, Lee, Won-Ha, Bae, Yong Chul, Lee, In-Kyu, Suk, Kyoungho

“…[Display omitted] Lipocalin-2 (LCN2), also known as 24p3 and neutrophil gelatinase-associated lipocalin (NGAL), is a 25-kDa secreted protein implicated in…”
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Lipocalin-2 in Diabetic Complications of the Nervous System: Physiology, Pathology, and Beyond by Bhusal, Anup, Lee, Won-Ha, Suk, Kyoungho

“…Lipocalin-2 (LCN2) is a 25 kDa secreted protein that belongs to the family of lipocalins, a group of transporters of small hydrophobic molecules such as iron,…”
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Roles of lncRNAs in NF-κB-Mediated Macrophage Inflammation and Their Implications in the Pathogenesis of Human Diseases by Shin, Jae-Joon, Park, Jeongkwang, Shin, Hyeung-Seob, Arab, Imene, Suk, Kyoungho, Lee, Won-Ha

“…Over the past century, molecular biology's focus has transitioned from proteins to DNA, and now to RNA. Once considered merely a genetic information carrier,…”
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Bidirectional Communication Between Microglia and Astrocytes in Neuroinflammation by Bhusal, Anup, Afridi, Ruqayya, Lee, Won-Ha, Suk, Kyoungho

“…Neuroinflammation is a common feature of diverse nervous system pathologies. In many instances, it begins at an early stage of the disease, paving the way for…”
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Phenotypic polarization of activated astrocytes: the critical role of lipocalin-2 in the classical inflammatory activation of astrocytes by Jang, Eunha, Kim, Jong-Heon, Lee, Shinrye, Kim, Jae-Hong, Seo, Jung-Wan, Jin, Myungwon, Lee, Maan-Gee, Jang, Il-Sung, Lee, Won-Ha, Suk, Kyoungho

“…Astrocytes provide structural and functional support for neurons, as well as display neurotoxic or neuroprotective phenotypes depending upon the presence of an…”
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Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity and diabetes: Translational significance by Rahman, Md Habibur, Bhusal, Anup, Lee, Won-Ha, Lee, In-Kyu, Suk, Kyoungho

“…[Display omitted] Preclinical studies have suggested that chronic inflammation in the brain might be associated with multiple metabolic disorders, including…”
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LINC01686 affects LPS‐induced cytokine expression via the miR‐18a‐5p/A20/STAT1 axis in THP‐1 cells by Baek, Jongwon, Shin, Hyeung‐Seob, Suk, Kyoungho, Lee, Won‐Ha

“…Background and Objective Long noncoding RNAs (lncRNAs) are crucial in regulating various physiological and pathological processes, including immune responses…”
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Regulation by lipocalin-2 of neuronal cell death, migration, and morphology by Lee, Shinrye, Lee, Won-Ha, Lee, Myung-Shik, Mori, Kiyoshi, Suk, Kyoungho

“…A secreted protein, lipocalin‐2 (LCN2), has been previously shown to regulate a variety of cellular phenotypes such as cell death, migration, and morphology…”
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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation by Bhusal, Anup, Lee, Won-Ha, Suk, Kyoungho

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The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes by Bhusal, Anup, Kim, Jae-Hong, Kim, Seung-Chan, Hwang, Eun Mi, Ryu, Hoon, Ali, Md. Sekendar, Park, Seung-Chun, Lee, Won-Ha, Suk, Kyoungho

“…Peptidoglycan recognition protein 1 (PGLYRP1) is a pattern-recognition protein that mediates antibacterial actions and innate immune responses. Its expression…”
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Mitochondrial dysfunction regulates the JAK-STAT pathway via LKB1-mediated AMPK activation ER-stress-independent manner by Kim, Dong-Yeon, Lim, Su-Geun, Suk, Kyoungho, Lee, Won-Ha

“…Mitochondria affect cellular functions alone or in cooperation with other cellular organelles. Recent research has demonstrated the close relationship of…”
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Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis by Lee, Shinrye, Park, Jae-Yong, Lee, Won-Ha, Kim, Ho, Park, Hae-Chul, Mori, Kiyoshi, Suk, Kyoungho

“…Astrocytes, the most abundant glial cell type in the brain, provide metabolic and trophic support to neurons and modulate synaptic activity. In response to a…”
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Cathelicidin-Related Antimicrobial Peptide Negatively Regulates Bacterial Endotoxin-Induced Glial Activation by Bhusal, Anup, Nam, Youngpyo, Seo, Donggun, Lee, Won-Ha, Suk, Kyoungho

“…Recent studies have suggested that mouse cathelicidin-related antimicrobial peptide (CRAMP) and its human homologue leucine leucine-37 (LL-37) play critical…”
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