Search Results - "Won, Haejung"

TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients by Hossain, Dewan M S, Pal, Sumanta K, Moreira, Dayson, Duttagupta, Priyanka, Zhang, Qifang, Won, Haejung, Jones, Jeremy, D'Apuzzo, Massimo, Forman, Stephen, Kortylewski, Marcin

“…Recent advances in immunotherapy of advanced human cancers underscored the need to address and eliminate tumor immune evasion. The myeloid-derived suppressor…”
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TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs by Won, Haejung, Moreira, Dayson, Gao, Chan, Duttagupta, Priyanka, Zhao, Xingli, Manuel, Edwin, Diamond, Don, Yuan, Yate‐Ching, Liu, Zheng, Jones, Jeremy, D’Apuzzo, Massimo, Pal, Sumanta, Kortylewski, Marcin

“…TLR9 upregulation in prostate cancer cells results in the LIF‐mediated recruitment and increased tolerogenic activity of polymorphonuclear myeloid‐derived…”
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Reduced T-cell Numbers and Elevated Levels of Immunomodulatory Cytokines in Metastatic Prostate Cancer Patients De Novo Resistant to Abiraterone and/or Enzalutamide Therapy by Pal, Sumanta K, Moreira, Dayson, Won, Haejung, White, Seok Woon, Duttagupta, Pryanka, Lucia, Marc, Jones, Jeremy, Hsu, JoAnn, Kortylewski, Marcin

“…Currently, there are two Food and Drug Administration (FDA)-approved drugs for androgen deprivation therapy (ADT) of metastatic castration-resistant prostate…”
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Myeloid cell-targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell-mediated immunity by Moreira, Dayson, Sampath, Sagus, Won, Haejung, White, Seok Voon, Su, Yu-Lin, Alcantara, Marice, Wang, Chongkai, Lee, Peter, Maghami, Ellie, Massarelli, Erminia, Kortylewski, Marcin

“…The tumor microenvironment affects the outcome of radiotherapy against head and neck squamous cell carcinoma (HNSCC). We recently found that tolerogenic…”
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Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia by Zhang, Qifang, Hossain, Dewan Md Sakib, Duttagupta, Priyanka, Moreira, Dayson, Zhao, Xingli, Won, Haejung, Buettner, Ralf, Nechaev, Sergey, Majka, Marcin, Zhang, Bin, Cai, Qi, Swiderski, Piotr, Kuo, Ya-Huei, Forman, Stephen, Marcucci, Guido, Kortylewski, Marcin

“…Targeting oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) in acute myeloid leukemia (AML) can reduce blast survival…”
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Abstract 35: Chemo-radiotherapy induces tolerogenic STAT3 signaling in circulating myeloid-derived suppressor cells in patients with head and neck squamous cell carcinoma (HNSCC) by Won, Haejung, Sampath, Sagus, Massarelli, Erminia, Maghami, Ellie, Kortylewski, Marcin

“…Abstract Background and Objectives: While radiation therapy (RT) and certain types of chemotherapy are potentially immunogenic, they rarely generate antitumor…”
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Effect of IL-6 and related mediators on resistance to abiraterone acetate (abi) and enzalutamide (enza) in patients with metastatic castration-resistant prostate cancer (mCRPC) by Adashek, Jacob J., Won, Haejung, Moreira, Dayson, Duttagupta, Priyanka, Twardowski, Przemyslaw, Jones, Jeremy, Kortylewski, Marcin, Pal, Sumanta K.

“…Abstract only 296 Background: IL-6 is an upstream regulator of various moieties, including STAT3, that are associated with a poor prognosis in mCRPC. The…”
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Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1 by Won, Haejung, Nandakumar, Vijayalakshmi, Yates, Peter, Sanchez, Suzi, Jones, Lindsey, Huang, Xue F., Chen, Si-Yi

“…The mechanisms controlling the development of dendritic cells (DCs) remain incompletely understood. Using an Mysm1 knockout (Mysm1−/−) mouse model, we…”
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Combined modality radiation therapy promotes tolerogenic myeloid cell populations and STAT3-related gene expression in head and neck cancer patients by Sampath, Sagus, Won, Haejung, Massarelli, Erminia, Li, Min, Frankel, Paul, Vora, Nayana, Vora, Lalit, Maghami, Ellie, Kortylewski, Marcin

“…Immunomodulation contributes to the antitumor efficacy of the fractionated radiation therapy (RT). Here, we describe immune effects of RT with concurrent…”
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B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors by Zhao, Xingli, Zhang, Zhuoran, Moreira, Dayson, Su, Yu-Lin, Won, Haejung, Adamus, Tomasz, Dong, Zhenyuan, Liang, Yong, Yin, Hongwei H., Swiderski, Piotr, Pillai, Raju K., Kwak, Larry, Forman, Stephen, Kortylewski, Marcin

“…Growing evidence links the aggressiveness of non-Hodgkin’s lymphoma, especially the activated B cell-like type diffuse large B cell lymphomas (ABC-DLBCLs) to…”
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Association of microbiome and plasma cytokine dynamics to nivolumab response in metastatic renal cell carcinoma (mRCC) by Maia, Manuel C., Poroyko, Valeriy, Won, Haejung, Almeida, Lorena, Bergerot, Paulo Gustavo, Dizman, Nazli, Hsu, Joann, Jones, Jeremy, Salgia, Ravi, Pal, Sumanta K.

“…Abstract only 656 Background: Checkpoint inhibitors (CPI) represent a standard of care in mRCC. The relationship of the microbiome to benefit from CPIs has…”
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261. Gain-of-Function Effect Augments Therapeutic Efficacy of CpG-STAT3 Anti-Sense Oligonucleotide Against Castration-Resistant Prostate Cancers by Moreira, Dayson, Zhao, Xingli, Won, Haejung, Duttagupta, Priyanka, Pal, Summanta, Kortylewski, Marcin

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Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1 by Jiang, Xiao-Xia, Nguyen, Quan, Chou, YuChia, Wang, Tao, Nandakumar, Vijayalakshmi, Yates, Peter, Jones, Lindsey, Wang, Lifeng, Won, Haejung, Lee, Hye-Ra, Jung, Jae U., Müschen, Markus, Huang, Xue F., Chen, Si-Yi

“…Epigenetic histone modifications play critical roles in the control of gene transcription. Recently, an increasing number of histone H2A deubiquitinases have…”
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Gut microbiome composition and response to sunitinib in metastatic renal cell carcinoma (mRCC) by Gong, Jun, Dizman, Nazli, Poroyko, Valeriy, Won, Haejung, Bergerot, Cristiane Decat, Bergerot, Paulo Gustavo, Maia, Manuel C., Hsu, Joann, Frankel, Paul Henry, Jones, Jeremy, Salgia, Ravi, Pal, Sumanta K.

“…Abstract only 657 Background: Recent evidence supports a link between stool microbiome composition and immunotherapy response. However, it is unclear how the…”
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Histone H2A deubiquitinase MYSM1 is essential for dendritic cell development (P4488) by Won, Haejung, Chou, Yuchia, Wang, Tao, Jones, Lindsey, Huang, Xue, Chen, Si-Yi

“…Abstract The mechanisms controlling differentiation of dendritic cells remain largely unknown. Using knockout mouse model, we identified Mysm1 as a critical…”
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