Search Results - "Womack, M D"

Large conductance calcium-activated potassium channels affect both spontaneous firing and intracellular calcium concentration in cerebellar Purkinje neurons by Womack, M.D, Hoang, C, Khodakhah, K

“…Abstract We investigated the contribution of large conductance calcium-activated potassium (BK) channels to spontaneous activity of cerebellar Purkinje neurons…”
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Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties by Schechter, L E, Smith, D L, Rosenzweig-Lipson, S, Sukoff, S J, Dawson, L A, Marquis, K, Jones, D, Piesla, M, Andree, T, Nawoschik, S, Harder, J A, Womack, M D, Buccafusco, J, Terry, A V, Hoebel, B, Rada, P, Kelly, M, Abou-Gharbia, M, Barrett, J E, Childers, W

“…Recent data has suggested that the 5-hydroxytryptamine (5-HT)(1A) receptor is involved in cognitive processing. A novel 5-HT(1A) receptor antagonist,…”
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Quantitative analysis of voltage-gated potassium currents from primary equine (Equus caballus) and elephant (Loxodonta africana) articular chondrocytes by Mobasheri, A, Gent, T C, Womack, M D, Carter, S D, Clegg, P D, Barrett-Jolley, R

“…In this comparative study, we have established in vitro models of equine and elephant articular chondrocytes, examined their basic morphology, and…”
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Inhibition by α‐Tetrahydrodeoxycorticosterone (THDOC) of Pre‐Sympathetic Parvocellular Neurones in the Paraventricular Nucleus of Rat Hypothalamus by Womack, M D, Pyner, S, Barrett‐Jolley, R

“…Background and Purpose: α‐tetrahydrodeoxycorticosterone (THDOC) is an endogenous neuroactive steroid which increases in plasma and brain concentration during…”
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Pharmacological characterization of the 5‐HT receptor‐mediated contraction in the mouse isolated ileum by Tuladhar, B R, Womack, M D, Naylor, R J

“…The pharmacological characterization of a 5‐HT receptor‐mediated contractile response in the mouse isolated ileum is described. In the presence of methysergide…”
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Interaction of opioids and membrane potential to modulate Ca2+ channels in rat dorsal root ganglion neurons by Womack, M D, McCleskey, E W

“…1. Using patch-clamp methods, we show that brief prepulses to very positive voltages increase (facilitate) the amplitude of current through Ca2+ channels…”
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Substance P elevates intracellular calcium in both neurons and glial cells from the dorsal horn of the spinal cord by Heath, M J, Womack, M D, MacDermott, A B

“…1. We used microfluorimetric measurement of [Ca2+]i to identify substance P-sensitive cells acutely isolated from the dorsal horn of neonatal rats. We then…”
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Sensory transmitters regulate intracellular calcium in dorsal horn neurons by Womack, M. D, MacDermott, A. B, Jessell, T. M

“…Primary afferent terminals in the dorsal horn of the spinal cord release excitatory amino acid and peptide transmitters that initiate the central processing of…”
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Evidence for functional ATP-sensitive (KATP ) potassium channels in human and equine articular chondrocytes by Mobasheri, A., B.Sc., A.R.C.S. (Hons.), M.Sc., D.Phil. (Oxon.), Gent, T.C., B.Sc. (Hons.), Nash, A.I., B.Sc. (Hons.), Womack, M.D., B.Sc. (Hons.), Ph.D. (Hons.), Moskaluk, C.A., M.D., Ph.D, Barrett-Jolley, R., B.Sc. (Hons.), D.Phil. (Oxon.)

“…Summary Objective Chondrocytes are highly sensitive to variations in extracellular glucose and oxygen levels in the extracellular matrix. As such, they must…”
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Functional substance P receptors on a rat pancreatic acinar cell line by Womack, MD, Hanley, MR, Jessell, TM

“…A pancreatic acinar cell line, AR4-2J, that expresses a high density of substance P (SP)-binding sites has been identified. SP-binding sites on intact AR4-2J…”
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Inhibition by [alpha]-Tetrahydrodeoxycorticosterone (THDOC) of Pre-Sympathetic Parvocellular Neurones in the Paraventricular Nucleus of Rat Hypothalamus by Womack, M D, Pyner, S, Barrett-Jolley, R

“…BACKGROUND AND PURPOSE: alpha-tetrahydrodeoxycorticosterone (THDOC) is an endogenous neuroactive steroid which increases in plasma and brain concentration…”
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Fast, local signal transduction between the mu opioid receptor and Ca2+ channels by Wilding, TJ, Womack, MD, McCleskey, EW

“…We used patch-clamp methods to describe signal transduction between the mu opioid receptor, the binding site for morphine, and high-threshold Ca2+ channels in…”
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Detergent effects on enzyme activity and solubilization of lipid bilayer membranes by Womack, M D, Kendall, D A, MacDonald, R C

“…Over 50 detergents were tested to establish which would be most effective in releasing proteins from membrane-bounded compartments without denaturing them…”
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Impaired calcium release in cerebellar Purkinje neurons maintained in culture by Womack, M D, Walker, J W, Khodakhah, K

“…Cerebellar Purkinje neurons demonstrate a form of synaptic plasticity that, in acutely prepared brain slices, has been shown to require calcium release from…”
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Structural properties of voltage-dependent calcium channels by McCleskey, E W, Womack, M D, Fieber, L A

“…Following purification using Ca2+ channel drugs as ligands, the skeletal muscle Ca2+ channel was shown to be a five-subunit structure containing one large (175…”
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Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia by Khodakhah, Kamran, Walter, Joy T, Alviña, Karina, Womack, Mary D, Chevez, Carolyn

“…Episodic ataxia type-2 (EA2) is caused by mutations in P/Q-type voltage-gated calcium channels that are expressed at high densities in cerebellar Purkinje…”
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Sensory transmitters regulate intracellular calcium in dorsal horn neurons by Womack, M. D, MacDermott, A. B, Jessell, T. M

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Calcium-Activated Potassium Channels Are Selectively Coupled to P/Q-Type Calcium Channels in Cerebellar Purkinje Neurons by Womack, Mary D, Chevez, Carolyn, Khodakhah, Kamran

“…Cerebellar Purkinje neurons fire spontaneously in the absence of synaptic transmission. P/Q-type voltage-gated calcium channels and calcium-activated potassium…”
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Somatic and Dendritic Small-Conductance Calcium-Activated Potassium Channels Regulate the Output of Cerebellar Purkinje Neurons by Womack, Mary D, Khodakhah, Kamran

“…Cerebellar Purkinje neurons provide the sole output of the cerebellar cortex and play a crucial role in motor coordination and maintenance of balance. They are…”
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Dendritic Control of Spontaneous Bursting in Cerebellar Purkinje Cells by Womack, Mary D, Khodakhah, Kamran

“…We investigated the mechanisms that contribute to spontaneous regular bursting in adult Purkinje neurons in acutely prepared cerebellar slices. Bursts…”
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