Ex vivo gene therapy of two children with X-linked severe combined immunodeficiency

Bone marrow transplantation (BMT) for XSCID is not fully satisfactory because most patients lack an HLA-matched relative and receive HLA-haploidentical BMTs, which may not provide lasting immune reconstitution.

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 115; no. 2; p. S202
Main Authors:	Chinen, J., Davis, J., Linton, G.F., Theobald-Whitting, N.L., Woltz, P.C., Buckley, R.H., Malech, H.L., Puck, J.M.
Format:	Journal Article
Language:	English
Published:	St. Louis Mosby, Inc 01-02-2005 Elsevier Limited
Subjects:	Bone marrow Gene therapy Immune system Patients Transplants & implants
Online Access:	Get full text
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Description
Summary:	Bone marrow transplantation (BMT) for XSCID is not fully satisfactory because most patients lack an HLA-matched relative and receive HLA-haploidentical BMTs, which may not provide lasting immune reconstitution.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2004.12.819