Search Results - "Wolton, Kathryn"

Dictyostelium discoideum: An Alternative Nonanimal Model for Developmental Toxicity Testing by Baines, Robert P, Wolton, Kathryn, Thompson, Christopher R L

“…Abstract A critical aspect of toxicity evaluation is developmental and reproductive toxicity (DART) testing. Traditionally, DART testing has been conducted in…”
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A mathematical model of the role of aggregation in sonic hedgehog signalling by Derrick, Daniel J A, Wolton, Kathryn, Currie, Richard A, Tindall, Marcus John

“…Effective regulation of the sonic hedgehog (Shh) signalling pathway is essential for normal development in a wide variety of species. Correct Shh signalling…”
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Erbb2 is required for cardiac atrial electrical activity during development by Tenin, Gennadiy, Clowes, Christopher, Wolton, Kathryn, Krejci, Eliska, Wright, Jayne A, Lovell, Simon C, Sedmera, David, Hentges, Kathryn E

“…The heart is the first organ required to function during embryonic development and is absolutely necessary for embryo survival. Cardiac activity is dependent…”
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Applying discovery toxicology approaches for prediction of developmental phenotypes – a case study by Wolton, Kathryn, Barnes, Emma, Currie, Richard

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Next generation risk assessment for occupational chemical safety – A real world example with sodium-2-hydroxyethane sulfonate by Wood, Adam, Breffa, Catherine, Chaine, Caroline, Cubberley, Richard, Dent, Matthew, Eichhorn, Joachim, Fayyaz, Susann, Grimm, Fabian A., Houghton, Jade, Kiwamoto, Reiko, Kukic, Predrag, Lee, MoungSook, Malcomber, Sophie, Martin, Suzanne, Nicol, Beate, Reynolds, Joe, Riley, Gordon, Scott, Sharon, Smith, Colin, Westmoreland, Carl, Wieland, Willemien, Williams, Mesha, Wolton, Kathryn, Zellmann, Tristan, Gutsell, Steve

“…Next Generation Risk Assessment (NGRA) is an exposure-led approach to safety assessment that uses New Approach Methodologies (NAMs). Application of NGRA has…”
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Zfp521 promotes B-cell viability and cyclin D1 gene expression in a B cell culture system by Al Dallal, Salma, Wolton, Kathryn, Hentges, Kathryn E

“…Highlights • Knockdown of Zfp521 in BCL1 cell culture reduces viability and promotes apoptosis. • Genes expressed in B cells are down-regulated in cells with…”
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Two alleles of Med31 provide a model to study delayed fetal growth and endochondral ossification by Wolton, Kathryn, Barnes, Emma, Wright, Jayne, Hentges, Kathryn

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Two Alleles of Med31 Provide a Model to Study Delayed Fetal Growth, Proliferation and Placental Development by Wolton, Kathryn

“…Fetal growth restriction (FGR) is the failure of a fetus to reach its pre-determined genetic growth potential during development. FGR is associated both with…”
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