Search Results - "Wolthuis, Rob M.F"

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension by Medema, René H, Lens, Susanne M.A, Wolthuis, Rob M.F, Klompmaker, Rob, Kauw, Jos, Agami, Reuven, Brummelkamp, Thijn, Kops, Geert

“…Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive. We show that mammalian…”
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APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit by van Zon, Wouter, Ogink, Janneke, ter Riet, Bas, Medema, René H, te Riele, Hein, Wolthuis, Rob M.F

“…The ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) is activated at prometaphase by mitotic phosphorylation and binding of its activator, Cdc20…”
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Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint by van Zon, Wouter, Wolthuis, Rob M F

“…Active cyclin B1-Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the chromosomes and for incorrect…”
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Point-of-care CRISPR/Cas nucleic acid detection: Recent advances, challenges and opportunities by van Dongen, Jeanne E., Berendsen, Johanna T.W., Steenbergen, Renske D.M., Wolthuis, Rob M.F., Eijkel, Jan C.T., Segerink, Loes I.

“…With the trend of moving molecular tests from clinical laboratories to on-site testing, there is a need for nucleic acid based diagnostic tools combining the…”
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WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion by Benedict, Bente, van Schie, Janne J.M., Oostra, Anneke B., Balk, Jesper A., Wolthuis, Rob M.F., Riele, Hein te, de Lange, Job

“…Premature loss of sister chromatid cohesion at metaphase is a diagnostic marker for different cohesinopathies. Here, we report that metaphase spreads of many…”
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Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression by Lindqvist, Arne, van Zon, Wouter, Karlsson Rosenthal, Christina, Wolthuis, Rob M F

“…Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic…”
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Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of Aurora B by van Leuken, Renske J., Luna-Vargas, Mark P., Sixma, Titia K., Wolthuis, Rob M.F., Medema, René H.

“…Accurate chromosome segregation relies on the mitotic spindle checkpoint. This checkpoint acts to restrict ubiquitin ligase activity of the Anaphase-promoting…”
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MASTL is the human ortholog of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis by Voets, Erik, Wolthuis, Rob M.F.

“…Greatwall (Gwl) was originally discovered in Drosophila as an essential kinase for correct chromosome condensation and mitotic progression. In Xenopus, Gwl may…”
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Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis by van Vugt, Marcel A T M, van de Weerdt, Barbara C M, Vader, Gerben, Janssen, Hans, Calafat, Jero, Klompmaker, Rob, Wolthuis, Rob M F, Medema, René H

“…Polo-like kinase-1 (Plk1) performs multiple essential functions during the cell cycle. Here we show that human Plk1-deficient cells are unable to separate…”
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Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F by Gurden, Mark D.J, Holland, Andrew J, van Zon, Wouter, Tighe, Anthony, Vergnolle, Mailys A, Andres, Douglas A, Spielmann, H. Peter, Malumbres, Marcos, Wolthuis, Rob M.F, Cleveland, Don W, Taylor, Stephen S

“…Progression through mitosis and cytokinesis requires the sequential proteolysis of several cell-cycle regulators. This proteolysis is mediated by the…”
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The Small GTPase, Rap1, Mediates CD31-Induced Integrin Adhesion by Reedquist, Kris A., Ross, Ewan, Koop, Elianne A., Rob M. F. Wolthuis, Fried J. T. Zwartkruis, van Kooyk, Yvette, Salmon, Mike, Buckley, Christopher D., Bos, Johannes L.

“…Integrin-mediated leukocyte adhesion is a critical aspect of leukocyte function that is tightly regulated by diverse stimuli, including chemokines, antigen…”
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Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling by Zwartkruis, Fried J.T., Wolthuis, Rob M.F., Nabben, Nicolle M.J.M., Franke, Barbara, Bos, Johannes L.

“…The small GTPase Rap1 has been implicated in both negative and positive control of Ras‐mediated signalling events. We have investigated which extracellular…”
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Keeping ribosomal DNA intact: a repeating challenge by Warmerdam, Daniël O., Wolthuis, Rob M. F.

“…More than half of the human genome consists of repetitive sequences, with the ribosomal DNA (rDNA) representing two of the largest repeats. Repetitive rDNA…”
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MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis by Voets, Erik, Wolthuis, Rob M F

“…Greatwall (Gwl) was originally discovered in Drosophila as an essential kinase for correct chromosome condensation and mitotic progression. In Xenopus, Gwl may…”
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RalGEF2, a Pleckstrin Homology Domain Containing Guanine Nucleotide Exchange Factor for Ral by de Bruyn, Kim M.T., de Rooij, Johan, Wolthuis, Rob M.F., Rehmann, Holger, Wesenbeek, Joep, Cool, Robbert H., Wittinghofer, Alfred H., Bos, Johannes L.

“…Ral is a ubiquitously expressed Ras-like small GTPase. Several guanine nucleotide exchange factors for Ral have been identified, including members of the…”
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Differential fMet-Leu-Phe- and Platelet-activating Factor-induced Signaling Toward Ral Activation in Primary Human Neutrophils by M'Rabet, Laura, Coffer, Paul J., Wolthuis, Rob M.F., Zwartkruis, Fried, Koenderman, Leo, Bos, Johannes L.

“…We have measured the activation of the small GTPase Ral in human neutrophils after stimulation with fMet-Leu-Phe (fMLP), platelet activating factor (PAF), and…”
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ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation by van der Weegen, Yana, de Lint, Klaas, van den Heuvel, Diana, Nakazawa, Yuka, Mevissen, Tycho E. T., van Schie, Janne J. M., San Martin Alonso, Marta, Boer, Daphne E. C., González-Prieto, Román, Narayanan, Ishwarya V., Klaassen, Noud H. M., Wondergem, Annelotte P., Roohollahi, Khashayar, Dorsman, Josephine C., Hara, Yuichiro, Vertegaal, Alfred C. O., de Lange, Job, Walter, Johannes C., Noordermeer, Sylvie M., Ljungman, Mats, Ogi, Tomoo, Wolthuis, Rob M. F., Luijsterburg, Martijn S.

“…Cells employ transcription-coupled repair (TCR) to eliminate transcription-blocking DNA lesions. DNA damage-induced binding of the TCR-specific repair factor…”
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PRDM10 directs FLCN expression in a novel disorder overlapping with Birt–Hogg–Dubé syndrome and familial lipomatosis by van de Beek, Irma, Glykofridis, Iris E, Oosterwijk, Jan C, van den Akker, Peter C, Diercks, Gilles F H, Bolling, Maria C, Waisfisz, Quinten, Mensenkamp, Arjen R, Balk, Jesper A, Zwart, Rob, Postma, Alex V, Meijers-Heijboer, Hanne E J, van Moorselaar, R Jeroen A, Wolthuis, Rob M F, Houweling, Arjan C

“…Abstract Birt–Hogg–Dubé syndrome (BHD) is an autosomal dominant disorder characterized by fibrofolliculomas, pulmonary cysts, pneumothoraces and renal cell…”
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Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion by van Schie, Janne J. M., Faramarz, Atiq, Balk, Jesper A., Stewart, Grant S., Cantelli, Erika, Oostra, Anneke B., Rooimans, Martin A., Parish, Joanna L., de Almeida Estéves, Cynthia, Dumic, Katja, Barisic, Ingeborg, Diderich, Karin E. M., van Slegtenhorst, Marjon A., Mahtab, Mohammad, Pisani, Francesca M., te Riele, Hein, Ameziane, Najim, Wolthuis, Rob M. F., de Lange, Job

“…Warsaw Breakage Syndrome (WABS) is a rare disorder related to cohesinopathies and Fanconi anemia, caused by bi-allelic mutations in DDX11 . Here, we report…”
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ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients by Apelt, Katja, White, Susan M, Kim, Hyun Suk, Yeo, Jung-Eun, Kragten, Angela, Wondergem, Annelotte P, Rooimans, Martin A, González-Prieto, Román, Wiegant, Wouter W, Lunke, Sebastian, Flanagan, Daniel, Pantaleo, Sarah, Quinlan, Catherine, Hardikar, Winita, van Attikum, Haico, Vertegaal, Alfred C O, Wilson, Brian T, Wolthuis, Rob M F, Schärer, Orlando D, Luijsterburg, Martijn S

“…ERCC1-XPF is a multifunctional endonuclease involved in nucleotide excision repair (NER), interstrand cross-link (ICL) repair, and DNA double-strand break…”
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